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MOB3C MOB kinase activator 3C [ Homo sapiens (human) ]

Gene ID: 148932, updated on 5-Mar-2024

Summary

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Official Symbol
MOB3Cprovided by HGNC
Official Full Name
MOB kinase activator 3Cprovided by HGNC
Primary source
HGNC:HGNC:29800
See related
Ensembl:ENSG00000142961 AllianceGenome:HGNC:29800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOB1E; MOBKL2C
Summary
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 4.4), spleen (RPKM 4.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46607719..46616811, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46484946..46494037, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47073391..47082483, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MKNK1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47013004-47013504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47013505-47014005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47015442-47016081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47021539-47022040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47022041-47022540 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47024335-47024504 Neighboring gene kinocilin Neighboring gene MAPK interacting serine/threonine kinase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:47069254-47069754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47078933-47079556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 849 Neighboring gene uncharacterized LOC105378697 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47131482-47132011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47132012-47132540 Neighboring gene neudesin neurotrophic factor pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular characterization of human homologs of yeast MOB1. Chow A, et al. Int J Cancer, 2010 May 1. PMID 19739119
  2. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, et al. Cell Rep, 2017 Jul 11. PMID 28700943, Free PMC Article
  3. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira FR, et al. Biochem J, 2016 Oct 15. PMID 27503909, Free PMC Article
  4. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26743

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MOB kinase activator 3C
Names
MOB1, Mps One Binder kinase activator-like 2C
mob1 homolog 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027514.1 RefSeqGene

    Range
    5081..14173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_145279.5 → NP_660322.3  MOB kinase activator 3C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL136373
    Consensus CDS
    CCDS540.1
    UniProtKB/Swiss-Prot
    D3DQ22, Q0VA98, Q5TC10, Q5TC11, Q70IA8, Q8NAZ2, Q8NF28
    UniProtKB/TrEMBL
    X6R3L3
    Related
    ENSP00000271139.9, ENST00000271139.13
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

  2. NM_201403.3 → NP_958805.1  MOB kinase activator 3C

    See identical proteins and their annotated locations for NP_958805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' UTR exon, compared to variant 1, that results in the use of a downstream start codon. The encoded isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL136373
    Consensus CDS
    CCDS540.1
    UniProtKB/Swiss-Prot
    D3DQ22, Q0VA98, Q5TC10, Q5TC11, Q70IA8, Q8NAZ2, Q8NF28
    UniProtKB/TrEMBL
    X6R3L3
    Related
    ENSP00000315113.3, ENST00000319928.9
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46607719..46616811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46484946..46494037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q70IA8.1 GenPept UniProtKB/Swiss-Prot:Q70IA8

Gene LinkOut

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