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Gsto1 glutathione S-transferase omega 1 [ Mus musculus (house mouse) ]

Gene ID: 14873, updated on 21-Apr-2024

Summary

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Official Symbol
Gsto1provided by MGI
Official Full Name
glutathione S-transferase omega 1provided by MGI
Primary source
MGI:MGI:1342273
See related
Ensembl:ENSMUSG00000025068 AllianceGenome:MGI:1342273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p28; Gstx; Spg-r; Gsto-1
Summary
This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015]
Expression
Broad expression in stomach adult (RPKM 297.2), bladder adult (RPKM 158.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D1; 19 40.41 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47843412..47853229)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47854973..47864790)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene microRNA 8090 Neighboring gene STARR-seq mESC enhancer starr_46371 Neighboring gene STARR-positive B cell enhancer ABC_E2529 Neighboring gene STARR-seq mESC enhancer starr_46373 Neighboring gene STARR-seq mESC enhancer starr_46374 Neighboring gene STARR-positive B cell enhancer ABC_E1529 Neighboring gene predicted gene, 30021 Neighboring gene STARR-positive B cell enhancer ABC_E1530 Neighboring gene glutathione S-transferase omega 2 Neighboring gene STARR-positive B cell enhancer ABC_E7670 Neighboring gene VISTA enhancer mm324 Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47993319-47993502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation. Tummala P, et al. Carcinogenesis, 2021 Jun 21. PMID 33564842
  2. Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina. Fernando N, et al. Invest Ophthalmol Vis Sci, 2018 Sep 4. PMID 30193308
  3. GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity. Menon D, et al. Sci Rep, 2017 Dec 19. PMID 29259211, Free PMC Article
  4. Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages. Menon D, et al. Free Radic Biol Med, 2014 Aug. PMID 24873723
  5. Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: enzyme and arsenic species concentrations in tissues after arsenate administration. Chowdhury UK, et al. Toxicol Appl Pharmacol, 2006 Nov 1. PMID 16930657

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of glutathione S-transferase omega 1-catalyzed protein deglutathionylation suppresses adipocyte differentiation.
    Title: Inhibition of glutathione S-transferase omega 1-catalyzed protein deglutathionylation suppresses adipocyte differentiation.
  2. Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
    Title: Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
  3. ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation.
    Title: ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation.
  4. Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
    Title: Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation.
  5. GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1alpha-induced eosinophilic airway inflammation.
    Title: GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1α-induced eosinophilic airway inflammation.
  6. The potential therapeutic utility of GSTO1-1 inhibitors in the modulation of inflammation.
    Title: GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.
  7. These results indicate that GSTO1-1 is required for inflammatory-mediated photoreceptor death in retinal degenerations. Targeting GSTO1-1 may be a useful strategy to reduce oxidative stress and inflammation and ameliorate photoreceptor loss, slowing the progression of retinal degenerations.
    Title: Photoreceptor Survival Is Regulated by GSTO1-1 in the Degenerating Retina.
  8. Data indicate that GSTO1-1 is required for LPS-mediated signalling in macrophages and that it acts early in the LPS-TLR4 pro-inflammatory pathway.
    Title: GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway.
  9. shRNA knockdown of GSTO1-1 in macrophage-like J774.1A cells blocks the expression of NADPH oxidase 1 and the generation of reactive oxygen species after Bacterial lipopolysaccharide stimulation.
    Title: Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.
  10. Genes encoding the antioxidants GPX2 and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
    Title: Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione dehydrogenase (ascorbate) activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methylarsonate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-ascorbic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ascorbic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-ascorbic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase omega-1
Names
Glutathione transferase omega 1 (GSTO 1-1) (p28)
MMA(V) reductase
S-(Phenacyl)glutathione reductase
glutathione S-transferase omega 1-1
glutathione-S-transferase like
glutathione-dependent dehydroascorbate reductase
monomethylarsonic acid reductase
NP_034492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010362.3 → NP_034492.1  glutathione S-transferase omega-1

    See identical proteins and their annotated locations for NP_034492.1

    Status: REVIEWED

    Source sequence(s)
    AC126679, AI846704, AK146834, BE860946
    Consensus CDS
    CCDS29893.1
    UniProtKB/Swiss-Prot
    O09131, Q3TH87
    Related
    ENSMUSP00000026050.8, ENSMUST00000026050.8
    Conserved Domains (3) summary
    cd03184
    Location:108 → 228
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    COG0625
    Location:26 → 224
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03055
    Location:5 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47843412..47853229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09131.2 GenPept UniProtKB/Swiss-Prot:O09131

Gene LinkOut

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