Gstp2 glutathione S-transferase, pi 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstp2provided by MGI
Official Full Name: glutathione S-transferase, pi 2provided by MGI
Primary source: MGI:MGI:95864
See related: Ensembl:ENSMUSG00000038155 AllianceGenome:MGI:95864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gst3; Gst-3; GSTpiA
Summary: Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Predicted to be located in mitochondrion; nucleus; and plasma membrane. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cranium; eye; heart; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 669.0), stomach adult (RPKM 478.7) and 27 other tissues See more
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Genomic context

Location:: 19 A; 19 3.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4090288..4092221, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4040288..4042221, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
Title: Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.
Title: Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration.
Matrin 3 interacts specifically with the heat shock proteins glucose-regulated protein 78, GRP75 and glutathione S-transferase pi isoform 2.
Title: Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase π isoform 2 (GSTπ2) in thymoma cells.
Apc(Min/+)Gstp1/p2(-/-) (Gstp-null Apc(Min)) mice had a 6-fold increase in colon adenoma incidence, and a 50-fold increase in colorectal adenoma multiplicity, relative to Gstp-wt Apc(Min).
Title: Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.
GSTP protects against the endothelial dysfunction induced by tobacco smoke exposure and that this protection may be related to the detoxification of acrolein or other related cigarette smoke constituents.
Title: Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke.
The downregulation of Gstp2 may induce an increase of oxidative damage in the pyramidal cells of the CA1 and CA3 regions and granular layer of the dentate gyrus, leading to structural and functional damage.
Title: Chronic restraint stress decreases the expression of glutathione S-transferase pi2 in the mouse hippocampus.
The glutathione S-transferase, pi 2 was represented by two EST clones with similar levels of downregulation.
Title: Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.
critical role of allyl groups and disulfide chain in induction by diallyl disulfide, a naturally occurring chemopreventive agent in garlic
Title: Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic.
These results suggest that GSTpi may play a protective role in the development of spontaneous tumors.
Title: Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice.
role as a direct inhibitor of JNK in vivo and in regulating the constitutive expression of specific downstream molecular targets of the JNK signaling pathway
Title: Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S-nitrosoglutathione binding	ISO Inferred from Sequence Orthology more info
enables dinitrosyl-iron complex binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione derivative biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TRAF2-GSTP1 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase P 2

Names: GST YF-YF; GST class-pi; GST-piA; Gst p-2; gst P2

NP_861461.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181796.2 → NP_861461.1 glutathione S-transferase P 2

See identical proteins and their annotated locations for NP_861461.1

Status: PROVISIONAL

Source sequence(s)

BC064781

Consensus CDS

CCDS29412.1

UniProtKB/Swiss-Prot

P46425, Q505C3

UniProtKB/TrEMBL

A0A494BAW2

Related

ENSMUSP00000038931.10, ENSMUST00000042700.12

Conserved Domains (3) summary

PTZ00057
Location:6 → 196

PTZ00057; glutathione s-transferase; Provisional

cd03210
Location:84 → 210

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

cd03076
Location:3 → 76

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...