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SLC35F3 solute carrier family 35 member F3 [ Homo sapiens (human) ]

Gene ID: 148641, updated on 5-Mar-2024

Summary

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Official Symbol
SLC35F3provided by HGNC
Official Full Name
solute carrier family 35 member F3provided by HGNC
Primary source
HGNC:HGNC:23616
See related
Ensembl:ENSG00000183780 AllianceGenome:HGNC:23616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in thiamine transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 3.2), adrenal (RPKM 0.5) and 8 other tissues See more
Orthologs
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Genomic context

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See SLC35F3 in Genome Data Viewer
Location:
1q42.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (233904676..234324511)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (233291129..233714625)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (234040422..234460257)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985362 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:233843943-233845142 Neighboring gene uncharacterized LOC124904552 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:233859728-233860927 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:233865794-233866564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:233866565-233867336 Neighboring gene uncharacterized LOC107985363 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:234109180-234109382 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:234159353-234160552 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:234208561-234209760 Neighboring gene Rac family small GTPase 1 pseudogene 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:234289165-234289666 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:234323999-234324710 Neighboring gene Sharpr-MPRA regulatory region 1313 Neighboring gene uncharacterized LOC124904553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2746 Neighboring gene uncharacterized LOC105373206 Neighboring gene SLC35F3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10620 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6359 Neighboring gene ribosomal protein L9 pseudogene 10 Neighboring gene microRNA 4671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2750 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:234508390-234509214 Neighboring gene ribosomal protein S15 pseudogene 2 Neighboring gene COA6 antisense RNA 1 Neighboring gene cytochrome c oxidase assembly factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic implication of a novel thiamine transporter in human hypertension. Zhang K, et al. J Am Coll Cardiol, 2014 Apr 22. PMID 24509276, Free PMC Article
  2. CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma. Chen J, et al. J Cell Mol Med, 2021 Oct. PMID 34431227, Free PMC Article
  3. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article
  4. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37712

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in thiamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 35 member F3
Names
putative thiamine transporter SLC35F3
thiamine transporter SLC35F3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300845.2 → NP_001287774.1  solute carrier family 35 member F3 isoform 2

    See identical proteins and their annotated locations for NP_001287774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK095031, BC037878, DB468252
    Consensus CDS
    CCDS73050.1
    UniProtKB/Swiss-Prot
    Q5TDD6, Q8IY50, Q8N9C9
    Related
    ENSP00000355576.3, ENST00000366617.3
    Conserved Domains (2) summary
    pfam00892
    Location:67 → 223
    EamA; EamA-like transporter family
    pfam06027
    Location:165 → 338
    SLC35F; Solute carrier family 35

  2. NM_173508.4 → NP_775779.1  solute carrier family 35 member F3 isoform 1

    See identical proteins and their annotated locations for NP_775779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK095031, AL713868
    Consensus CDS
    CCDS1600.1
    UniProtKB/Swiss-Prot
    Q8IY50
    Related
    ENSP00000355577.3, ENST00000366618.8
    Conserved Domains (2) summary
    pfam00892
    Location:136 → 292
    EamA; EamA-like transporter family
    pfam06027
    Location:234 → 407
    SLC35F; Solute carrier family 35

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    233904676..234324511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    233291129..233714625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IY50.2 GenPept UniProtKB/Swiss-Prot:Q8IY50

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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