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PROSER3 proline and serine rich 3 [ Homo sapiens (human) ]

Gene ID: 148137, updated on 5-Mar-2024

Summary

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Official Symbol
PROSER3provided by HGNC
Official Full Name
proline and serine rich 3provided by HGNC
Primary source
HGNC:HGNC:25204
See related
Ensembl:ENSG00000167595 AllianceGenome:HGNC:25204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf55
Expression
Broad expression in testis (RPKM 6.2), appendix (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

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See PROSER3 in Genome Data Viewer
Location:
19q13.12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35758176..35771166)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38303488..38317285)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36249077..36262068)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36239246-36239760 Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene heat shock protein family B (small) member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268039-36268924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268925-36269809 Neighboring gene Rho GTPase activating protein 33 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36275082-36275900 Neighboring gene long intergenic non-protein coding RNA 1529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14503

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Zhang Y, et al. Cell Chem Biol, 2022 Jan 20. PMID 34672954, Free PMC Article
  2. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Gordon DE, et al. Science, 2020 Dec 4. PMID 33060197, Free PMC Article
  3. The human cytoplasmic dynein interactome reveals novel activators of motility. Redwine WB, et al. Elife, 2017 Jul 18. PMID 28718761, Free PMC Article
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  5. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Youn JY, et al. Mol Cell, 2018 Feb 1. PMID 29395067

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30657, MGC131952, DKFZp434C2231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proline and serine-rich protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039887.3 → NP_001034976.2  proline and serine-rich protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001034976.2

    Status: VALIDATED

    Source sequence(s)
    AC002398, BC110893, DB086668
    Consensus CDS
    CCDS46056.2
    UniProtKB/Swiss-Prot
    Q2NL68, Q8NDI3, Q8WWC8, Q96NL4
    Related
    ENSP00000380116.5, ENST00000396908.9

  2. NM_001367856.1 → NP_001354785.1  proline and serine-rich protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725
    Consensus CDS
    CCDS92595.1
    UniProtKB/TrEMBL
    A0A2R8Y8D9
    Related
    ENSP00000496769.2, ENST00000646935.2
    Conserved Domains (2) summary
    PHA03247
    Location:267 → 616
    PHA03247; large tegument protein UL36; Provisional
    PRK14951
    Location:393 → 512
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  3. NM_001395450.1 → NP_001382379.1  proline and serine-rich protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725
    Conserved Domains (1) summary
    PHA03247
    Location:244 → 615
    PHA03247; large tegument protein UL36; Provisional

  4. NM_001395451.1 → NP_001382380.1  proline and serine-rich protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725
    Conserved Domains (2) summary
    PHA03247
    Location:229 → 604
    PHA03247; large tegument protein UL36; Provisional
    PRK14951
    Location:381 → 500
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  5. NM_001395452.1 → NP_001382381.1  proline and serine-rich protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725
    Conserved Domains (1) summary
    PHA03247
    Location:159 → 530
    PHA03247; large tegument protein UL36; Provisional

  6. NM_001395453.1 → NP_001382382.1  proline and serine-rich protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725
    Conserved Domains (1) summary
    PHA03247
    Location:149 → 520
    PHA03247; large tegument protein UL36; Provisional

  7. NM_001395454.1 → NP_001382383.1  proline and serine-rich protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725
    Conserved Domains (1) summary
    PHA03247
    Location:134 → 505
    PHA03247; large tegument protein UL36; Provisional

  8. NM_001395455.1 → NP_001382384.1  proline and serine-rich protein 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725

  9. NM_001395456.1 → NP_001382385.1  proline and serine-rich protein 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC002398
    UniProtKB/TrEMBL
    C9JFW7
    Related
    ENSP00000301165.5, ENST00000301165.9

  10. NM_001395457.1 → NP_001382386.1  proline and serine-rich protein 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC002398

  11. NM_001395458.1 → NP_001382387.1  proline and serine-rich protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC002398, KF495725
    Consensus CDS
    CCDS92595.1
    UniProtKB/TrEMBL
    A0A2R8Y8D9
    Conserved Domains (2) summary
    PHA03247
    Location:267 → 616
    PHA03247; large tegument protein UL36; Provisional
    PRK14951
    Location:393 → 512
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35758176..35771166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438263.1 → XP_047294219.1  proline and serine-rich protein 3 isoform X12

  2. XM_011526533.4 → XP_011524835.1  proline and serine-rich protein 3 isoform X9

    See identical proteins and their annotated locations for XP_011524835.1

    Conserved Domains (1) summary
    PRK14951
    Location:400 → 519
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  3. XM_011526528.2 → XP_011524830.1  proline and serine-rich protein 3 isoform X1

    Conserved Domains (2) summary
    PRK12323
    Location:267 → 471
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    PRK14951
    Location:400 → 519
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  4. XM_011526532.2 → XP_011524834.1  proline and serine-rich protein 3 isoform X8

    Conserved Domains (1) summary
    PRK14951
    Location:400 → 519
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  5. XM_011526530.2 → XP_011524832.1  proline and serine-rich protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3WKY3
    Related
    ENSP00000512346.1, ENST00000696041.1
    Conserved Domains (1) summary
    PHA03247
    Location:267 → 616
    PHA03247; large tegument protein UL36; Provisional

  6. XM_011526531.2 → XP_011524833.1  proline and serine-rich protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A8Q3WKY6
    Related
    ENSP00000512347.1, ENST00000696042.1
    Conserved Domains (2) summary
    PRK12323
    Location:256 → 460
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    PRK14951
    Location:389 → 508
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  7. XM_047438264.1 → XP_047294220.1  proline and serine-rich protein 3 isoform X13

  8. XM_047438259.1 → XP_047294215.1  proline and serine-rich protein 3 isoform X6

  9. XM_047438261.1 → XP_047294217.1  proline and serine-rich protein 3 isoform X10

  10. XM_011526529.4 → XP_011524831.1  proline and serine-rich protein 3 isoform X2

    Conserved Domains (2) summary
    PRK12323
    Location:266 → 470
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    PRK14951
    Location:399 → 518
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  11. XM_047438258.1 → XP_047294214.1  proline and serine-rich protein 3 isoform X4

  12. XM_047438262.1 → XP_047294218.1  proline and serine-rich protein 3 isoform X11

  13. XM_047438260.1 → XP_047294216.1  proline and serine-rich protein 3 isoform X7

  14. XM_011526535.3 → XP_011524837.1  proline and serine-rich protein 3 isoform X14

    UniProtKB/TrEMBL
    A0A8Q3WKY7
    Related
    ENSP00000512345.1, ENST00000696040.1
    Conserved Domains (1) summary
    PHA03247
    Location:145 → 523
    PHA03247; large tegument protein UL36; Provisional

  15. XM_047438265.1 → XP_047294221.1  proline and serine-rich protein 3 isoform X15

  16. XM_047438267.1 → XP_047294223.1  proline and serine-rich protein 3 isoform X17

  17. XM_047438266.1 → XP_047294222.1  proline and serine-rich protein 3 isoform X16

  18. XM_011526536.4 → XP_011524838.1  proline and serine-rich protein 3 isoform X18

    UniProtKB/Swiss-Prot
    Q2NL68
    Related
    ENSP00000482508.1, ENST00000620918.4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38303488..38317285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319979.1 → XP_054175954.1  proline and serine-rich protein 3 isoform X12

  2. XM_054319968.1 → XP_054175943.1  proline and serine-rich protein 3 isoform X1

  3. XM_054319970.1 → XP_054175945.1  proline and serine-rich protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3WKY3

  4. XM_054319972.1 → XP_054175947.1  proline and serine-rich protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A8Q3WKY6

  5. XM_054319973.1 → XP_054175948.1  proline and serine-rich protein 3 isoform X6

  6. XM_054319969.1 → XP_054175944.1  proline and serine-rich protein 3 isoform X2

  7. XM_054319971.1 → XP_054175946.1  proline and serine-rich protein 3 isoform X4

  8. XM_054319974.1 → XP_054175949.1  proline and serine-rich protein 3 isoform X7

  9. XM_054319981.1 → XP_054175956.1  proline and serine-rich protein 3 isoform X14

    UniProtKB/TrEMBL
    A0A8Q3WKY7

  10. XM_054319976.1 → XP_054175951.1  proline and serine-rich protein 3 isoform X9

  11. XM_054319975.1 → XP_054175950.1  proline and serine-rich protein 3 isoform X8

  12. XM_054319980.1 → XP_054175955.1  proline and serine-rich protein 3 isoform X13

  13. XM_054319977.1 → XP_054175952.1  proline and serine-rich protein 3 isoform X10

  14. XM_054319978.1 → XP_054175953.1  proline and serine-rich protein 3 isoform X11

  15. XM_054319982.1 → XP_054175957.1  proline and serine-rich protein 3 isoform X15

  16. XM_054319984.1 → XP_054175959.1  proline and serine-rich protein 3 isoform X17

  17. XM_054319983.1 → XP_054175958.1  proline and serine-rich protein 3 isoform X16

  18. XM_054319985.1 → XP_054175960.1  proline and serine-rich protein 3 isoform X18

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144692.1: Suppressed sequence

    Description
    NM_144692.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2NL68.1 GenPept UniProtKB/Swiss-Prot:Q2NL68

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