U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grik3 glutamate receptor, ionotropic, kainate 3 [ Mus musculus (house mouse) ]

Gene ID: 14807, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Grik3provided by MGI
Official Full Name
glutamate receptor, ionotropic, kainate 3provided by MGI
Primary source
MGI:MGI:95816
See related
Ensembl:ENSMUSG00000001985 AllianceGenome:MGI:95816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluK3; Glur7; Glur-7; GluR7-3; 9630027E11
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Transcript variants encoding different isoforms have been described for this gene, however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in frontal lobe adult (RPKM 10.1), whole brain E14.5 (RPKM 9.8) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 D2.2; 4 58.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125384025..125607966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125490259..125714173)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11366 Neighboring gene predicted gene, 40247 Neighboring gene predicted gene, 32756 Neighboring gene STARR-seq mESC enhancer starr_11372 Neighboring gene microRNA 692-2 Neighboring gene STARR-seq mESC enhancer starr_11375 Neighboring gene ferritin light polypeptide 2, pseudogene Neighboring gene predicted gene, 32807 Neighboring gene STARR-seq mESC enhancer starr_11380 Neighboring gene predicted gene, 54257 Neighboring gene STARR-seq mESC enhancer starr_11383 Neighboring gene predicted gene, 40249 Neighboring gene RIKEN cDNA 2610028E06 gene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking. Huyghe D, et al. J Neurosci, 2011 Aug 10. PMID 21832194, Free PMC Article
  2. Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3. Pigoni M, et al. EMBO J, 2020 Aug 3. PMID 32567721, Free PMC Article
  3. The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain. Stayte S, et al. Exp Neurol, 2020 Jan. PMID 31513786
  4. Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. Schiffer HH, et al. J Neurosci, 2000 Dec 15. PMID 11124978, Free PMC Article
  5. Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina. Duvoisin RM, et al. Neurosci Lett, 1995 Jan 2. PMID 7538211

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
    Title: Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
  2. Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
    Title: Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
  3. loss of FMRP leads to the abnormal function and localization of kainite receptors.
    Title: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.
  4. Polarized trafficking of spliced variant GluK3b in neurons may be controlled by the regulation of receptor endocytosis.
    Title: Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking.
  5. GluR7, a kainate receptor (KAR) subunit with no known function in the brain, is identified as an essential subunit of presynaptic autoreceptors that facilitate hippocampal mossy fiber synaptic transmission.
    Title: GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
  6. GluR7 kainate receptor subunit splice variants differentially traffic from the ER to the plasma membrane
    Title: Differential trafficking of GluR7 kainate receptor subunit splice variants.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamate-gated receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables kainate selective glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kainate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEP
Inferred from Expression Pattern
more info
 PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glutamate receptor ionotropic, kainate 3
Names
glutamate receptor 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081097.3 → NP_001074566.1  glutamate receptor ionotropic, kainate 3 precursor

    See identical proteins and their annotated locations for NP_001074566.1

    Status: REVIEWED

    Source sequence(s)
    AL607090, AL627328
    Consensus CDS
    CCDS38878.1
    UniProtKB/Swiss-Prot
    B1AS29, Q17R20, Q9JIA8
    Related
    ENSMUSP00000030676.8, ENSMUST00000030676.8
    Conserved Domains (2) summary
    cd06393
    Location:34 → 417
    PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
    cd13723
    Location:433 → 801
    PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125384025..125607966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502772.4 → XP_006502835.1  glutamate receptor ionotropic, kainate 3 isoform X1

    Conserved Domains (2) summary
    cd13723
    Location:433 → 801
    PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily
    cd06382
    Location:37 → 417
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

  2. XM_036163688.1 → XP_036019581.1  glutamate receptor ionotropic, kainate 3 isoform X3

    Conserved Domains (2) summary
    cd06382
    Location:37 → 417
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:433 → 697
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  3. XM_017319980.3 → XP_017175469.1  glutamate receptor ionotropic, kainate 3 isoform X2

    Conserved Domains (2) summary
    cd06382
    Location:37 → 417
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:443 → 733
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AS29.1 GenPept UniProtKB/Swiss-Prot:B1AS29

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous