Grid2 glutamate receptor, ionotropic, delta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grid2provided by MGI
Official Full Name: glutamate receptor, ionotropic, delta 2provided by MGI
Primary source: MGI:MGI:95813
See related: Ensembl:ENSMUSG00000071424 AllianceGenome:MGI:95813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lc; ho; cpr; tpr; GluD2; Lc<J>; Ms10ac; nmf408; MMS10-AC; GluRdelta2; B230104L07Rik
Summary: Enables PDZ domain binding activity and scaffold protein binding activity. Involved in several processes, including cerebellar granule cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and regulation of postsynaptic density assembly. Acts upstream of or within several processes, including chemical synaptic transmission; prepulse inhibition; and regulation of neuron apoptotic process. Located in dendritic spine and postsynaptic membrane. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including brain; eye; genitourinary system; intestine; and spinal cord. Used to study autosomal recessive spinocerebellar ataxia 18. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 10.0), whole brain E14.5 (RPKM 1.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 29.77 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (63230118..64681305)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (63256006..64704321)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRID2 aberration leads to disturbance in neuroactive ligand-receptor interactions via changes to the species richness and composition of gut microbes.
Title: GRID2 aberration leads to disturbance in neuroactive ligand-receptor interactions via changes to the species richness and composition of gut microbes.
GluD2- and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells.
Title: GluD2- and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells.
Stau2 downregulation (Stau2(GT)) led to an increase of glutamate receptor ionotropic delta subunit 2 (GluD2) in Purkinje cells when animals performed physical activity by voluntary wheel running compared with the age-matched wildtype (WT) mice (C57Bl/6J).
Title: Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain.
GLUD2 transgenic mice were generated by inserting in their genome, a segment of the human X chromosome containing the GLUD2 gene and its promoter.
Title: Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution.
Results suggest that the GluRdelta2 receptor plays an important role in the long-term organization of the granule-Purkinje cell circuit through its involvement in the regulation of parallel fiber-Purkinje cell synaptogenesis and in the normal functioning of this critical cerebellar circuit.
Title: Deletion of the GluRδ2 Receptor in the Hotfoot Mouse Mutant Causes Granule Cell Loss, Delayed Purkinje Cell Death, and Reductions in Purkinje Cell Dendritic Tree Area.
The GluD2 mutation in the ho15J mice affects stable retention of the acquired conditioned bradycardia.
Title: Involvement of GluD2 in Fear-Conditioned Bradycardia in Mice.
Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis.
Title: Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development.
This study showed that spontaneous Grid2 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
Title: Behavioral effects of neonatal lesions on the cerebellar system.
Established is a mouse line with an autosomal recessive gene mutation characterized by progressive ataxia and significant cerebellar atrophy.
Title: A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia.
GluD2 works in concert with GluD1 for the construction of cerebellar synaptic wiring through distinct neuronal and synaptic expressions.
Title: Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (23) 1 citation
Transgenic (2) 1 citation
Targeted (7) 1 citation
Chemically induced (ENU) (3)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Rck301 (e-PCR), detects polymorphism
- UniSTS:142605

D6Rck314 (e-PCR), detects polymorphism
- UniSTS:142606

24.MMHAP88FLH3.seq (e-PCR)
- UniSTS:123662

D6Rck317 (e-PCR), detects polymorphism
- UniSTS:142608

D6Rck324 (e-PCR), detects polymorphism
- UniSTS:142609

D6Rck325 (e-PCR), detects polymorphism
- UniSTS:142610

D6Rck344 (e-PCR), detects polymorphism
- UniSTS:142616

D6Rck345 (e-PCR), detects polymorphism
- UniSTS:142617

D6Rck346 (e-PCR), detects polymorphism
- UniSTS:142618

D6Rck347 (e-PCR), detects polymorphism
- UniSTS:142619

D6Rck354 (e-PCR), detects polymorphism
- UniSTS:142621

D6Rck357 (e-PCR), detects polymorphism
- UniSTS:142623

D6Rck358 (e-PCR), detects polymorphism
- UniSTS:142624

D6Rck359 (e-PCR), detects polymorphism
- UniSTS:142625

D6Rck360 (e-PCR), detects polymorphism
- UniSTS:142626

D6Rck362 (e-PCR), detects polymorphism
- UniSTS:142628

D6Rck365 (e-PCR), detects polymorphism
- UniSTS:142630

RH118302 (e-PCR)
- UniSTS:123488

AI450142 (e-PCR)
- UniSTS:207969

32.MMHAP88FLC5.seq (e-PCR)
- UniSTS:124006

D4M6Mit121 (e-PCR)
- UniSTS:130663

D6Mit121 (e-PCR), detects polymorphism
- UniSTS:130663

Grid2 (e-PCR), detects polymorphism
- UniSTS:143255

Grid2 (e-PCR), detects polymorphism
- UniSTS:143256

Grid2 (e-PCR), detects polymorphism
- UniSTS:143257

Grid2 (e-PCR), detects polymorphism
- UniSTS:143258

29.MHAa92c5.seq (e-PCR)
- UniSTS:123846

40.MMHAP64FRF10.seq (e-PCR)
- UniSTS:124375

BF390815 (e-PCR)
- UniSTS:249581

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cerebellar granule cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of ionotropic glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, delta-2

Names: creeper; gluR delta-2 subunit; glutamate receptor delta-2 subunit; hotfoot; lurcher; minisatellite 10ac detected by probe MMS10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370966.1 → NP_001357895.1 glutamate receptor ionotropic, delta-2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC093476, AC122802, AC123852, AC131711, AC134622, AC138621, AC158380, AC162924, AC168092

Conserved Domains (2) summary

cd13731
Location:440 → 806

PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:28 → 429

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
NM_008167.3 → NP_032193.1 glutamate receptor ionotropic, delta-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_032193.1

Status: VALIDATED

Source sequence(s)

AC093476, AC122802, AC123852, AC131711, AC134622, AC138621, AC158380, AC168092

Consensus CDS

CCDS20202.1

UniProtKB/Swiss-Prot

A4QPG1, Q61625

Related

ENSMUSP00000093536.4, ENSMUST00000095852.5

Conserved Domains (2) summary

cd13731
Location:440 → 806

PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:28 → 429

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

63230118..64681305

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165857.1 → XP_036021750.1 glutamate receptor ionotropic, delta-2 isoform X1

Conserved Domains (2) summary

cd13731
Location:440 → 806

PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:28 → 429

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily