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Grid1 glutamate receptor, ionotropic, delta 1 [ Mus musculus (house mouse) ]

Gene ID: 14803, updated on 11-Apr-2024

Summary

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Official Symbol
Grid1provided by MGI
Official Full Name
glutamate receptor, ionotropic, delta 1provided by MGI
Primary source
MGI:MGI:95812
See related
Ensembl:ENSMUSG00000041078 AllianceGenome:MGI:95812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluD1; GluRdelta1
Summary
Predicted to enable glutamate receptor activity; identical protein binding activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in social behavior. Located in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; liver and biliary system; reproductive system; and spinal cord. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.3), frontal lobe adult (RPKM 4.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 20.84 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34541751..35305344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34820003..35583387)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930038B10 gene Neighboring gene STARR-seq mESC enhancer starr_36402 Neighboring gene STARR-seq mESC enhancer starr_36403 Neighboring gene predicted gene, 52101 Neighboring gene predicted gene, 30969 Neighboring gene microRNA 346 Neighboring gene STARR-seq mESC enhancer starr_36406 Neighboring gene predicted gene, 41133 Neighboring gene STARR-seq mESC enhancer starr_36407 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_36408 Neighboring gene STARR-seq mESC enhancer starr_36409 Neighboring gene STARR-seq mESC enhancer starr_36410 Neighboring gene STARR-seq mESC enhancer starr_36411 Neighboring gene RIKEN cDNA 4930596D02 gene Neighboring gene sorting nexin 15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate δ1 receptor. Yadav R, et al. Brain Res, 2011 Mar 25. PMID 21215726
  2. Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain. Gandhi PJ, et al. Cells, 2021 Oct 3. PMID 34685624, Free PMC Article
  3. Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens. Liu J, et al. Transl Psychiatry, 2018 Oct 12. PMID 30315226, Free PMC Article
  4. Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus. Suryavanshi PS, et al. Mol Pharmacol, 2016 Aug. PMID 27231330, Free PMC Article
  5. Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning. Yadav R, et al. PLoS One, 2013. PMID 23560106, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain.
    Title: Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain.
  2. Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity.
    Title: Striatal glutamate delta-1 receptor regulates behavioral flexibility and thalamostriatal connectivity.
  3. Study found that glutamate delta-1 KO mice have higher preference for cocaine in conditioned place preference test and exhibit significantly more cocaine-induced structural plasticity and spine maturation compared to wildtype.
    Title: Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.
  4. GluD1 interacts with mGlu5, and loss of GluD1 impairs normal mGlu5 signaling potentially by dysregulating coupling to its effector.
    Title: Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus.
  5. Deletion of GluD1 leads to aberrant circuitry in prefrontal cortex and amygdala. Furthermore, these findings are in agreement with the human genetic studies suggesting a strong association of GRID1 gene with several neuropsychiatric disorders.
    Title: Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors.
  6. GluRdelta1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with pre-synaptic neurexins containing splice segment 4 through Cbln subtypes.
    Title: Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
  7. The residues in the highly conserved SYTANLAAF region form the activation gate for GluRdelta1, since mutations in a set of closely arranged residues are found to generate spontaneously open channels.
    Title: Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate δ1 receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate receptor ionotropic, delta-1
Names
gluR delta-1 subunit
glutamate receptor delta-1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008166.2 → NP_032192.2  glutamate receptor ionotropic, delta-1 precursor

    See identical proteins and their annotated locations for NP_032192.2

    Status: VALIDATED

    Source sequence(s)
    AC154730, AK138279, BM899969, DN176234
    Consensus CDS
    CCDS26944.1
    UniProtKB/Swiss-Prot
    Q3UUL5, Q61627
    Related
    ENSMUSP00000044009.6, ENSMUST00000043349.7
    Conserved Domains (2) summary
    cd06392
    Location:25 → 423
    PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
    cd13730
    Location:436 → 806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34541751..35305344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244962.4 → XP_011243264.1  glutamate receptor ionotropic, delta-1 isoform X2

    Conserved Domains (2) summary
    cd13730
    Location:436 → 806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    cd06392
    Location:25 → 425
    PBP1_iGluR_delta_1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family

  2. XM_006518565.4 → XP_006518628.1  glutamate receptor ionotropic, delta-1 isoform X1

    Conserved Domains (2) summary
    cd13730
    Location:341 → 711
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:25 → 330
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  3. XM_006518566.4 → XP_006518629.1  glutamate receptor ionotropic, delta-1 isoform X3

    Conserved Domains (2) summary
    cd13730
    Location:225 → 595
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:1 → 214
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61627.2 GenPept UniProtKB/Swiss-Prot:Q61627

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