Tle5 TLE family member 5, transcriptional modulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tle5provided by MGI
Official Full Name: TLE family member 5, transcriptional modulatorprovided by MGI
Primary source: MGI:MGI:95806
See related: Ensembl:ENSMUSG00000054452 AllianceGenome:MGI:95806
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aes; Grg; Esp1; Grg5; Grg-5
Summary: This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in adrenal adult (RPKM 1208.9), duodenum adult (RPKM 833.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81395278..81402205)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81559444..81566371)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unrevealed roles of extracellular enolase-1 (ENO1) in promoting glycolysis and pro-cancer activities in multiple myeloma via hypoxia-inducible factor 1alpha.
Title: Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α.
The results demonstrate that GRG5 has pleiotropic roles in stem cell biology functioning as a stemness factor and a neural fate specifier.
Title: Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions.
in a transplantation mouse model of liver metastases, expression of Yy2 (and therefore of Aes) is downregulated
Title: Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
The finding that Foxh1-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions.
Title: Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning.
Self-renewal induced by AML1/ETO in primary murine progenitors was inhibited when Aes was decreased or absent.
Title: AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.
The Aes gene functions as an endogenous metastasis suppressor. Aes inhibits Notch signaling by converting active Rbpj transcription complexes into repression complexes on insoluble nuclear matrix.
Title: Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.
direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothalamic neurons
Title: Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors.
Grg5 acts as a positive regulator of Runx2 activity and is necessary for full expression and signalling of Indian hedgehog (Ihh).
Title: Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice.
Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity.
Title: The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.
Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1
Title: TCF and Groucho-related genes influence pituitary growth and development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125487 (e-PCR)
- UniSTS:162306

NoName (e-PCR)
- UniSTS:532261

Aes (e-PCR), detects polymorphism
- UniSTS:532261

Aes (e-PCR), detects polymorphism
- UniSTS:498794

L12140 (e-PCR)
- UniSTS:180084

RH127590 (e-PCR)
- UniSTS:210900

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TLE family member 5

Names: amino-terminal enhancer of split; groucho-related protein 5; related to Drosophila groucho

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276288.1 → NP_001263217.1 TLE family member 5 isoform 2

See identical proteins and their annotated locations for NP_001263217.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AK158714, BC145299, BQ174071, BY713872

UniProtKB/TrEMBL

B7ZNK7

Conserved Domains (1) summary

pfam03920
Location:11 → 131

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_010347.4 → NP_034477.1 TLE family member 5 isoform 1

See identical proteins and their annotated locations for NP_034477.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK158714, BQ174071, BY713872

Consensus CDS

CCDS24062.1

UniProtKB/Swiss-Prot

P63002, Q06195

UniProtKB/TrEMBL

Q3TYD9

Related

ENSMUSP00000002518.9, ENSMUST00000002518.9

Conserved Domains (1) summary

pfam03920
Location:11 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain

RNA

NR_074087.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK158714, BE685863, BQ174071, BY713872