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IGFL2 IGF like family member 2 [ Homo sapiens (human) ]

Gene ID: 147920, updated on 5-Mar-2024

Summary

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Official Symbol
IGFL2provided by HGNC
Official Full Name
IGF like family member 2provided by HGNC
Primary source
HGNC:HGNC:32929
See related
Ensembl:ENSG00000204866 MIM:610545; AllianceGenome:HGNC:32929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ645; VPRI645
Summary
IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in skin (RPKM 2.9) and testis (RPKM 1.1) See more
Orthologs
all
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Genomic context

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Location:
19q13.32
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46078513..46215362)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48905965..49042808)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46651039..46664546)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46535831-46536434 Neighboring gene IGF like family member 4 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46636065-46636896 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:46636897-46637728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46637729-46638559 Neighboring gene IGF like family member 3 Neighboring gene TGFB induced factor homeobox 1 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:46662347-46663546 Neighboring gene uncharacterized LOC105372424 Neighboring gene NANOG hESC enhancer GRCh37_chr19:46673889-46674439 Neighboring gene Sharpr-MPRA regulatory region 10795 Neighboring gene IGFL2 antisense RNA 1 Neighboring gene IGF like family member 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 8129 Neighboring gene uncharacterized LOC93429 Neighboring gene MPRA-validated peak3520 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:46732347-46733546 Neighboring gene ribosomal protein L12 pseudogene 41 Neighboring gene IGF like family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. Emtage P, et al. Genomics, 2006 Oct. PMID 16890402
  2. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. Lobito AA, et al. J Biol Chem, 2011 May 27. PMID 21454693, Free PMC Article
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC007193.6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
insulin growth factor-like family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002915.3 → NP_001002915.2  insulin growth factor-like family member 2 isoform a precursor

    See identical proteins and their annotated locations for NP_001002915.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC007785, AW009166, AY672112, BC130490
    Consensus CDS
    CCDS46122.1
    UniProtKB/Swiss-Prot
    Q6UWQ7
    Related
    ENSP00000395219.1, ENST00000434646.6
    Conserved Domains (1) summary
    pfam14653
    Location:41 → 123
    IGFL; Insulin growth factor-like family

  2. NM_001135113.2 → NP_001128585.1  insulin growth factor-like family member 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001128585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) that has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC007785, AW009166, AY358692, BC130490
    Consensus CDS
    CCDS46121.1
    UniProtKB/Swiss-Prot
    E9PAV1, Q6B9Z3, Q6UWQ7
    Related
    ENSP00000366922.3, ENST00000377693.5
    Conserved Domains (1) summary
    pfam14653
    Location:24 → 112
    IGFL; Insulin growth factor-like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46078513..46215362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438228.1 → XP_047294184.1  insulin growth factor-like family member 2 isoform X2

  2. XM_024451381.2 → XP_024307149.1  insulin growth factor-like family member 2 isoform X2

    Conserved Domains (1) summary
    pfam14653
    Location:41 → 123
    IGFL; Insulin growth factor-like family

  3. XM_047438227.1 → XP_047294183.1  insulin growth factor-like family member 2 isoform X1

RNA

  1. XR_007066605.1 RNA Sequence

  2. XR_935743.3 RNA Sequence

  3. XR_001753605.1 RNA Sequence

  4. XR_001753604.1 RNA Sequence

  5. XR_007066604.1 RNA Sequence

  6. XR_007066606.1 RNA Sequence

  7. XR_007066608.1 RNA Sequence

  8. XR_007066610.1 RNA Sequence

  9. XR_002958257.2 RNA Sequence

  10. XR_007066607.1 RNA Sequence

  11. XR_007066612.1 RNA Sequence

  12. XR_007066609.1 RNA Sequence

  13. XR_007066614.1 RNA Sequence

  14. XR_007066615.1 RNA Sequence

  15. XR_007066611.1 RNA Sequence

  16. XR_007066613.1 RNA Sequence

  17. XR_002958269.2 RNA Sequence

  18. XR_007066616.1 RNA Sequence

  19. XR_007066617.1 RNA Sequence

  20. XR_002958271.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48905965..49042808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319899.1 → XP_054175874.1  insulin growth factor-like family member 2 isoform X2

  2. XM_054319904.1 → XP_054175879.1  insulin growth factor-like family member 2 isoform X2

  3. XM_054319900.1 → XP_054175875.1  insulin growth factor-like family member 2 isoform X2

  4. XM_054319905.1 → XP_054175880.1  insulin growth factor-like family member 2 isoform X2

  5. XM_054319901.1 → XP_054175876.1  insulin growth factor-like family member 2 isoform X2

  6. XM_054319903.1 → XP_054175878.1  insulin growth factor-like family member 2 isoform X1

  7. XM_054319902.1 → XP_054175877.1  insulin growth factor-like family member 2 isoform X2

RNA

  1. XR_008485090.1 RNA Sequence

  2. XR_008485089.1 RNA Sequence

  3. XR_008485088.1 RNA Sequence

  4. XR_008485091.1 RNA Sequence

  5. XR_008485094.1 RNA Sequence

  6. XR_008485096.1 RNA Sequence

  7. XR_008485093.1 RNA Sequence

  8. XR_008485092.1 RNA Sequence

  9. XR_008485098.1 RNA Sequence

  10. XR_008485095.1 RNA Sequence

  11. XR_008485100.1 RNA Sequence

  12. XR_008485102.1 RNA Sequence

  13. XR_008485097.1 RNA Sequence

  14. XR_008485099.1 RNA Sequence

  15. XR_008485101.1 RNA Sequence

  16. XR_008485103.1 RNA Sequence

  17. XR_008485104.1 RNA Sequence

  18. XR_007089175.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWQ7.1 GenPept UniProtKB/Swiss-Prot:Q6UWQ7

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