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DACT3 dishevelled binding antagonist of beta catenin 3 [ Homo sapiens (human) ]

Gene ID: 147906, updated on 5-Mar-2024

Summary

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Official Symbol
DACT3provided by HGNC
Official Full Name
dishevelled binding antagonist of beta catenin 3provided by HGNC
Primary source
HGNC:HGNC:30745
See related
Ensembl:ENSG00000197380 MIM:611112; AllianceGenome:HGNC:30745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRR1; DAPPER3
Summary
Predicted to enable delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cell growth. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 11.1), endometrium (RPKM 7.4) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19q13.32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46647551..46661182, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49473085..49486718, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47150808..47164439, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calmodulin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47119779-47120280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47120281-47120780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47124126-47124640 Neighboring gene prostaglandin I2 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47128561-47129061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10816 Neighboring gene Sharpr-MPRA regulatory region 2120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10818 Neighboring gene G protein subunit gamma 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47157789-47158515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10821 Neighboring gene DACT3 antisense RNA 1 Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47200828-47201328 Neighboring gene microRNA 320e

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/β-catenin signaling by DVL2. Gao Q, et al. J Biochem Mol Toxicol, 2022 May. PMID 35187752
  2. Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3. Lenoir M, et al. Gut Microbes, 2020 Nov 9. PMID 33054518, Free PMC Article
  3. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Jiang X, et al. Cancer Cell, 2008 Jun. PMID 18538736, Free PMC Article
  4. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. Fisher DA, et al. Dev Dyn, 2006 Sep. PMID 16881060
  5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. Kivimäe S, et al. BMC Biochem, 2011 Jun 30. PMID 21718540, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/beta-catenin signaling by DVL2.
    Title: DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/β-catenin signaling by DVL2.
  2. Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3.
    Title: Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3.
  3. Epigenetic repression of DACT3 leads to aberrant Wnt-beta-catenin signaling in colorectal cancer cells.
    Title: DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC15476

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables delta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dapper homolog 3
Names
antagonist of beta-catenin Dapper homolog 3
arginine-rich region 1 protein
dapper, antagonist of beta-catenin, homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301046.2 → NP_001287975.1  dapper homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_001287975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093503, AI769079, BC016161, BE274342, BF515069, BX097198
    Consensus CDS
    CCDS74402.1
    UniProtKB/TrEMBL
    A0A0C4DFP1
    Related
    ENSP00000300875.4, ENST00000300875.4
    Conserved Domains (1) summary
    pfam15268
    Location:22 → 404
    Dapper; Dapper

  2. NM_145056.3 → NP_659493.2  dapper homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_659493.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093503
    Consensus CDS
    CCDS12688.2
    UniProtKB/Swiss-Prot
    Q96B18
    Related
    ENSP00000375783.2, ENST00000391916.7
    Conserved Domains (1) summary
    pfam15268
    Location:20 → 629
    Dapper; Dapper

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46647551..46661182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526499.3 → XP_011524801.1  dapper homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_011524801.1

    UniProtKB/TrEMBL
    A0A0C4DFP1
    Conserved Domains (1) summary
    pfam15268
    Location:22 → 404
    Dapper; Dapper

  2. XM_017026334.2 → XP_016881823.1  dapper homolog 3 isoform X1

  3. XM_011526500.3 → XP_011524802.1  dapper homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_011524802.1

    UniProtKB/TrEMBL
    A0A0C4DFP1
    Conserved Domains (1) summary
    pfam15268
    Location:22 → 404
    Dapper; Dapper

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49473085..49486718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319897.1 → XP_054175872.1  dapper homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DFP1

  2. XM_054319896.1 → XP_054175871.1  dapper homolog 3 isoform X1

  3. XM_054319898.1 → XP_054175873.1  dapper homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DFP1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96B18.2 GenPept UniProtKB/Swiss-Prot:Q96B18

Gene LinkOut

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