Gpr50 G-protein-coupled receptor 50 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr50provided by MGI
Official Full Name: G-protein-coupled receptor 50provided by MGI
Primary source: MGI:MGI:1333877
See related: Ensembl:ENSMUSG00000056380 AllianceGenome:MGI:1333877
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H9
Summary: This gene encodes a multipass membrane protein that is thought to act as a G protein-coupled receptor. Activity of this protein may be important in neurotransmitter and glucocorticoid signalling. Mutation of this gene causes a decreased ability to maintain a constant body temperature, resulting in torpor, as well as an increased metabolic rate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression: Biased expression in placenta adult (RPKM 5.5), whole brain E14.5 (RPKM 1.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 36.98 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (70707273..70712863)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (71663667..71669257)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes.
Title: Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes.
GPR50 is a TbetaRI co-receptor with potential impact on cancer development
Title: The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development.
GPR50 promotes neuronal differentiation through its intracellular domain.
Title: G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/β-catenin signalings.
A link is identified between GPR50 expression and neurotransmitter signaling during brain development.
Title: Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain.
Data indicate that Txnip expression is increased in the hypothalamus of Gpr50-/- mice during torpor.
Title: Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.
GPR50 is a component of adaptive thermogenesis in mice
Title: A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor.
An enlarged distribution of GPR50 protein in the brain.
Title: Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains.
Data demonstrate that GPR50 can enhance TIP60-coactiavtion of glucocorticoid receptor (GR) signalling.
Title: GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.
Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus.
Title: Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence.
GPR50 is an important regulator of energy metabolism
Title: Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Gpr50 (e-PCR), detects polymorphism
- UniSTS:143245

NoName (e-PCR)
- UniSTS:238034

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melatonin receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melatonin-related receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308501.1 → NP_001295430.1 melatonin-related receptor isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate segment, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK132272, BC145080, BQ032613

UniProtKB/Swiss-Prot

O88495

Conserved Domains (2) summary

pfam00001
Location:53 → 224

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:44 → 189

7tm_4; Olfactory receptor
NM_010340.2 → NP_034470.1 melatonin-related receptor isoform 1

See identical proteins and their annotated locations for NP_034470.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK132272, AL840624, BQ032613

Consensus CDS

CCDS30181.1

UniProtKB/Swiss-Prot

O88495, Q3V1S8

Related

ENSMUSP00000064608.6, ENSMUST00000070449.6

Conserved Domains (2) summary

pfam00001
Location:53 → 302

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:44 → 189

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

70707273..70712863

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527827.3 → XP_006527890.1 melatonin-related receptor isoform X1

Conserved Domains (2) summary

cd14964
Location:27 → 57

7tm_GPCRs; TM helix 3 [structural motif]

cl28897
Location:1 → 231

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily