Pdpn podoplanin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdpnprovided by MGI
Official Full Name: podoplaninprovided by MGI
Primary source: MGI:MGI:103098
See related: Ensembl:ENSMUSG00000028583 AllianceGenome:MGI:103098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E11; T1a; Gp38; OTS-8; T1alpha; RANDAM-2; T1-alpha
Summary: Predicted to enable chaperone binding activity; chemokine binding activity; and signaling receptor binding activity. Involved in several processes, including lymph node development; lymphatic endothelial cell fate commitment; and positive regulation of platelet aggregation. Acts upstream of or within several processes, including lung alveolus development; lymphangiogenesis; and prostaglandin metabolic process. Located in several cellular components, including external side of plasma membrane; lamellipodium; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; hemolymphoid system; and reproductive system. Orthologous to human PDPN (podoplanin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 24.1), placenta adult (RPKM 24.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E1; 4 77.29 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (142993979..143026134, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (143267409..143299564, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis.
Title: The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis.
Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma.
Title: Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma.
Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection.
Title: Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection.
Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background.
Title: Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background.
FGF7-induced E11 facilitates cell-cell communication through connexin43.
Title: FGF7-induced E11 facilitates cell-cell communication through connexin43.
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
Title: CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin.
Title: Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin.
A Role of the Podoplanin-CLEC-2 Axis in Promoting Inflammatory Response After Ischemic Stroke in Mice.
Title: A Role of the Podoplanin-CLEC-2 Axis in Promoting Inflammatory Response After Ischemic Stroke in Mice.
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.
Title: Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.
Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction.
Title: Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

PMC343810P4 (e-PCR)
- UniSTS:273195

RH126585 (e-PCR)
- UniSTS:207715

NoName (e-PCR)
- UniSTS:224675

M73748 (e-PCR)
- UniSTS:179109

Pdpn (e-PCR), detects polymorphism
- UniSTS:496834

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine binding	ISO Inferred from Sequence Orthology more info
NOT enables folic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
NOT enables water channel activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables water transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in actin-mediated cell contraction	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in folic acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphatic endothelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of platelet aggregation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of myofibroblast contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in visceral serous pericardium development	TAS Traceable Author Statement more info	PubMed
NOT acts_upstream_of_or_within water transport	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in leading edge of lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in tetraspanin-enriched microdomain	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: podoplanin

Names: PA2.26 antigen; aggrus; glycoprotein 38; transmembrane glycoprotein E11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290822.1 → NP_001277751.1 podoplanin isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AK158855, AL611982, CX240531

Consensus CDS

CCDS71511.1

UniProtKB/TrEMBL

A8Y5F6

Related

ENSMUSP00000113776.2, ENSMUST00000119654.2

Conserved Domains (1) summary

pfam05808
Location:1 → 158

Podoplanin; Podoplanin
NM_010329.3 → NP_034459.2 podoplanin isoform 1 precursor

See identical proteins and their annotated locations for NP_034459.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK158855, AL611982

Consensus CDS

CCDS38943.1

UniProtKB/Swiss-Prot

A2A8J3, Q546R8, Q61612, Q62011

Related

ENSMUSP00000030317.8, ENSMUST00000030317.14

Conserved Domains (1) summary

pfam05808
Location:1 → 171

Podoplanin; Podoplanin