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Gng5 G protein subunit gamma 5 [ Mus musculus (house mouse) ]

Gene ID: 14707, updated on 14-Dec-2024

Summary

Official Symbol
Gng5provided by MGI
Official Full Name
G protein subunit gamma 5provided by MGI
Primary source
MGI:MGI:109164
See related
Ensembl:ENSMUSG00000068523 AllianceGenome:MGI:109164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G(y)5
Summary
Predicted to enable G-protein beta-subunit binding activity and PDZ domain binding activity. Acts upstream of or within positive regulation of neural precursor cell proliferation and positive regulation of secondary heart field cardioblast proliferation. Located in mitochondrion. Is expressed in several structures, including cerebellum; early conceptus; oocyte; and retina. Orthologous to human GNG5 (G protein subunit gamma 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 121.2), testis adult (RPKM 120.0) and 28 other tissues See more
Orthologs
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Genomic context

See Gng5 in Genome Data Viewer
Location:
3 H2; 3 71.54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146205591..146211298)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146499836..146505543)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SSX family member 2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9230 Neighboring gene chitobiase Neighboring gene spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E6144 Neighboring gene STARR-positive B cell enhancer ABC_E11229 Neighboring gene ribosome production factor 1 homolog Neighboring gene deoxyribonuclease II beta Neighboring gene STARR-seq mESC enhancer starr_09227 Neighboring gene urate oxidase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding  
enables G-protein beta-subunit binding  
enables PDZ domain binding PubMed 
Component Evidence Code Pubs
part_of G-protein beta/gamma-subunit complex PubMed 
part_of heterotrimeric G-protein complex  
part_of heterotrimeric G-protein complex  
located_in mitochondrion PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Names
guanine nucleotide binding protein (G protein), gamma 5 subunit
NP_034448.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010318.2NP_034448.2  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

    See identical proteins and their annotated locations for NP_034448.2

    Status: VALIDATED

    Source sequence(s)
    AK146065, BY132164
    Consensus CDS
    CCDS17903.1
    UniProtKB/Swiss-Prot
    Q5I0W4, Q80SZ7
    UniProtKB/TrEMBL
    A0A3B2WD42, Q3UKC8
    Related
    ENSMUSP00000087485.6, ENSMUST00000090031.12
    Conserved Domains (1) summary
    cd00068
    Location:763
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146205591..146211298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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