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CD300LG CD300 molecule like family member g [ Homo sapiens (human) ]

Gene ID: 146894, updated on 5-Mar-2024

Summary

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Official Symbol
CD300LGprovided by HGNC
Official Full Name
CD300 molecule like family member gprovided by HGNC
Primary source
HGNC:HGNC:30455
See related
Ensembl:ENSG00000161649 MIM:610520; AllianceGenome:HGNC:30455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM9; CLM-9; TREM4; TREM-4; NEPMUCIN
Summary
Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in fat (RPKM 45.4), placenta (RPKM 12.3) and 3 other tissues See more
Orthologs
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Genomic context

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See CD300LG in Genome Data Viewer
Location:
17q21.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43847176..43863639)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44699730..44716193)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41924544..41941007)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MAGUK p55 scaffold protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8569 Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41943686-41943858 Neighboring gene Sharpr-MPRA regulatory region 5434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959115-41959616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959617-41960116 Neighboring gene MAGUK p55 scaffold protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41991041-41991541 Neighboring gene uncharacterized LOC105371787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41994398-41995219 Neighboring gene family with sequence similarity 215 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression Depression of CD300LG-γ in Human Pulmonary Carcinoma. Zhai S, et al. Monoclon Antib Immunodiagn Immunother, 2016 Apr. PMID 26977771
  2. Blood pressure levels in male carriers of Arg82Cys in CD300LG. Støy J, et al. PLoS One, 2014. PMID 25314291, Free PMC Article
  3. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. Umemoto E, et al. J Exp Med, 2006 Jun 12. PMID 16754720, Free PMC Article
  4. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. Takatsu H, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16876123
  5. The CD300 molecules regulate monocyte and dendritic cell functions. Clark GJ, et al. Immunobiology, 2009. PMID 19592130

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
CMRF35-like molecule 9
Names
CD300 antigen-like family member G
triggering receptor expressed on myeloid cells 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168322.2 → NP_001161794.1  CMRF35-like molecule 9 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AK309938
    Consensus CDS
    CCDS54131.1
    UniProtKB/Swiss-Prot
    Q6UXG3
    Related
    ENSP00000442368.1, ENST00000539718.5
    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

  2. NM_001168323.2 → NP_001161795.1  CMRF35-like molecule 9 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015937, AK298112, AK309938
    Consensus CDS
    CCDS54132.1
    UniProtKB/Swiss-Prot
    Q6UXG3
    Related
    ENSP00000366408.3, ENST00000377203.8
    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

  3. NM_001168324.2 → NP_001161796.1  CMRF35-like molecule 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015937, AF427619
    Consensus CDS
    CCDS54133.1
    UniProtKB/Swiss-Prot
    Q6UXG3
    Related
    ENSP00000293396.7, ENST00000293396.12
    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

  4. NM_001411122.1 → NP_001398051.1  CMRF35-like molecule 9 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC007993, AC015937
    Consensus CDS
    CCDS92332.1
    UniProtKB/TrEMBL
    A0A8V8TQK5
    Related
    ENSP00000515157.1, ENST00000700726.1

  5. NM_145273.4 → NP_660316.2  CMRF35-like molecule 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_660316.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007993, AC015937, AK298112, AY358364, BC025395
    Consensus CDS
    CCDS11470.1
    UniProtKB/Swiss-Prot
    B4DNY5, F5H7P9, F8W9M3, Q6UXG3, Q8IX38, Q8IX39, Q8TA95
    Related
    ENSP00000321005.3, ENST00000317310.5
    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    43847176..43863639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721721.4 → XP_006721784.1  CMRF35-like molecule 9 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

  2. XM_005257075.4 → XP_005257132.1  CMRF35-like molecule 9 isoform X3

    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

  3. XM_006721722.4 → XP_006721785.1  CMRF35-like molecule 9 isoform X2

    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

  4. XM_005257076.4 → XP_005257133.1  CMRF35-like molecule 9 isoform X5

    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

  5. XM_011524384.4 → XP_011522686.1  CMRF35-like molecule 9 isoform X4

    Conserved Domains (2) summary
    cd05716
    Location:24 → 113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22 → 124
    IG_like; Immunoglobulin like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    44699730..44716193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315209.1 → XP_054171184.1  CMRF35-like molecule 9 isoform X1

  2. XM_054315211.1 → XP_054171186.1  CMRF35-like molecule 9 isoform X3

  3. XM_054315210.1 → XP_054171185.1  CMRF35-like molecule 9 isoform X2

  4. XM_054315213.1 → XP_054171188.1  CMRF35-like molecule 9 isoform X5

  5. XM_054315212.1 → XP_054171187.1  CMRF35-like molecule 9 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXG3.2 GenPept UniProtKB/Swiss-Prot:Q6UXG3

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