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PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 [ Homo sapiens (human) ]

Gene ID: 146850, updated on 3-Apr-2024

Summary

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Official Symbol
PIK3R6provided by HGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 6provided by HGNC
Primary source
HGNC:HGNC:27101
See related
Ensembl:ENSG00000276231 MIM:611462; AllianceGenome:HGNC:27101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
Summary
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Broad expression in spleen (RPKM 2.7), appendix (RPKM 1.8) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17p13.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8802722..8867677, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8708926..8774833, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8706040..8770994, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371530 Neighboring gene uncharacterized LOC124903918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11703 Neighboring gene MPRA-validated peak2720 silencer Neighboring gene major facilitator superfamily domain containing 6 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8730902-8731702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8731703-8732503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8740143-8740949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11712 Neighboring gene uncharacterized LOC107985071 Neighboring gene uncharacterized LOC124903919 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:8788211-8788374 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6. Liu YJ, et al. Eur Rev Med Pharmacol Sci, 2020 Oct. PMID 33155192
  2. p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. Turvey ME, et al. Immunol Cell Biol, 2015 Sep. PMID 25753393
  3. p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity. Shymanets A, et al. J Biol Chem, 2013 Oct 25. PMID 24014027, Free PMC Article
  4. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Jiang K, et al. Nat Immunol, 2000 Nov. PMID 11062502
  5. Function, Regulation and Biological Roles of PI3Kγ Variants. Nürnberg B, et al. Biomolecules, 2019 Aug 30. PMID 31480354, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway.
    Title: PIK3R6 Promotes Angiogenesis in Hepatocellular carcinoma by Activating STAT3 Signaling Pathway.
  2. RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6.
    Title: RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6.
  3. Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity.
    Title: p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.
  4. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways.
    Title: p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.
  5. knockdown of p84 in MDA-MB-231 cells enhanced Akt phosphorylation and lung colonization
    Title: Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis.
  6. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
    Title: GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
  7. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma
    Title: RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma.
  8. ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
    Title: Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells.
  9. p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
    Title: Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34500, DKFZp666P158

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway EXP
Inferred from Experiment
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class IA EXP
Inferred from Experiment
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoinositide 3-kinase regulatory subunit 6
Names
PI3Kgamma adapter protein of 87 kDa
p84 PI3K adapter protein
p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033091.1 RefSeqGene

    Range
    5004..69956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010855.4 → NP_001010855.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 1

    See identical proteins and their annotated locations for NP_001010855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC003695, AC009451, KF573668
    Consensus CDS
    CCDS73985.1
    UniProtKB/Swiss-Prot
    Q5UE93, Q658R3
    Related
    ENSP00000480157.1, ENST00000619866.5
    Conserved Domains (1) summary
    pfam10486
    Location:18 → 751
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  2. NM_001290211.1 → NP_001277140.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091819, BC110301, DB326284
    UniProtKB/TrEMBL
    A4FVB8
    Conserved Domains (1) summary
    pfam10486
    Location:1 → 615
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

  1. NR_110865.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites at internal exons, lacks an internal exon, and contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC009451, AK091819, DB326284
    Related
    ENST00000613555.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8802722..8867677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435450.1 → XP_047291406.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X10

  2. XM_047435452.1 → XP_047291408.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X12

  3. XM_047435444.1 → XP_047291400.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

  4. XM_047435448.1 → XP_047291404.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X7

  5. XM_011523678.3 → XP_011521980.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

    Conserved Domains (1) summary
    pfam10486
    Location:18 → 540
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  6. XM_047435447.1 → XP_047291403.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X6

  7. XM_011523680.3 → XP_011521982.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X9

    Conserved Domains (1) summary
    pfam10486
    Location:18 → 460
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  8. XM_047435451.1 → XP_047291407.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X11

  9. XM_011523677.3 → XP_011521979.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

    Conserved Domains (1) summary
    pfam10486
    Location:18 → 544
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  10. XM_047435446.1 → XP_047291402.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X5

  11. XM_047435443.1 → XP_047291399.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

  12. XM_047435454.1 → XP_047291410.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

  13. XM_011523683.3 → XP_011521985.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

    See identical proteins and their annotated locations for XP_011521985.1

    Conserved Domains (1) summary
    pfam10486
    Location:24 → 465
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  14. XM_047435453.1 → XP_047291409.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

  15. XM_047435457.1 → XP_047291413.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X15

  16. XM_011523686.3 → XP_011521988.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X16

    Conserved Domains (1) summary
    pfam10486
    Location:106 → 256
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  17. XM_047435456.1 → XP_047291412.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X14

  18. XM_047435449.1 → XP_047291405.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X8

  19. XM_047435458.1 → XP_047291414.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X17

RNA

  1. XR_007065269.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8708926..8774833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315186.1 → XP_054171161.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X10

  2. XM_054315188.1 → XP_054171163.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X12

  3. XM_054315180.1 → XP_054171155.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

  4. XM_054315183.1 → XP_054171158.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X7

  5. XM_054315179.1 → XP_054171154.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

  6. XM_054315182.1 → XP_054171157.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X6

  7. XM_054315185.1 → XP_054171160.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X9

  8. XM_054315187.1 → XP_054171162.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X11

  9. XM_054315178.1 → XP_054171153.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

  10. XM_054315181.1 → XP_054171156.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X5

  11. XM_054315177.1 → XP_054171152.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

  12. XM_054315189.1 → XP_054171164.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

  13. XM_054315193.1 → XP_054171168.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X15

  14. XM_054315190.1 → XP_054171165.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

  15. XM_054315191.1 → XP_054171166.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

  16. XM_054315194.1 → XP_054171169.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X16

  17. XM_054315192.1 → XP_054171167.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X14

  18. XM_054315184.1 → XP_054171159.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X8

  19. XM_054315195.1 → XP_054171170.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X17

RNA

  1. XR_008484788.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5UE93.1 GenPept UniProtKB/Swiss-Prot:Q5UE93

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