Gna15 guanine nucleotide binding protein, alpha 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gna15provided by MGI
Official Full Name: guanine nucleotide binding protein, alpha 15provided by MGI
Primary source: MGI:MGI:95770
See related: Ensembl:ENSMUSG00000034792 AllianceGenome:MGI:95770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hg1l; G[a]15; Galpha15
Summary: Enables G protein-coupled receptor binding activity. Involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in brain and retina. Orthologous to human GNA15 (G protein subunit alpha 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 5.4), bladder adult (RPKM 4.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81338147..81360283, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81502313..81524447, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the hydrophobic core buried between helix 8 and TM1-2 of olfactory receptor (mOR-S6) is important for the activation of both G protein alpha 15 (Galpha15).
Title: Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.
The N-terminal hydrophobic core between helix 8 and TM1-2 of mOR-S6 is important for activation of both Galpha15_olf and Galpha15.
Title: The N-terminal acidic residue of the cytosolic helix 8 of an odorant receptor is responsible for different response dynamics via G-protein.
Gna15 maps to mouse chromosome 10 and has similar tissue distribution to mouse s1p(4); transcription of the two genes may be under control of the same enhancer elements
Title: Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Gna15 (e-PCR), detects polymorphism
- UniSTS:496667

NoName (e-PCR)
- UniSTS:224286

PMC85196P1 (e-PCR)
- UniSTS:273466

U37419 (e-PCR)
- UniSTS:163482

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit alpha-15

Names: G-protein subunit alpha-15; g alpha-15; heterotrimeric guanine nucleotide-binding protein 1l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010304.3 → NP_034434.1 guanine nucleotide-binding protein subunit alpha-15

See identical proteins and their annotated locations for NP_034434.1

Status: PROVISIONAL

Source sequence(s)

BC005439

Consensus CDS

CCDS24060.1

UniProtKB/Swiss-Prot

P30678, Q8K1S0

Related

ENSMUSP00000049175.8, ENSMUST00000043709.8

Conserved Domains (1) summary

cd00066
Location:49 → 368

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81338147..81360283 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513234.5 → XP_006513297.1 guanine nucleotide-binding protein subunit alpha-15 isoform X2

Conserved Domains (1) summary

cd00066
Location:49 → 392

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
XM_006513233.5 → XP_006513296.1 guanine nucleotide-binding protein subunit alpha-15 isoform X1

Conserved Domains (1) summary

cd00066
Location:49 → 393

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)