Glra4 glycine receptor, alpha 4 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glra4provided by MGI
Official Full Name: glycine receptor, alpha 4 subunitprovided by MGI
Primary source: MGI:MGI:95750
See related: Ensembl:ENSMUSG00000018595 AllianceGenome:MGI:95750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables extracellularly glycine-gated chloride channel activity. Involved in chloride transmembrane transport and response to amino acid. Is integral component of postsynaptic specialization membrane. Is active in glycinergic synapse. Is expressed in brain. Orthologous to human GLRA4 (glycine receptor alpha 4 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X F1; X 59.1 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (135655107..135680935, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (136754515..136780141, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The distinct developmental regulation of GlyRalpha4 in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation.
Title: Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.
Glycine receptors (GlyRs) of group II cells are dominated by the alpha2 subunit; GlyRs of ON-starburst amacrine cells appear to be dominated by the alpha4 subunit.
Title: Glycinergic input of widefield, displaced amacrine cells of the mouse retina.
The alpha4 subunit was localized in the inner plexiform layer (IPL) in brightly fluorescent puncta, which represent postsynaptically clustered glycine receptors.
Title: Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to amino acid	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycine receptor subunit alpha-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425633.1 → NP_001412562.1 glycine receptor subunit alpha-4 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL671887
NM_001425634.1 → NP_001412563.1 glycine receptor subunit alpha-4 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL671887
NM_001425635.1 → NP_001412564.1 glycine receptor subunit alpha-4 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL671887
NM_001425636.1 → NP_001412565.1 glycine receptor subunit alpha-4 isoform 5

Status: VALIDATED

Source sequence(s)

AL671887
NM_010297.3 → NP_034427.2 glycine receptor subunit alpha-4 isoform 1 precursor

See identical proteins and their annotated locations for NP_034427.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL671887

Consensus CDS

CCDS53195.1

UniProtKB/Swiss-Prot

A2AEA9, Q45V76, Q61603, Q8VHF3

UniProtKB/TrEMBL

Q2TB05

Related

ENSMUSP00000018739.5, ENSMUST00000018739.5

Conserved Domains (1) summary

TIGR00860
Location:9 → 444

LIC; Cation transporter family protein