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ZNF785 zinc finger protein 785 [ Homo sapiens (human) ]

Gene ID: 146540, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF785provided by HGNC
Official Full Name
zinc finger protein 785provided by HGNC
Primary source
HGNC:HGNC:26496
See related
Ensembl:ENSG00000197162 AllianceGenome:HGNC:26496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF688
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 2.1), ovary (RPKM 1.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30578361..30585697, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30965340..30972758, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30591977..30597018, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30552221-30552866 Neighboring gene uncharacterized LOC124903677 Neighboring gene Sharpr-MPRA regulatory region 8694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30564727-30565226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30568583-30569144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10714 Neighboring gene zinc finger protein 764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30580811-30581376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30581377-30581940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7379 Neighboring gene zinc finger protein 688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30596216-30596816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30597418-30598018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7381 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30626940-30627180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30644787-30645738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30645739-30646689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661003-30661520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661521-30662036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7383 Neighboring gene proline rich 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
  2. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  3. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 785 (ZNF785) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 785
Names
Zinc finger protein 688

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152458.7 → NP_689671.2  zinc finger protein 785

    See identical proteins and their annotated locations for NP_689671.2

    Status: VALIDATED

    Source sequence(s)
    AC002310, BC040642, CN401082
    Consensus CDS
    CCDS10685.1
    UniProtKB/Swiss-Prot
    A8K8V0
    UniProtKB/TrEMBL
    B4DQL1
    Related
    ENSP00000378642.2, ENST00000395216.3
    Conserved Domains (3) summary
    smart00349
    Location:29 → 89
    KRAB; krueppel associated box
    COG5048
    Location:143 → 359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174 → 194
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30578361..30585697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022967.3 → XP_016878456.1  zinc finger protein 785 isoform X2

    UniProtKB/Swiss-Prot
    A8K8V0
    UniProtKB/TrEMBL
    B4DQL1
    Related
    ENSP00000420340.1, ENST00000470110.2
    Conserved Domains (3) summary
    smart00349
    Location:29 → 89
    KRAB; krueppel associated box
    COG5048
    Location:143 → 359
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174 → 194
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011545753.3 → XP_011544055.1  zinc finger protein 785 isoform X1

    See identical proteins and their annotated locations for XP_011544055.1

    UniProtKB/TrEMBL
    B4DQL1
    Conserved Domains (3) summary
    smart00349
    Location:29 → 102
    KRAB; krueppel associated box
    COG5048
    Location:156 → 372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30965340..30972758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379677.1 → XP_054235652.1  zinc finger protein 785 isoform X1

  2. XM_054379678.1 → XP_054235653.1  zinc finger protein 785 isoform X2

    UniProtKB/Swiss-Prot
    A8K8V0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8K8V0.1 GenPept UniProtKB/Swiss-Prot:A8K8V0

Gene LinkOut

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