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SPATA8 spermatogenesis associated 8 [ Homo sapiens (human) ]

Gene ID: 145946, updated on 5-Mar-2024

Summary

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Official Symbol
SPATA8provided by HGNC
Official Full Name
spermatogenesis associated 8provided by HGNC
Primary source
HGNC:HGNC:28676
See related
Ensembl:ENSG00000185594 MIM:613948; AllianceGenome:HGNC:28676
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRG8
Expression
Restricted expression toward testis (RPKM 123.5) See more
Orthologs
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Genomic context

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See SPATA8 in Genome Data Viewer
Location:
15q26.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (96783435..96785615)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (94548068..94550248)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (97326665..97328845)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 149, member B2 Neighboring gene SPATA8 antisense RNA 1 (head to head) Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:97339270-97340469 Neighboring gene RN7SK pseudogene 181 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:97420533-97421163 Neighboring gene uncharacterized LOC105371004

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel human testis-specific gene by use of digital differential display. Nie D, et al. J Genet, 2006 Apr. PMID 16809841
  2. Association Study of a Proliferation-inducing Ligand, Spermatogenesis Associated 8, Platelet-derived Growth Factor Receptor-alpha, and POLB Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. Li P, et al. Chin Med J (Engl), 2016 Sep 5. PMID 27569236, Free PMC Article
  3. The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Patel YM, et al. Cancer Epidemiol Biomarkers Prev, 2015 Jan. PMID 25293881, Free PMC Article
  4. GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. Armstrong DL, et al. Genes Immun, 2014 Sep. PMID 24871463, Free PMC Article
  5. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. Anney RJ, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18951430

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
    Title: Association Study of a Proliferation-inducing Ligand, Spermatogenesis Associated 8, Platelet-derived Growth Factor Receptor-alpha, and POLB Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • spermatogenesis-associated protein 8
  • spermatogenesis-related gene 8
  • spermatogenesis-related protein 8
  • testicular secretory protein Li 52

Clone Names

  • MGC44294, MGC102678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_158220.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AY489187, BC033979, DB456215
    Related
    ENST00000649986.1

  2. NR_158221.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC033979, DB456215, HY047940

  3. NR_158222.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AY489187, BC033979, HY034703

  4. NR_158223.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AY489187, BC033979, DB456215, HY024478
    Related
    ENST00000558553.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    96783435..96785615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    94548068..94550248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173499.4: Suppressed sequence

    Description
    NM_173499.4: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RVD6.1 GenPept UniProtKB/Swiss-Prot:Q6RVD6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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