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Ggps1 geranylgeranyl diphosphate synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 14593, updated on 11-Apr-2024

Summary

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Official Symbol
Ggps1provided by MGI
Official Full Name
geranylgeranyl diphosphate synthase 1provided by MGI
Primary source
MGI:MGI:1341724
See related
Ensembl:ENSMUSG00000021302 AllianceGenome:MGI:1341724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810026C22Rik; 9530089B04Rik
Summary
Enables geranyltranstransferase activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to be located in cytoplasm. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.4), CNS E18 (RPKM 5.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A1; 13 5.29 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (14224375..14238319, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (14049790..14063566, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33707 Neighboring gene UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 Neighboring gene zinc finger and BTB domain containing 7B pseudogene Neighboring gene tubulin-specific chaperone E Neighboring gene STARR-seq mESC enhancer starr_33708 Neighboring gene STARR-positive B cell enhancer ABC_E5369 Neighboring gene STARR-positive B cell enhancer ABC_E9866 Neighboring gene STARR-positive B cell enhancer ABC_E32 Neighboring gene AT-rich interaction domain 4B Neighboring gene STARR-seq mESC enhancer starr_33710 Neighboring gene predicted gene, 26129 Neighboring gene zinc finger and SCAN domain containing 5B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury. Li D, et al. Int Immunopharmacol, 2021 Nov. PMID 34530204
  2. Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo. Chong D, et al. J Genet Genomics, 2021 Apr 20. PMID 34049800
  3. Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury. Jin J, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Jun 1. PMID 33729030
  4. Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. Sang YJ, et al. J Mol Cell Biol, 2021 May 7. PMID 33340314, Free PMC Article
  5. Liver governs adipose remodelling via extracellular vesicles in response to lipid overload. Zhao Y, et al. Nat Commun, 2020 Feb 5. PMID 32024826, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.
    Title: CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.
  2. Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
    Title: Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
  3. Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo.
    Title: Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo.
  4. Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.
    Title: Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction.
  5. Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
    Title: Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
  6. The expression level of geranylgeranyl diphosphate synthase (Ggpps), is lower in Non-obstructive azoospermia (NOA) patients than that in obstructive azoospermia (OA) patients. After Ggpps deletion specifically in Sertoli cells (SCs), the mice are infertile and the phenotype of the SC-Ggpps(-/-) mice is similar to the NOA patients, where the blood-testis barrier and the SC-germ cells adhesions are severely destroyed.
    Title: The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis.
  7. The GGPPS deficiency activated lung fibroblast by facilitating transforming growth factor beta1 while antagonizing bone morphogenetic protein 4 signaling. The GGPPS provides protection against pulmonary fibrosis and that the restoration of protein geranylgeranylation may benefit statin-induced lung injury.
    Title: Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling.
  8. Geranylgeranyl pyrophosphate synthase mediated protein geranylgeranylation plays an indispensable role in the ventricular chamber maturation and acts as a stage-specific signal to regulate the establishment of cardiac cytoarchitecture during mid-gestation.
    Title: Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart.
  9. Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation
    Title: Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice.
  10. the specific deletion of Ggps1, using the Collagen 2-CreER(T2) mice, will accelerate the fracture healing process by activating the Bmp2/Smad-dependent Runx2 pathway.
    Title: Knockdown of Ggps1 in chondrocyte expedites fracture healing by accelerating the progression of endochondral ossification in mice.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dimethylallyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables farnesyltranstransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables geranyltranstransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables prenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
geranylgeranyl pyrophosphate synthase
Names
(2E,6E)-farnesyl diphosphate synthase
GGPP synthase
GGPP synthetase
GGPPSase
dimethylallyltranstransferase
farnesyl diphosphate synthase
farnesyltranstransferase
geranylgeranyl pyrophosphate synthetase
geranyltranstransferase
NP_001318048.1
NP_001318105.1
NP_001318106.1
NP_001318107.1
NP_001318109.1
NP_034412.1
XP_006516612.1
XP_011242583.1
XP_017170874.1
XP_017170876.1
XP_017170877.1
XP_030103013.1
XP_030103015.1
XP_036013742.1
XP_036013743.1
XP_036013744.1
XP_036013745.1
XP_036013746.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331119.1 → NP_001318048.1  geranylgeranyl pyrophosphate synthase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AK011980, BC069913, BY273432, CT025604
    Consensus CDS
    CCDS26248.1
    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  2. NM_001331176.1 → NP_001318105.1  geranylgeranyl pyrophosphate synthase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AK011980, BC069913, BF019769, BY273432, CT025604, CX242436
    Consensus CDS
    CCDS26248.1
    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  3. NM_001331177.1 → NP_001318106.1  geranylgeranyl pyrophosphate synthase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AK011980, BC069913, BY273432, CT025604, CX242436
    Consensus CDS
    CCDS26248.1
    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  4. NM_001331178.1 → NP_001318107.1  geranylgeranyl pyrophosphate synthase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AK011980, BC069913, BF019769, BY273432, CT025604
    Consensus CDS
    CCDS26248.1
    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  5. NM_001331180.1 → NP_001318109.1  geranylgeranyl pyrophosphate synthase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC069913, BY273432, CD352882, CT025604
    UniProtKB/Swiss-Prot
    Q9WTN0
    Conserved Domains (1) summary
    pfam00348
    Location:1 → 197
    polyprenyl_synt; Polyprenyl synthetase

  6. NM_010282.3 → NP_034412.1  geranylgeranyl pyrophosphate synthase isoform 1

    See identical proteins and their annotated locations for NP_034412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    BC069913, BY273432, CT025604
    Consensus CDS
    CCDS26248.1
    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Related
    ENSMUSP00000126603.2, ENSMUST00000170957.3
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

RNA

  1. NR_138552.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK011980, BC069913, BY273432, CT025604

  2. NR_138553.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate internal exon and uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK011980, BC069913, BY273432, CT025604

  3. NR_138555.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two alternate internal exons and uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK011980, BY273432, CN537259, CT025604

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    14224375..14238319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315387.3 → XP_017170876.1  geranylgeranyl pyrophosphate synthase isoform X3

    UniProtKB/TrEMBL
    Q9CZZ6
    Related
    ENSMUSP00000152789.2, ENSMUST00000222747.2
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 221
    polyprenyl_synt; Polyprenyl synthetase

  2. XM_036157853.1 → XP_036013746.1  geranylgeranyl pyrophosphate synthase isoform X3

    UniProtKB/TrEMBL
    Q9CZZ6
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 221
    polyprenyl_synt; Polyprenyl synthetase

  3. XM_017315388.3 → XP_017170877.1  geranylgeranyl pyrophosphate synthase isoform X3

    UniProtKB/TrEMBL
    Q9CZZ6
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 221
    polyprenyl_synt; Polyprenyl synthetase

  4. XM_011244281.4 → XP_011242583.1  geranylgeranyl pyrophosphate synthase isoform X3

    See identical proteins and their annotated locations for XP_011242583.1

    UniProtKB/TrEMBL
    Q9CZZ6
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 221
    polyprenyl_synt; Polyprenyl synthetase

  5. XM_006516549.5 → XP_006516612.1  geranylgeranyl pyrophosphate synthase isoform X1

    See identical proteins and their annotated locations for XP_006516612.1

    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  6. XM_030247155.2 → XP_030103015.1  geranylgeranyl pyrophosphate synthase isoform X3

    UniProtKB/TrEMBL
    Q9CZZ6
    Related
    ENSMUSP00000152428.2, ENSMUST00000222164.2
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 221
    polyprenyl_synt; Polyprenyl synthetase

  7. XM_036157852.1 → XP_036013745.1  geranylgeranyl pyrophosphate synthase isoform X3

    UniProtKB/TrEMBL
    Q9CZZ6
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 221
    polyprenyl_synt; Polyprenyl synthetase

  8. XM_017315385.3 → XP_017170874.1  geranylgeranyl pyrophosphate synthase isoform X1

    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  9. XM_036157849.1 → XP_036013742.1  geranylgeranyl pyrophosphate synthase isoform X1

    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  10. XM_036157850.1 → XP_036013743.1  geranylgeranyl pyrophosphate synthase isoform X1

    UniProtKB/Swiss-Prot
    Q9WTN0
    UniProtKB/TrEMBL
    Q3V0T8
    Conserved Domains (1) summary
    pfam00348
    Location:9 → 251
    polyprenyl_synt; Polyprenyl synthetase

  11. XM_036157851.1 → XP_036013744.1  geranylgeranyl pyrophosphate synthase isoform X2

    Conserved Domains (1) summary
    pfam00348
    Location:1 → 197
    polyprenyl_synt; Polyprenyl synthetase

  12. XM_030247153.2 → XP_030103013.1  geranylgeranyl pyrophosphate synthase isoform X2

    Conserved Domains (1) summary
    pfam00348
    Location:1 → 197
    polyprenyl_synt; Polyprenyl synthetase

RNA

  1. XR_003950432.2 RNA Sequence

  2. XR_004937941.1 RNA Sequence

  3. XR_003950431.2 RNA Sequence

  4. XR_001780754.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTN0.1 GenPept UniProtKB/Swiss-Prot:Q9WTN0

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