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Gfpt2 glutamine fructose-6-phosphate transaminase 2 [ Mus musculus (house mouse) ]

Gene ID: 14584, updated on 21-Apr-2024

Summary

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Official Symbol
Gfpt2provided by MGI
Official Full Name
glutamine fructose-6-phosphate transaminase 2provided by MGI
Primary source
MGI:MGI:1338883
See related
Ensembl:ENSMUSG00000020363 AllianceGenome:MGI:1338883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GFAT2
Summary
Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is expressed in craniocervical region bone; naris; and sternum. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GFPT2 (glutamine-fructose-6-phosphate transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 15.4), subcutaneous fat pad adult (RPKM 9.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.2; 11 29.9 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49684981..49729448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49794155..49838620)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 6 Neighboring gene STARR-positive B cell enhancer ABC_E9822 Neighboring gene predicted gene 12192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49538288-49538489 Neighboring gene predicted gene, 36411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49578193-49578302 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49585761-49585914 Neighboring gene STARR-seq mESC enhancer starr_29382 Neighboring gene predicted gene, 36507 Neighboring gene STARR-seq mESC enhancer starr_29384 Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene RasGEF domain family, member 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked β-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages. Al-Mukh H, et al. J Immunol, 2020 Nov 1. PMID 32978282
  2. Cloning and characterization of mouse glutamine:fructose-6-phosphate amidotransferase 2 gene promoter. Yamazaki K, et al. Gene, 2000 Dec 31. PMID 11167021
  3. Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Dai W, et al. Biochim Biophys Acta Mol Basis Dis, 2018 Dec. PMID 30254013, Free PMC Article
  4. Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity. Hu Y, et al. J Biol Chem, 2004 Jul 16. PMID 15133036
  5. Cloning and partial characterization of the mouse glutamine:fructose-6-phosphate amidotransferase (GFAT) gene promoter. Sayeski PP, et al. Nucleic Acids Res, 1997 Apr 1. PMID 9060444, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked beta-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages.
    Title: Lipopolysaccharide Induces GFAT2 Expression to Promote O-Linked β-N-Acetylglucosaminylation and Attenuate Inflammation in Macrophages.
  2. These results support a model wherein high fat diet increases retinal protein O-GlcNAcylation by promoting NR4A1-dependent GFAT2 expression.
    Title: Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression.
  3. mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) is phosphorylated by cAMP-dependent protein kinase, which increases the enzyme activity
    Title: Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity TAS
Traceable Author Statement
more info
 PubMed 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate derivative biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutamine metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Names
D-fructose-6-phosphate amidotransferase 2
GFAT 2
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2
glutamine:fructose-6-phosphate amidotransferase 2
hexosephosphate aminotransferase 2
NP_038557.1
XP_036012229.1
XP_036012230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013529.3 → NP_038557.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

    See identical proteins and their annotated locations for NP_038557.1

    Status: VALIDATED

    Source sequence(s)
    AK132821, BE198515, BM204562, CJ163487, DY247913
    Consensus CDS
    CCDS24622.1
    UniProtKB/Swiss-Prot
    Q5NCL2, Q9Z2Z9
    UniProtKB/TrEMBL
    Q3V0X4
    Related
    ENSMUSP00000020629.5, ENSMUST00000020629.5
    Conserved Domains (4) summary
    PLN02981
    Location:1 → 682
    PLN02981; glucosamine:fructose-6-phosphate aminotransferase
    cd00714
    Location:2 → 285
    GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...
    cd05008
    Location:369 → 494
    SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
    cd05009
    Location:526 → 680
    SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    49684981..49729448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156337.1 → XP_036012230.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X2

    Conserved Domains (1) summary
    PLN02981
    Location:1 → 428
    PLN02981; glucosamine:fructose-6-phosphate aminotransferase

  2. XM_036156336.1 → XP_036012229.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1

    UniProtKB/TrEMBL
    Q3V0X4
    Conserved Domains (1) summary
    PLN02981
    Location:2 → 675
    PLN02981; glucosamine:fructose-6-phosphate aminotransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2Z9.3 GenPept UniProtKB/Swiss-Prot:Q9Z2Z9

Gene LinkOut

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