U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PGPEP1L pyroglutamyl-peptidase I like [ Homo sapiens (human) ]

Gene ID: 145814, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PGPEP1Lprovided by HGNC
Official Full Name
pyroglutamyl-peptidase I likeprovided by HGNC
Primary source
HGNC:HGNC:27080
See related
Ensembl:ENSG00000183571 AllianceGenome:HGNC:27080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable pyroglutamyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (98968229..99007792, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (96732626..96772141, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (99511458..99551021, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 1 receptor Neighboring gene Sharpr-MPRA regulatory region 1759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99340181-99340972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:99342674-99343369 Neighboring gene microRNA 4714 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:99365701-99366259 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:99366260-99366818 Neighboring gene NANOG hESC enhancer GRCh37_chr15:99370256-99370757 Neighboring gene uncharacterized LOC124903561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99427064-99427656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:99427657-99428249 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:99439536-99440735 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:99451095-99451595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6859 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:99558507-99559282 Neighboring gene leukemia-associated non-coding IGF1R activator RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99601057-99601658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:99601659-99602258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:99640383-99641189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6864 Neighboring gene SYNM antisense RNA 1 Neighboring gene synemin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
pyroglutamyl-peptidase 1-like protein
NP_001096082.2
NP_001161374.1
NP_001399058.1
NP_001399059.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102612.2 → NP_001096082.2  pyroglutamyl-peptidase 1-like protein isoform 1

    See identical proteins and their annotated locations for NP_001096082.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the allele encoded by the GRCh38 reference genome and encodes isoform 1.
    Source sequence(s)
    AC036108, AK058162, BC104743, BC104744
    Consensus CDS
    CCDS53977.1
    UniProtKB/Swiss-Prot
    A6NFU8, H0YF86
    UniProtKB/TrEMBL
    A0A1B0GWH3
    Related
    ENSP00000368199.6, ENST00000378919.6
    Conserved Domains (1) summary
    cl00237
    Location:8 → 152
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  2. NM_001167902.2 → NP_001161374.1  pyroglutamyl-peptidase 1-like protein isoform 2

    See identical proteins and their annotated locations for NP_001161374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It also represents the allele encoded by the GRCh38 reference genome. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC036108, AC069029, AK058162, BC104743, BC104744
    Consensus CDS
    CCDS58400.1
    UniProtKB/Swiss-Prot
    A6NFU8
    Related
    ENSP00000437560.1, ENST00000535714.2
    Conserved Domains (1) summary
    cl00237
    Location:5 → 98
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  3. NM_001412129.1 → NP_001399058.1  pyroglutamyl-peptidase 1-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses the same exon combination as variant 2 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (3) has a frameshifted C-terminus compared to isoform 2.
    Source sequence(s)
    CP068263

  4. NM_001412130.1 → NP_001399059.1  pyroglutamyl-peptidase 1-like protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (4) has a frameshifted C-terminus compared to isoform 1.
    Source sequence(s)
    CP068263

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    98968229..99007792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    96732626..96772141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NFU8.4 GenPept UniProtKB/Swiss-Prot:A6NFU8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous