Gdf11 growth differentiation factor 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gdf11provided by MGI
Official Full Name: growth differentiation factor 11provided by MGI
Primary source: MGI:MGI:1338027
See related: Ensembl:ENSMUSG00000025352 AllianceGenome:MGI:1338027
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmp11; BMP-11
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. Mice lacking a functional copy of this gene exhibit impaired anteroposterior patterning and other developmental defects. [provided by RefSeq, Aug 2016]
Expression: Broad expression in CNS E11.5 (RPKM 8.5), whole brain E14.5 (RPKM 5.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.18 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128716393..128727587, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128880524..128891718, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway.
Title: GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway.
Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS/D-GalN acute liver failure.
Title: Silencing of GDF11 suppresses hepatocyte apoptosis to relieve LPS/D-GalN acute liver failure.
Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans.
Title: Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans.
Growth differentiation factor 11 suppresses intrahepatic inflammation via restricting NLRP3 inflammasome activation in LPS-induced liver injury.
Title: Growth differentiation factor 11 suppresses intrahepatic inflammation via restricting NLRP3 inflammasome activation in LPS-induced liver injury.
Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy.
Title: Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy.
MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function.
Title: MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function.
Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
Title: Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways.
Title: GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β-catenin and ALK5/SMAD2/3 pathways.
Neuroprotective effects of TRPV1 by targeting GDF11 in the Mpp+/MPTP-induced Parkinson's disease model.
Title: Neuroprotective effects of TRPV1 by targeting GDF11 in the Mpp+/MPTP-induced Parkinson's disease model.
GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFbetaR1/SMAD-2 pathway.
Title: GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gdf11 (e-PCR), detects polymorphism
- UniSTS:496653

MARC_41381-41054:1084804684:3 (e-PCR)
- UniSTS:471595

RH126796 (e-PCR)
- UniSTS:209741

PMC85795P1 (e-PCR)
- UniSTS:273491

PMC85795P2 (e-PCR)
- UniSTS:273492

RH125938 (e-PCR)
- UniSTS:162650

RH139213 (e-PCR)
- UniSTS:221299

UniSTS:498329 (e-PCR)
- UniSTS:498329

Gdf11 (e-PCR), detects polymorphism
- UniSTS:498329

AI987873 (e-PCR)
- UniSTS:180128

Rdh5 (e-PCR), detects polymorphism
- UniSTS:186537

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of amacrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of amacrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spinal cord anterior/posterior patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type B pancreatic cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: growth/differentiation factor 11

Names: GDF-11; bone morphogenetic protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010272.2 → NP_034402.1 growth/differentiation factor 11 preproprotein

See identical proteins and their annotated locations for NP_034402.1

Status: REVIEWED

Source sequence(s)

AC122380

Consensus CDS

CCDS24296.1

UniProtKB/Swiss-Prot

Q9QX55, Q9R221, Q9Z1W4

Related

ENSMUSP00000026408.7, ENSMUST00000026408.7

Conserved Domains (2) summary

smart00204
Location:311 → 405

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:59 → 283

TGFb_propeptide; TGF-beta propeptide