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Gdap2 ganglioside-induced differentiation-associated-protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14547, updated on 5-Mar-2024

Summary

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Official Symbol
Gdap2provided by MGI
Official Full Name
ganglioside-induced differentiation-associated-protein 2provided by MGI
Primary source
MGI:MGI:1338001
See related
Ensembl:ENSMUSG00000027865 AllianceGenome:MGI:1338001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D3Ertd801e
Summary
Acts upstream of or within response to retinoic acid. Is expressed in several structures, including brain; ganglia; liver; orbito-sphenoid; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 27. Orthologous to human GDAP2 (ganglioside induced differentiation associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 7.1), testis adult (RPKM 6.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 43.49 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100069843..100117909)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100162381..100206989)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 17 Neighboring gene ribosomal protein L36, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_08490 Neighboring gene STARR-seq mESC enhancer starr_08491 Neighboring gene STARR-positive B cell enhancer ABC_E6088 Neighboring gene WD repeat domain 3 Neighboring gene STARR-seq mESC enhancer starr_08494 Neighboring gene predicted gene, 25802 Neighboring gene STARR-seq mESC enhancer starr_08495 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. Liu H, et al. J Neurochem, 1999 May. PMID 10217254
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to retinoic acid IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ganglioside-induced differentiation-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410111.1 → NP_001397040.1  ganglioside-induced differentiation-associated protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742
    UniProtKB/Swiss-Prot
    O88742, Q8C468, Q9DBL2

  2. NM_001410112.1 → NP_001397041.1  ganglioside-induced differentiation-associated protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742

  3. NM_010269.4 → NP_034399.1  ganglioside-induced differentiation-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_034399.1

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742
    Consensus CDS
    CCDS17675.1
    UniProtKB/Swiss-Prot
    O88742, Q8C468, Q9DBL2
    Related
    ENSMUSP00000029459.4, ENSMUST00000029459.10
    Conserved Domains (2) summary
    cd02905
    Location:54 → 193
    Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    pfam13716
    Location:350 → 481
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RNA

  1. NR_104341.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742

  2. NR_176946.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742

  3. NR_176948.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742

  4. NR_176949.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742

  5. NR_176950.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102209, AL606742

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    100069843..100117909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBL2.1 GenPept UniProtKB/Swiss-Prot:Q9DBL2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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