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Gda guanine deaminase [ Mus musculus (house mouse) ]

Gene ID: 14544, updated on 11-Apr-2024

Summary

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Official Symbol
Gdaprovided by MGI
Official Full Name
guanine deaminaseprovided by MGI
Primary source
MGI:MGI:95678
See related
Ensembl:ENSMUSG00000058624 AllianceGenome:MGI:95678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAH
Summary
Enables guanine deaminase activity. Involved in allantoin metabolic process and purine-containing compound catabolic process. Located in cytosol. Is expressed in several structures, including adrenal gland; brain; and peripheral nervous system ganglion. Orthologous to human GDA (guanine deaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 22.6), cortex adult (RPKM 19.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Gda in Genome Data Viewer
Location:
19 B; 19 14.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (21368671..21450025, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (21391307..21472661, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1562 Neighboring gene STARR-seq mESC enhancer starr_45720 Neighboring gene predicted gene, 45918 Neighboring gene STARR-seq mESC enhancer starr_45722 Neighboring gene VISTA enhancer mm269 Neighboring gene predicted gene, 57661 Neighboring gene zinc finger, AN1-type domain 5 Neighboring gene STARR-seq mESC enhancer starr_45723 Neighboring gene STARR-seq mESC enhancer starr_45724 Neighboring gene STARR-seq mESC enhancer starr_45725 Neighboring gene STARR-seq mESC enhancer starr_45726 Neighboring gene chromosome 19 C9orf57 homolog Neighboring gene predicted gene, 38486

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cDNA sequence of five mouse guanine deaminase (Gda) alleles and mapping to mouse chromosome 19. Giese RD, et al. Genome, 2002 Apr. PMID 11962625
  2. The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine. Mohamedali KA, et al. J Biol Chem, 1993 Nov 5. PMID 8226898
  3. Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. Yuan G, et al. J Biol Chem, 1999 Mar 19. PMID 10075721
  4. Enzymes of purine salvage and catabolism in the mouse preimplantation embryo measured by high performance liquid chromatography. Alexiou M, et al. J Reprod Fertil, 1994 May. PMID 8064675
  5. Proteomics analysis of immuno-precipitated synaptic protein complexes. Klemmer P, et al. J Proteomics, 2009 Feb 15. PMID 19022416

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dGMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in deoxyguanosine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in guanine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in guanine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanine deaminase
Names
guanase
guanine aminase
guanine aminohydrolase
NP_034396.1
XP_006526743.1
XP_017173553.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010266.2 → NP_034396.1  guanine deaminase

    See identical proteins and their annotated locations for NP_034396.1

    Status: VALIDATED

    Source sequence(s)
    AC103947, AK041056, BY250819
    Consensus CDS
    CCDS29698.1
    UniProtKB/Swiss-Prot
    Q9R111
    UniProtKB/TrEMBL
    Q3U0C4, Q548F2, Q71RH5, Q71RH6
    Related
    ENSMUSP00000084882.4, ENSMUST00000087600.10
    Conserved Domains (1) summary
    cd01303
    Location:13 → 444
    GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    21368671..21450025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526680.2 → XP_006526743.1  guanine deaminase isoform X1

    UniProtKB/TrEMBL
    A0A494B982
    Related
    ENSMUSP00000157532.2, ENSMUST00000237823.2
    Conserved Domains (1) summary
    cd01303
    Location:2 → 402
    GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...

  2. XM_017318064.3 → XP_017173553.1  guanine deaminase isoform X2

    UniProtKB/TrEMBL
    A0A494B982, D3YU09
    Related
    ENSMUSP00000112758.2, ENSMUST00000121725.8
    Conserved Domains (1) summary
    cl00281
    Location:1 → 370
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R111.1 GenPept UniProtKB/Swiss-Prot:Q9R111

Gene LinkOut

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