U.S. flag

An official website of the United States government

GSC goosecoid homeobox [ Homo sapiens (human) ]

Gene ID: 145258, updated on 10-Dec-2024

Summary

Official Symbol
GSCprovided by HGNC
Official Full Name
goosecoid homeoboxprovided by HGNC
Primary source
HGNC:HGNC:4612
See related
Ensembl:ENSG00000133937 MIM:138890; AllianceGenome:HGNC:4612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSC1; SAMS
Summary
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 1.7), brain (RPKM 0.2) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GSC in Genome Data Viewer
Location:
14q32.13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94768223..94770113, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88998287..89000177, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95234560..95236450, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 59 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95147830-95148378 Neighboring gene ribosomal protein SA pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95234013-95234551 Neighboring gene GSC divergent transcript Neighboring gene ribosomal protein L15 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin  
is_active_in nucleus  
part_of transcription regulator complex  

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034111.1 RefSeqGene

    Range
    5050..6940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173849.3NP_776248.1  homeobox protein goosecoid

    See identical proteins and their annotated locations for NP_776248.1

    Status: REVIEWED

    Source sequence(s)
    AY177407
    Consensus CDS
    CCDS9930.1
    UniProtKB/Swiss-Prot
    P56915, Q86YR1
    Related
    ENSP00000238558.3, ENST00000238558.5
    Conserved Domains (1) summary
    pfam00046
    Location:163216
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    94768223..94770113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    88998287..89000177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Loading
External link. Please review our privacy policy.