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Gas7 growth arrest specific 7 [ Mus musculus (house mouse) ]

Gene ID: 14457, updated on 11-Apr-2024

Summary

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Official Symbol
Gas7provided by MGI
Official Full Name
growth arrest specific 7provided by MGI
Primary source
MGI:MGI:1202388
See related
Ensembl:ENSMUSG00000033066 AllianceGenome:MGI:1202388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gas7-cb; B230343A10Rik
Summary
Enables actin filament binding activity. Acts upstream of or within actin filament organization; neuron projection morphogenesis; and regulation of cell shape. Located in actin filament and ruffle. Is expressed in forebrain. Orthologous to human GAS7 (growth arrest specific 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 37.9), cerebellum adult (RPKM 29.9) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 41.13 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67344083..67579818)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67453257..67688992)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 13, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29800 Neighboring gene predicted gene, 40029 Neighboring gene predicted gene, 31459 Neighboring gene STARR-seq mESC enhancer starr_29801 Neighboring gene STARR-positive B cell enhancer ABC_E10680 Neighboring gene STARR-positive B cell enhancer ABC_E1827 Neighboring gene predicted gene 12301 Neighboring gene glucagon-like peptide 2 receptor Neighboring gene recoverin Neighboring gene STARR-seq mESC enhancer starr_29802 Neighboring gene GSG1-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7. Hanawa-Suetsugu K, et al. Nat Commun, 2019 Oct 18. PMID 31628328, Free PMC Article
  2. Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization. Xu Q, et al. Immunol Res, 2017 Oct. PMID 28895026
  3. Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7. Uchida T, et al. J Mol Biol, 2009 Sep 4. PMID 19580814
  4. Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells. Chao CC, et al. J Neurosci Res, 2003 Oct 15. PMID 14515354
  5. The Gas7 gene encodes two protein isoforms differentially expressed within the brain. Lazakovitch EM, et al. Genomics, 1999 Nov 1. PMID 10552931

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Growth Arrest-Specific 7 (GAS7) plays a critical role in phagocytic cup formation in macrophages.
    Title: Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.
  2. Gas7-related M1 gene expression in alveolar macrophage was not dependent on NF-kappaB and STAT1 pathway
    Title: Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization.
  3. These results demonstrate GAS7 as a susceptibility gene for schizophrenia.
    Title: Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis.
  4. Forced expression of Gas7a or Gas7b isoform in mouse neuroblastoma Neuro2A cells, which express a defective Gas7 gene, rendered the cells proapoptotic and vulnerable to cisplatin-induced apoptosis.
    Title: Knockdown of growth-arrest-specific gene 7b (gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: Implications for preventing apoptosis of neurons.
  5. Gas7 works through its interaction with N-WASP during neuronal maturation/ differentiation
    Title: Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.
  6. Gas7b has a role in microtubular maintenance
    Title: A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.
  7. These results suggest that Gas7 enhances microtubule polymerization by stabilizing sheet intermediates and is a useful tool for analyzing microtubule transformation.
    Title: Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7.
  8. Hoxa7 and Hoxa9 contribute to hematopoietic progenitor homeostasis but are not necessary for MLL-GAS7-mediated leukemogenesis
    Title: Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.
  9. Our data reveal that Gas7 might play a role in cellular migration and cell protection in the ES cells of mouse embryo.
    Title: Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice.
  10. The ability of gas7 to potentiate neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in the injured or diseased brain, such as following stroke.
    Title: The gas7 protein potentiates NGF-mediated differentiation of PC12 cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
growth arrest-specific protein 7
Names
growth arrest-specific 7 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109657.4 → NP_001103127.1  growth arrest-specific protein 7 isoform b

    See identical proteins and their annotated locations for NP_001103127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AL596255, AL646097, AL662883
    Consensus CDS
    CCDS48821.1
    UniProtKB/Swiss-Prot
    Q60780, Q9QY25, Q9QY26, Q9QY34
    UniProtKB/TrEMBL
    Q3U432
    Related
    ENSMUSP00000104320.3, ENSMUST00000108680.3
    Conserved Domains (2) summary
    cd07649
    Location:154 → 386
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:49 → 141
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  2. NM_001277079.1 → NP_001264008.1  growth arrest-specific protein 7 isoform c

    See identical proteins and their annotated locations for NP_001264008.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK152149, AL646097, BU053145, CJ147966, CV562268
    Consensus CDS
    CCDS70210.1
    UniProtKB/Swiss-Prot
    Q60780, Q9QY25, Q9QY26, Q9QY34
    UniProtKB/TrEMBL
    B1ATI9
    Related
    ENSMUSP00001091663.1, ENSMUST00020183803.1
    Conserved Domains (2) summary
    cd07649
    Location:150 → 382
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:45 → 137
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  3. NM_001277080.1 → NP_001264009.1  growth arrest-specific protein 7 isoform d

    See identical proteins and their annotated locations for NP_001264009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK152149, AL646097, CJ146254, CJ147966, CV562268
    UniProtKB/TrEMBL
    Q6A075
    Conserved Domains (2) summary
    cd07649
    Location:91 → 323
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:33 → 78
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  4. NM_001402818.1 → NP_001389747.1  growth arrest-specific protein 7 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL596255, AL646097, AL662883
    UniProtKB/TrEMBL
    F6QB26
    Related
    ENSMUSP00000104321.3, ENSMUST00000108681.9

  5. NM_001402819.1 → NP_001389748.1  growth arrest-specific protein 7 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL596255, AL646097, AL662883

  6. NM_001402821.1 → NP_001389750.1  growth arrest-specific protein 7 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL596255, AL646097, AL662883
    UniProtKB/TrEMBL
    B1ATI9

  7. NM_001402823.1 → NP_001389752.1  growth arrest-specific protein 7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL596255, AL646097, AL662883

  8. NM_001402824.1 → NP_001389753.1  growth arrest-specific protein 7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL596255, AL646097, AL662883

  9. NM_001402825.1 → NP_001389754.1  growth arrest-specific protein 7 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL646097

  10. NM_008088.5 → NP_032114.2  growth arrest-specific protein 7 isoform a

    See identical proteins and their annotated locations for NP_032114.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK076926, AK152149, AL596255, AL646097, CV562268
    UniProtKB/Swiss-Prot
    Q60780, Q9QY25, Q9QY26, Q9QY34
    UniProtKB/TrEMBL
    Q0VBR8
    Conserved Domains (2) summary
    cd07649
    Location:159 → 391
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:54 → 146
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67344083..67579818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245564.1 → XP_030101424.1  growth arrest-specific protein 7 isoform X5

    UniProtKB/TrEMBL
    Q6A075
    Conserved Domains (2) summary
    cd07649
    Location:91 → 323
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:33 → 78
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  2. XM_017314262.1 → XP_017169751.1  growth arrest-specific protein 7 isoform X3

    UniProtKB/Swiss-Prot
    Q60780, Q9QY25, Q9QY26, Q9QY34
    UniProtKB/TrEMBL
    B1ATI9
    Related
    ENSMUSP00000038420.6, ENSMUST00000041611.12
    Conserved Domains (2) summary
    cd07649
    Location:150 → 382
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:45 → 137
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  3. XM_006532209.1 → XP_006532272.1  growth arrest-specific protein 7 isoform X5

    See identical proteins and their annotated locations for XP_006532272.1

    UniProtKB/TrEMBL
    Q6A075
    Conserved Domains (2) summary
    cd07649
    Location:91 → 323
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:33 → 78
    WW_FCH_linker; Unstructured linker region between on GAS7 protein

  4. XM_006532208.4 → XP_006532271.1  growth arrest-specific protein 7 isoform X4

    UniProtKB/TrEMBL
    Q3U8N2
    Conserved Domains (2) summary
    cd07649
    Location:110 → 342
    F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
    pfam16623
    Location:14 → 97
    WW_FCH_linker; Unstructured linker region between on GAS7 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60780.1 GenPept UniProtKB/Swiss-Prot:Q60780

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