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Gas2 growth arrest specific 2 [ Mus musculus (house mouse) ]

Gene ID: 14453, updated on 21-Apr-2024

Summary

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Official Symbol
Gas2provided by MGI
Official Full Name
growth arrest specific 2provided by MGI
Primary source
MGI:MGI:95657
See related
Ensembl:ENSMUSG00000030498 AllianceGenome:MGI:95657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gas-2
Summary
Predicted to enable actin filament binding activity and cytoskeletal anchor activity. Acts upstream of or within several processes, including ovarian follicle development; ovulation; and regulation of Notch signaling pathway. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be active in actin filament. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; lens; and limb. Orthologous to human GAS2 (growth arrest specific 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 19.6), kidney adult (RPKM 14.5) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B4; 7 32.87 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (51511560..51644753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (51861791..51995005)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene VISTA enhancer mm683 Neighboring gene predicted gene, 33290 Neighboring gene Fanconi anemia, complementation group F Neighboring gene STARR-seq mESC enhancer starr_18929 Neighboring gene STARR-seq mESC enhancer starr_18930 Neighboring gene STARR-positive B cell enhancer mm9_chr7:59261106-59261406 Neighboring gene small VCP/p97-interacting protein Neighboring gene coiled-coil domain containing 179

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of growth arrest-specific (Gas) genes in murine keratinocytes: Gas2 is specifically regulated. Manzow S, et al. Exp Cell Res, 1996 Apr 10. PMID 8612686
  2. Phosphorylation of the growth arrest-specific protein Gas2 is coupled to actin rearrangements during Go-->G1 transition in NIH 3T3 cells. Brancolini C, et al. J Cell Biol, 1994 Mar. PMID 8120096, Free PMC Article
  3. Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. Brancolini C, et al. EMBO J, 1995 Nov 1. PMID 7489707, Free PMC Article
  4. gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb. Lee KK, et al. Dev Biol, 1999 Mar 1. PMID 10049561
  5. A TaqI RFLP at the gas-2 locus. Colombo MP, et al. Nucleic Acids Res, 1989 Sep 25. PMID 2571977, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
    Title: Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
  2. GAS2 is a critical and novel regulator of tissue remodeling in the ovary during oocyte cyst breakdown and folliculogenesis
    Title: Growth Arrest Specific 2 (GAS2) is a Critical Mediator of Germ Cell Cyst Breakdown and Folliculogenesis in Mice.
  3. these findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24/ MEFs by suppressing GAS2 in vitro.
    Title: miR‑342‑5p promotes Zmpste24‑deficient mouse embryonic fibroblasts proliferation by suppressing GAS2.
  4. Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin
    Title: The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antral ovarian follicle growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within initiation of primordial ovarian follicle growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
growth arrest-specific protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330607.2 → NP_001317536.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, and 4-11 all encode the same isoform (1).
    Source sequence(s)
    AC113312, AC122017, AC158345
    Consensus CDS
    CCDS21310.1
    UniProtKB/Swiss-Prot
    P11862
    Related
    ENSMUSP00000053514.7, ENSMUST00000051912.13
    Conserved Domains (2) summary
    smart00243
    Location:201 → 274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  2. NM_001330608.2 → NP_001317537.1  growth arrest-specific protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/TrEMBL
    Q9D699
    Conserved Domains (2) summary
    smart00243
    Location:143 → 216
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:1 → 100
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  3. NM_001412458.1 → NP_001399387.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862

  4. NM_001412459.1 → NP_001399388.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862

  5. NM_001412460.1 → NP_001399389.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862

  6. NM_001412461.1 → NP_001399390.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862

  7. NM_001412462.1 → NP_001399391.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862

  8. NM_001412463.1 → NP_001399392.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862

  9. NM_001412464.1 → NP_001399393.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862
    Related
    ENSMUSP00000146537.2, ENSMUST00000208711.2

  10. NM_001412465.1 → NP_001399394.1  growth arrest-specific protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345
    UniProtKB/Swiss-Prot
    P11862

  11. NM_001412466.1 → NP_001399395.1  growth arrest-specific protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  12. NM_001412467.1 → NP_001399396.1  growth arrest-specific protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  13. NM_001412468.1 → NP_001399397.1  growth arrest-specific protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  14. NM_001412469.1 → NP_001399398.1  growth arrest-specific protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  15. NM_008087.4 → NP_032113.1  growth arrest-specific protein 2 isoform 1

    See identical proteins and their annotated locations for NP_032113.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 4-11 all encode the same isoform (1).
    Source sequence(s)
    AC113312, AC122017, AC158345
    Consensus CDS
    CCDS21310.1
    UniProtKB/Swiss-Prot
    P11862
    Related
    ENSMUSP00000103217.3, ENSMUST00000107591.9
    Conserved Domains (2) summary
    smart00243
    Location:201 → 274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RNA

  1. NR_178198.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  2. NR_178199.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  3. NR_178200.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  4. NR_178201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

  5. NR_178202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113312, AC122017, AC158345

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    51511560..51644753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242137.2 → XP_030097997.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/Swiss-Prot
    P11862
    Conserved Domains (2) summary
    smart00243
    Location:201 → 274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  2. XM_006540619.5 → XP_006540682.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540682.1

    Conserved Domains (2) summary
    smart00243
    Location:228 → 301
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:30 → 191
    CH_SF; calponin homology (CH) domain superfamily

  3. XM_036152682.1 → XP_036008575.1  growth arrest-specific protein 2 isoform X3

    Conserved Domains (2) summary
    cl00030
    Location:30 → 191
    CH_SF; calponin homology (CH) domain superfamily
    cl02524
    Location:230 → 270
    GAS2; Growth-Arrest-Specific Protein 2 Domain

  4. XM_030242140.2 → XP_030098000.1  growth arrest-specific protein 2 isoform X2

    UniProtKB/Swiss-Prot
    P11862
    Conserved Domains (2) summary
    smart00243
    Location:201 → 274
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cd00014
    Location:36 → 158
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

  5. XM_036152681.1 → XP_036008574.1  growth arrest-specific protein 2 isoform X1

    Conserved Domains (2) summary
    smart00243
    Location:228 → 301
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:30 → 191
    CH_SF; calponin homology (CH) domain superfamily

  6. XM_006540623.4 → XP_006540686.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540686.1

    Conserved Domains (2) summary
    smart00243
    Location:228 → 301
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:30 → 191
    CH_SF; calponin homology (CH) domain superfamily

  7. XM_006540618.3 → XP_006540681.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540681.1

    Conserved Domains (2) summary
    smart00243
    Location:228 → 301
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:30 → 191
    CH_SF; calponin homology (CH) domain superfamily

  8. XM_006540622.3 → XP_006540685.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540685.1

    Conserved Domains (2) summary
    smart00243
    Location:228 → 301
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:30 → 191
    CH_SF; calponin homology (CH) domain superfamily

  9. XM_006540621.5 → XP_006540684.1  growth arrest-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540684.1

    Conserved Domains (2) summary
    smart00243
    Location:228 → 301
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    cl00030
    Location:30 → 191
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11862.1 GenPept UniProtKB/Swiss-Prot:P11862

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