U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TSPAN19 tetraspanin 19 [ Homo sapiens (human) ]

Gene ID: 144448, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
TSPAN19provided by HGNC
Official Full Name
tetraspanin 19provided by HGNC
Primary source
HGNC:HGNC:31886
See related
Ensembl:ENSG00000231738 AllianceGenome:HGNC:31886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.0), lung (RPKM 1.0) and 6 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TSPAN19 in Genome Data Viewer
Location:
12q21.31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (85014317..85036277, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (84993703..85015667, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (85408096..85430055, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 15 Neighboring gene uncharacterized LOC124903121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:85305148-85305696 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:85306245-85306792 Neighboring gene uncharacterized LOC102724680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:85306793-85307339 Neighboring gene NANOG hESC enhancer GRCh37_chr12:85397904-85398436 Neighboring gene Sharpr-MPRA regulatory region 14945 Neighboring gene leucine rich repeats and IQ motif containing 1 Neighboring gene Sharpr-MPRA regulatory region 79 Neighboring gene ALX homeobox 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ44351

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tetraspanin-19
Names
putative tetraspanin-19
tspan-19

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100917.2 → NP_001094387.1  tetraspanin-19

    See identical proteins and their annotated locations for NP_001094387.1

    Status: VALIDATED

    Source sequence(s)
    AK126325, BX116902, CB852874
    Consensus CDS
    CCDS44949.1
    UniProtKB/Swiss-Prot
    P0C672
    Related
    ENSP00000433816.2, ENST00000532498.7
    Conserved Domains (2) summary
    cd03160
    Location:107 → 212
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9 → 240
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    85014317..85036277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018863.3 → XP_016874352.1  tetraspanin-19 isoform X2

    Conserved Domains (2) summary
    cl02781
    Location:107 → 210
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:9 → 238
    Tetraspannin; Tetraspanin family

  2. XM_005268669.5 → XP_005268726.1  tetraspanin-19 isoform X1

    See identical proteins and their annotated locations for XP_005268726.1

    UniProtKB/Swiss-Prot
    P0C672
    Conserved Domains (2) summary
    cd03160
    Location:107 → 212
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9 → 240
    Tetraspannin; Tetraspanin family

  3. XM_017018862.2 → XP_016874351.1  tetraspanin-19 isoform X1

    UniProtKB/Swiss-Prot
    P0C672
    Conserved Domains (2) summary
    cd03160
    Location:107 → 212
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9 → 240
    Tetraspannin; Tetraspanin family

  4. XM_047428375.1 → XP_047284331.1  tetraspanin-19 isoform X3

  5. XM_017018864.2 → XP_016874353.1  tetraspanin-19 isoform X3

    Conserved Domains (3) summary
    cl02781
    Location:107 → 198
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:9 → 189
    Tetraspannin; Tetraspanin family
    cl00473
    Location:20 → 109
    BI-1-like; BAX inhibitor (BI)-1/YccA-like protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    84993703..85015667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371181.1 → XP_054227156.1  tetraspanin-19 isoform X2

  2. XM_054371179.1 → XP_054227154.1  tetraspanin-19 isoform X1

    UniProtKB/Swiss-Prot
    P0C672

  3. XM_054371180.1 → XP_054227155.1  tetraspanin-19 isoform X1

    UniProtKB/Swiss-Prot
    P0C672

  4. XM_054371182.1 → XP_054227157.1  tetraspanin-19 isoform X3

  5. XM_054371183.1 → XP_054227158.1  tetraspanin-19 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C672.1 GenPept UniProtKB/Swiss-Prot:P0C672

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous