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Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 14426, updated on 5-Mar-2024

Summary

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Official Symbol
Galnt4provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 4provided by MGI
Primary source
MGI:MGI:894692
See related
Ensembl:ENSMUSG00000090035 AllianceGenome:MGI:894692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system and extraembryonic component. Orthologous to several human genes including POC1B-GALNT4 (POC1B-GALNT4 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
10 51.06 cM; 10 C3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (98943997..98949109)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99108135..99113247)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:98376846-98377147 Neighboring gene predicted gene, 53607 Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 Neighboring gene STARR-positive B cell enhancer ABC_E3912 Neighboring gene STARR-seq mESC enhancer starr_27702 Neighboring gene STARR-seq mESC enhancer starr_27703 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98589429-98589538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98590442-98590625 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98594927-98595144 Neighboring gene POC1 centriolar protein B Neighboring gene STARR-seq mESC enhancer starr_27706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98634758-98634867 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:98644928-98645081 Neighboring gene STARR-positive B cell enhancer ABC_E6916 Neighboring gene predicted gene 16239 Neighboring gene STARR-positive B cell enhancer mm9_chr10:98667182-98667482 Neighboring gene STARR-seq mESC enhancer starr_27708 Neighboring gene predicted gene, 34574

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis. Ye Z, et al. J Mol Cell Cardiol, 2022 Apr. PMID 34974060
  2. N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization. Zhou J, et al. Hepatology, 2022 Jun. PMID 34662438
  3. Isoform-specific regulation of osteogenic factors by polypeptide N-Acetylgalactosaminyltransferases 1 and 4. Tang J, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27965094
  4. cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Hagen FK, et al. J Biol Chem, 1997 May 23. PMID 9153242
  5. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization.
    Title: N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization.
  2. GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis.
    Title: GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis.
  3. the ppGalNAc-T4 was highly expressed in MC3T3-E1 cells during osteogenesis for the first time; ppGalNAc-T1 and -T4 affected the expression of different osteogenic factors, suggesting distinct roles ppGalNAc-T isoforms play in regulating osteogenesis in vitro
    Title: Isoform-specific regulation of osteogenic factors by polypeptide N-Acetylgalactosaminyltransferases 1 and 4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 4
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4
galNAc-T4
polypeptide GalNAc transferase 4
pp-GaNTase 4
ppGaNTase-T4
protein-UDP acetylgalactosaminyltransferase 4
NP_056552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015737.4 → NP_056552.1  polypeptide N-acetylgalactosaminyltransferase 4

    See identical proteins and their annotated locations for NP_056552.1

    Status: VALIDATED

    Source sequence(s)
    AK148036, AV080565, BP761617, BQ179479, CJ093518
    Consensus CDS
    CCDS48679.1
    UniProtKB/Swiss-Prot
    O08832, Q3U681
    Related
    ENSMUSP00000125315.3, ENSMUST00000161240.4
    Conserved Domains (4) summary
    cd02510
    Location:138 → 432
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:133 → 430
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:446 → 576
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:446 → 574
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    98943997..98949109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08832.1 GenPept UniProtKB/Swiss-Prot:O08832

Gene LinkOut

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