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G6pd2 glucose-6-phosphate dehydrogenase 2 [ Mus musculus (house mouse) ]

Gene ID: 14380, updated on 11-Apr-2024

Summary

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Official Symbol
G6pd2provided by MGI
Official Full Name
glucose-6-phosphate dehydrogenase 2provided by MGI
Primary source
MGI:MGI:105977
See related
Ensembl:ENSMUSG00000089992 AllianceGenome:MGI:105977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpd2; Gpd-2; G6pdx-ps1
Summary
Predicted to enable several functions, including glucose binding activity; glucose-6-phosphate dehydrogenase activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of protein glutathionylation; and pentose-phosphate shunt, oxidative branch. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic side of plasma membrane; and cytosol. Is expressed in genitourinary system; nervous system; and nose. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See G6pd2 in Genome Data Viewer
Location:
5 C3.1; 5 31.99 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (61966186..61967820)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (61808843..61810477)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13166 Neighboring gene predicted gene, 40308 Neighboring gene SEC63-like pseudogene Neighboring gene predicted gene, 22273

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus). Ruddle FH, et al. Genetics, 1968 Apr. PMID 5693479, Free PMC Article
  2. Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse. Hendriksen PJ, et al. Genomics, 1997 May 1. PMID 9169132
  3. The evolutionary fate of recently duplicated retrogenes in mice. Gayral P, et al. J Evol Biol, 2007 Mar. PMID 17305828
  4. Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion. Nagle DL, et al. Hum Mol Genet, 1995 Nov. PMID 8589683
  5. Genetic mapping of three GABAA receptor-subunit genes in the mouse. Danciger M, et al. Genomics, 1993 May. PMID 8390964

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables glucose binding ISO
Inferred from Sequence Orthology
more info
  
enables glucose-6-phosphate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose-6-phosphate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH regeneration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein glutathionylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, oxidative branch ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in ribose phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-6-phosphate 1-dehydrogenase 2
Names
G6PD
glucose-6-phosphate dehydrogenase X-linked, pseudogene 1
NP_062341.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019468.2 → NP_062341.2  glucose-6-phosphate 1-dehydrogenase 2

    See identical proteins and their annotated locations for NP_062341.2

    Status: VALIDATED

    Source sequence(s)
    AC114918, BC137684
    Consensus CDS
    CCDS19297.1
    UniProtKB/Swiss-Prot
    P97324, Q0VB18
    UniProtKB/TrEMBL
    G3UWD6
    Related
    ENSMUSP00000131163.2, ENSMUST00000053876.5
    Conserved Domains (3) summary
    TIGR00871
    Location:30 → 506
    zwf; glucose-6-phosphate 1-dehydrogenase
    pfam00479
    Location:35 → 209
    G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
    pfam02781
    Location:212 → 503
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    61966186..61967820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97324.3 GenPept UniProtKB/Swiss-Prot:P97324

Gene LinkOut

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