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Fut9 fucosyltransferase 9 [ Mus musculus (house mouse) ]

Gene ID: 14348, updated on 5-Mar-2024

Summary

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Official Symbol
Fut9provided by MGI
Official Full Name
fucosyltransferase 9provided by MGI
Primary source
MGI:MGI:1330859
See related
Ensembl:ENSMUSG00000055373 AllianceGenome:MGI:1330859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFUT9; mFuc-TIX
Summary
Enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in cellular polysaccharide biosynthetic process and fucosylation. Acts upstream of or within protein glycosylation. Located in Golgi apparatus. Is expressed in brain; central nervous system; and telencephalon. Orthologous to human FUT9 (fucosyltransferase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 6.6), cerebellum adult (RPKM 5.7) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 10.59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (25609333..25800003, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (25609333..25800003, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11893 Neighboring gene predicted gene, 24977 Neighboring gene STARR-seq mESC enhancer starr_09788 Neighboring gene STARR-seq mESC enhancer starr_09789 Neighboring gene STARR-seq mESC enhancer starr_09791 Neighboring gene STARR-seq mESC enhancer starr_09792 Neighboring gene predicted gene, 24042 Neighboring gene predicted gene, 42263

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-Scale Identification of N-Glycan Glycoproteins Carrying Lewis x and Site-Specific N-Glycan Alterations in Fut9 Knockout Mice. Noro E, et al. J Proteome Res, 2015 Sep 4. PMID 26244810
  2. Mice lacking α1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens. Kashiwazaki H, et al. Pathol Int, 2014 May. PMID 24888773, Free PMC Article
  3. Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells. Blanas A, et al. Glycobiology, 2019 Feb 1. PMID 30476078, Free PMC Article
  4. Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. Kaneko M, et al. FEBS Lett, 1999 Jun 11. PMID 10386598
  5. Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney. Kudo T, et al. J Biol Chem, 1998 Oct 9. PMID 9756916

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It sought to transcriptionally activate the Fut9 gene in the well-known murine colorectal cancer cell line, MC38, which lacks expression of the FUT4 and FUT9 enzymes.
    Title: Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells.
  2. N-linked glycan mass spectrometry profile of wild-type mouse kidney glycoproteins revealed the presence of abundant terminal fucoses, which were lost following knockout of the Fut9 gene
    Title: Large-Scale Identification of N-Glycan Glycoproteins Carrying Lewis x and Site-Specific N-Glycan Alterations in Fut9 Knockout Mice.
  3. Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens.
    Title: Mice lacking α1,3-fucosyltransferase 9 exhibit modulation of in vivo immune responses against pathogens.
  4. We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis.
    Title: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.
  5. FUT9 plays a significant role during human, but not mouse, E-selectin-mediated cell adhesion.
    Title: Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.
  6. Mice lacking fut9 demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors.
    Title: Mice lacking alpha1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors.
  7. Alpha1,3-fucosyltransferase IX (Fut9)regulates expression of the Lewis X (Lex) carbohydrate structure in brain development
    Title: Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Lewis x epitope biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Lewis x epitope biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-glycan fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligosaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polysaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
Names
alpha-(1,3)-fucosyltransferase 9
fuc-TIX
fucT-IX
fucosyltransferase IX
galactoside 3-L-fucosyltransferase
NP_034373.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010243.3 → NP_034373.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

    See identical proteins and their annotated locations for NP_034373.1

    Status: VALIDATED

    Source sequence(s)
    AL935336, BB626126, BX323863
    Consensus CDS
    CCDS18011.1
    UniProtKB/Swiss-Prot
    O88819, Q3TQ63
    UniProtKB/TrEMBL
    Q14AE3
    Related
    ENSMUSP00000081826.5, ENSMUST00000084770.5
    Conserved Domains (2) summary
    pfam00852
    Location:185 → 354
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:62 → 169
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    25609333..25800003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88819.1 GenPept UniProtKB/Swiss-Prot:O88819

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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