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Fut1 fucosyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 14343, updated on 5-Mar-2024

Summary

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Official Symbol
Fut1provided by MGI
Official Full Name
fucosyltransferase 1provided by MGI
Primary source
MGI:MGI:109375
See related
Ensembl:ENSMUSG00000008461 AllianceGenome:MGI:109375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MFUT-1
Summary
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is required for the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene impairs development of the olfactory nerve and maturation of the glomerular layer of the main olfactory bulb. Alternative splicing results in multiple transcript variants which encode distinct isoforms. [provided by RefSeq, Dec 2012]
Expression
Biased expression in genital fat pad adult (RPKM 6.7), testis adult (RPKM 1.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.39 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45266862..45270483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45617606..45621059)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31479 Neighboring gene Fgf21 promoter region Neighboring gene fibroblast growth factor 21 Neighboring gene izumo sperm-egg fusion 1 Neighboring gene Ras interacting protein 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice. Yoon CH, et al. Int J Mol Sci, 2022 Aug 21. PMID 36012728, Free PMC Article
  2. Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Zhou R, et al. Cell Mol Gastroenterol Hepatol, 2021. PMID 33631374, Free PMC Article
  3. Hormonal control of H-type alpha(1-2)fucosyltransferase messenger ribonucleic acid in the mouse uterus. Sidhu SS, et al. Biol Reprod, 1999 Jan. PMID 9858499
  4. FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis. Luo J, et al. Mol Med, 2023 Apr 21. PMID 37085770, Free PMC Article
  5. Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma. Loong JH, et al. J Clin Invest, 2021 Jun 1. PMID 33878034, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.
    Title: FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.
  2. The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice.
    Title: The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice.
  3. Intestinal alpha1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice.
    Title: Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice.
  4. Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
    Title: Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
  5. miR-339-5p downregulation contributes to Taxol resistance in small-cell lung cancer by targeting FUT1.
    Title: miR-339-5p downregulation contributes to Taxol resistance in small-cell lung cancer by targeting α1,2-fucosyltransferase 1.
  6. Fut1 plays an important role in regulating angiogenesis and ICAM-1 expression in inflammatory arthritis.
    Title: A key role for Fut1-regulated angiogenesis and ICAM-1 expression in K/BxN arthritis.
  7. We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis.
    Title: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.
  8. fucosyltransferase (Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile.
    Title: Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system.
  9. These results indicate that Fut2-mediated fucosylated epithelial cells (F-ECs) share M cell-related fucosylated molecules but maintain distinctive EC characteristics, Fut1 is, therefore, a reliable marker for M cells.
    Title: Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.
  10. Vasculogenesis was the most clearly affected by FUT1 expression, suggesting that tumor angiomorphogenesis may depend on E-selectin-mediated interaction between HCC and endothelial cells, the inhibition of which remarkably retards tumor growth.
    Title: Introducing alpha(1,2)-linked fucose into hepatocarcinoma cells inhibits vasculogenesis and tumor growth.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC129302, MGC129303

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-(1,2)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables galactoside 2-alpha-L-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactoside 2-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligosaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactoside alpha-(1,2)-fucosyltransferase 1
Names
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
H transferase
alpha(1,2)FT 1
beta-galactoside alpha-1,2-fucosyltransferase
galactoside 2-alpha-L-fucosyltransferase 1
type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1
type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1
NP_001258910.1
NP_032077.2
XP_036008571.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271981.1 → NP_001258910.1  galactoside alpha-(1,2)-fucosyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001258910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 5' end of the coding exon and uses an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC149057, AK137638, BC109145
    Consensus CDS
    CCDS85303.1
    UniProtKB/TrEMBL
    Q32MG3, Q9JL28
    Related
    ENSMUSP00000147274.2, ENSMUST00000209379.2
    Conserved Domains (1) summary
    pfam01531
    Location:18 → 300
    Glyco_transf_11; Glycosyl transferase family 11

  2. NM_008051.6 → NP_032077.2  galactoside alpha-(1,2)-fucosyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_032077.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC149057, AK137638
    Consensus CDS
    CCDS21254.1
    UniProtKB/Swiss-Prot
    O09160, P97327
    UniProtKB/TrEMBL
    Q920W5, Q9JL28
    Related
    ENSMUSP00000008605.6, ENSMUST00000008605.6
    Conserved Domains (1) summary
    pfam01531
    Location:39 → 355
    Glyco_transf_11; Glycosyl transferase family 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45266862..45270483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152678.1 → XP_036008571.1  galactoside alpha-(1,2)-fucosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O09160, P97327
    UniProtKB/TrEMBL
    Q920W5, Q9JL28
    Conserved Domains (1) summary
    pfam01531
    Location:39 → 355
    Glyco_transf_11; Glycosyl transferase family 11
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09160.2 GenPept UniProtKB/Swiss-Prot:O09160

Gene LinkOut

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