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Aktip AKT interacting protein [ Mus musculus (house mouse) ]

Gene ID: 14339, updated on 21-Apr-2024

Summary

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Official Symbol
Aktipprovided by MGI
Official Full Name
AKT interacting proteinprovided by MGI
Primary source
MGI:MGI:3693832
See related
Ensembl:ENSMUSG00000031667 AllianceGenome:MGI:3693832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ft; Fif; Ft1; Fts; AL023020
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within positive regulation of protein binding activity and positive regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in nucleus. Is expressed in several structures, including ganglia; genitourinary system; hemolymphoid system gland; lung; and skin. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.7), bladder adult (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C4; 8 44.25 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (91834267..91862122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91111781..91135494, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene predicted gene 6658 Neighboring gene STARR-positive B cell enhancer ABC_E3792 Neighboring gene STARR-positive B cell enhancer ABC_E8848 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:93594488-93594671 Neighboring gene STARR-seq mESC enhancer starr_22297 Neighboring gene predicted gene, 39221 Neighboring gene predicted gene, 22428 Neighboring gene RB transcriptional corepressor like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr8:93657981-93658282 Neighboring gene STARR-positive B cell enhancer mm9_chr8:93671652-93671953 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:93684510-93684619 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene, 36243 Neighboring gene Rpgrip1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). van der Hoeven F, et al. Development, 1994 Sep. PMID 7956835
  2. p53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice. Burla R, et al. Front Genet, 2018. PMID 30546381, Free PMC Article
  3. Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. La Torre M, et al. Aging Cell, 2018 Aug. PMID 29635765, Free PMC Article
  4. The dominant mouse mutations fused toes (Ft) and oligosyndactylism (Os) are not allelic. Lesche R, et al. Mamm Genome, 1998 Jul. PMID 9657858
  5. Insertional mutagenesis affecting programmed cell death leads to thymic hyperplasia and altered thymopoiesis. Volkmann A, et al. J Immunol, 1996 Jan 1. PMID 8598454

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1.
    Title: Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1.
  2. Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.
    Title: Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.
  3. Ft1 protein is required for telomere maintenance.
    Title: AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
  4. Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.
    Title: Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.
  5. Ft genes play an important role in dorsal-ventral patterning of the neural tube acting to define the extent of motor neuron generation
    Title: Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.
  6. Owing to a deletion, six genes, including the entire IroquoisB (IrxB) gene cluster, are directly affected by the Ft mutation.
    Title: The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster.
  7. Defects in brain patterning and head morphogenesis are caused by mutations in Fused toes gene.
    Title: Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NEDD8 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
AKT-interacting protein
Names
fused toes protein
thymoma viral proto-oncogene 1 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302266.1 → NP_001289195.1  AKT-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001289195.1

    Status: VALIDATED

    Source sequence(s)
    AC122441, AK146459, BC034861, Z67963
    Consensus CDS
    CCDS22519.1
    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Related
    ENSMUSP00000119277.3, ENSMUST00000125257.3
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  2. NM_001302267.1 → NP_001289196.1  AKT-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001289196.1

    Status: VALIDATED

    Source sequence(s)
    AC122441, AK146459, BC034861, CJ153808, Z67963
    Consensus CDS
    CCDS22519.1
    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Related
    ENSMUSP00000112375.2, ENSMUST00000120213.9
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  3. NM_001302268.1 → NP_001289197.1  AKT-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001289197.1

    Status: VALIDATED

    Source sequence(s)
    AC122441, AK146459, AK158704, BC034861, Z67963
    Consensus CDS
    CCDS22519.1
    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Related
    ENSMUSP00000105238.3, ENSMUST00000109609.9
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  4. NM_001302337.1 → NP_001289266.1  AKT-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_001289266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate 3'-terminal exon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122441, AK017861, AK158704, BC034861, BM899517
    Consensus CDS
    CCDS85582.1
    UniProtKB/TrEMBL
    D3Z632, Q05BP5
    Related
    ENSMUSP00000113379.3, ENSMUST00000120426.9
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  5. NM_001358934.1 → NP_001345863.1  AKT-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122441, Z67963
    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  6. NM_001358935.1 → NP_001345864.1  AKT-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122441, Z67963
    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  7. NM_001358936.1 → NP_001345865.1  AKT-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122441, Z67963
    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  8. NM_001358937.1 → NP_001345866.1  AKT-interacting protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122441, Z67963
    Consensus CDS
    CCDS22519.1
    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  9. NM_001358938.1 → NP_001345867.1  AKT-interacting protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122441, Z67963
    Consensus CDS
    CCDS22519.1
    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  10. NM_010241.5 → NP_034371.1  AKT-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_034371.1

    Status: VALIDATED

    Source sequence(s)
    AC122441, AK146459, Z67963
    Consensus CDS
    CCDS22519.1
    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Related
    ENSMUSP00000113769.2, ENSMUST00000120349.8
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    91834267..91862122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530673.5 → XP_006530736.1  AKT-interacting protein isoform X5

    See identical proteins and their annotated locations for XP_006530736.1

    UniProtKB/TrEMBL
    D3Z632, Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  2. XM_030243297.2 → XP_030099157.1  AKT-interacting protein isoform X6

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:74 → 217
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  3. XM_030243295.2 → XP_030099155.1  AKT-interacting protein isoform X5

    UniProtKB/TrEMBL
    D3Z632, Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  4. XM_030243294.2 → XP_030099154.1  AKT-interacting protein isoform X5

    UniProtKB/TrEMBL
    D3Z632, Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  5. XM_030243296.2 → XP_030099156.1  AKT-interacting protein isoform X5

    UniProtKB/TrEMBL
    D3Z632, Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  6. XM_030243291.2 → XP_030099151.1  AKT-interacting protein isoform X3

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:74 → 217
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  7. XM_017312574.3 → XP_017168063.1  AKT-interacting protein isoform X4

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:74 → 217
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  8. XM_011248307.4 → XP_011246609.1  AKT-interacting protein isoform X3

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:74 → 217
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  9. XM_030243289.2 → XP_030099149.1  AKT-interacting protein isoform X2

    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  10. XM_011248304.4 → XP_011246606.1  AKT-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_011246606.1

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  11. XM_030243293.2 → XP_030099153.1  AKT-interacting protein isoform X4

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:74 → 217
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  12. XM_011248303.4 → XP_011246605.1  AKT-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_011246605.1

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  13. XM_030243292.2 → XP_030099152.1  AKT-interacting protein isoform X4

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:74 → 217
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  14. XM_036153758.1 → XP_036009651.1  AKT-interacting protein isoform X4

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:74 → 217
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  15. XM_011248306.4 → XP_011246608.1  AKT-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_011246608.1

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  16. XM_030243290.1 → XP_030099150.1  AKT-interacting protein isoform X2

    UniProtKB/Swiss-Prot
    Q3TYE3, Q64362
    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  17. XM_017312571.1 → XP_017168060.1  AKT-interacting protein isoform X1

    UniProtKB/TrEMBL
    Q05BP5
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64362.1 GenPept UniProtKB/Swiss-Prot:Q64362

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