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Ftcd formiminotransferase cyclodeaminase [ Mus musculus (house mouse) ]

Gene ID: 14317, updated on 5-Mar-2024

Summary

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Official Symbol
Ftcdprovided by MGI
Official Full Name
formiminotransferase cyclodeaminaseprovided by MGI
Primary source
MGI:MGI:1339962
See related
Ensembl:ENSMUSG00000001155 AllianceGenome:MGI:1339962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; and microtubule binding activity. Predicted to be involved in cytoskeleton organization. Predicted to act upstream of or within histidine catabolic process. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in glutamate formiminotransferase deficiency. Orthologous to human FTCD (formimidoyltransferase cyclodeaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 178.1), liver E18 (RPKM 58.0) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.25 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76411482..76426172)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76575648..76590338)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930483K19 gene Neighboring gene lanosterol synthase Neighboring gene spermatogenesis and centriole associated 1 like Neighboring gene predicted gene 15343 Neighboring gene collagen, type VI, alpha 2 Neighboring gene predicted gene, 51774

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis. Lapierre P, et al. Hepatology, 2010 May. PMID 20232291
  2. Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency. Solans A, et al. Cytogenet Cell Genet, 2000. PMID 10773664
  3. Cloning of mouse ojoplano, a reticular cytoplasmic protein expressed during embryonic development. Mertes F, et al. Gene Expr Patterns, 2009 Dec. PMID 19766735
  4. ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. Zahn C, et al. J Biol Chem, 2008 Oct 3. PMID 18662990
  5. Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Liu SP, et al. Hepatology, 2007 Nov. PMID 17937387

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
    Title: Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
  2. Autoreactive B cell response against formiminotransferase-cyclodeaminase correlated with disease activity, possibly linking B-cell autoreactivity and AIH pathogenesis
    Title: Forkhead box p3+ regulatory T cell underlies male resistance to experimental type 2 autoimmune hepatitis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (9) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables folic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables formimidoyltetrahydrofolate cyclodeaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables formimidoyltetrahydrofolate cyclodeaminase activity TAS
Traceable Author Statement
more info
 PubMed 
enables glutamate formimidoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamate formimidoyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within histidine catabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within histidine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in smooth endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
formimidoyltransferase-cyclodeaminase
Names
glutamate formiminotransferase
NP_543121.1
XP_006513278.1
XP_006513279.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080845.2 → NP_543121.1  formimidoyltransferase-cyclodeaminase

    See identical proteins and their annotated locations for NP_543121.1

    Status: VALIDATED

    Source sequence(s)
    AK165414, BB610765, CB949427, CD297973
    Consensus CDS
    CCDS23950.1
    UniProtKB/Swiss-Prot
    Q91XD4
    Related
    ENSMUSP00000001183.8, ENSMUST00000001183.8
    Conserved Domains (2) summary
    TIGR02024
    Location:1 → 328
    FtcD; glutamate formiminotransferase
    pfam04961
    Location:340 → 519
    FTCD_C; Formiminotransferase-cyclodeaminase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    76411482..76426172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513216.3 → XP_006513279.1  formimidoyltransferase-cyclodeaminase isoform X2

    Conserved Domains (3) summary
    pfam02971
    Location:32 → 175
    FTCD; Formiminotransferase domain
    pfam04961
    Location:190 → 363
    FTCD_C; Formiminotransferase-cyclodeaminase
    cl26845
    Location:4 → 30
    FTCD_N; Formiminotransferase domain, N-terminal subdomain

  2. XM_006513215.3 → XP_006513278.1  formimidoyltransferase-cyclodeaminase isoform X1

    Conserved Domains (2) summary
    pfam04961
    Location:323 → 496
    FTCD_C; Formiminotransferase-cyclodeaminase
    cl26845
    Location:2 → 312
    FTCD_N; Formiminotransferase domain, N-terminal subdomain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XD4.1 GenPept UniProtKB/Swiss-Prot:Q91XD4

Gene LinkOut

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