Fpgs folylpolyglutamyl synthetase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fpgsprovided by MGI
Official Full Name: folylpolyglutamyl synthetaseprovided by MGI
Primary source: MGI:MGI:95576
See related: Ensembl:ENSMUSG00000009566 AllianceGenome:MGI:95576
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in cell population proliferation; glutamate metabolic process; and tetrahydrofolylpolyglutamate biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 116.7), ovary adult (RPKM 47.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32572621..32594163, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32682609..32704196, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that FPGS and GGH expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.
Title: Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity.
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
Title: Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fpgs (e-PCR), detects polymorphism
- UniSTS:143137

RH124683 (e-PCR)
- UniSTS:161505

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acid-amino acid ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tetrahydrofolylpolyglutamate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tetrahydrofolylpolyglutamate synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in folic acid-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in folic acid-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolylpolyglutamate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolylpolyglutamate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: folylpolyglutamate synthase, mitochondrial

Names: folylpoly-gamma-glutamate synthetase; tetrahydrofolate synthase; tetrahydrofolylpolyglutamate synthase

NP_001407024.1

EC 6.3.2.17

NP_001407025.1

EC 6.3.2.17

NP_001407026.1

EC 6.3.2.17

NP_034366.2

EC 6.3.2.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420095.1 → NP_001407024.1 folylpolyglutamate synthase, mitochondrial isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL772271
NM_001420096.1 → NP_001407025.1 folylpolyglutamate synthase, mitochondrial isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL772271
NM_001420097.1 → NP_001407026.1 folylpolyglutamate synthase, mitochondrial isoform 4

Status: VALIDATED

Source sequence(s)

AL772271
NM_010236.3 → NP_034366.2 folylpolyglutamate synthase, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_034366.2

Status: VALIDATED

Source sequence(s)

AL772271

Consensus CDS

CCDS15926.1

UniProtKB/Swiss-Prot

A2AK69, P48760, Q3U0B4, Q99K38

Related

ENSMUSP00000028148.5, ENSMUST00000028148.11

Conserved Domains (2) summary

PLN02881
Location:44 → 581

PLN02881; tetrahydrofolylpolyglutamate synthase

pfam02875
Location:360 → 441

Mur_ligase_C; Mur ligase family, glutamate ligase domain