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Slc34a3 solute carrier family 34 (sodium phosphate), member 3 [ Mus musculus (house mouse) ]

Gene ID: 142681, updated on 5-Mar-2024

Summary

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Official Symbol
Slc34a3provided by MGI
Official Full Name
solute carrier family 34 (sodium phosphate), member 3provided by MGI
Primary source
MGI:MGI:2159410
See related
Ensembl:ENSMUSG00000006469 AllianceGenome:MGI:2159410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npt2c; NptIIc; naPi-2c; Npt2c-v1
Summary
Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane and brush border. Is expressed in several structures, including extraembryonic component; genitourinary system; and small intestine. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 74.2) See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 17.09 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25118909..25124282, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25228897..25234270, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm tail PG rich repeat containing 3 Neighboring gene ciliary microtubule inner protein 2A Neighboring gene tubulin, beta 4B class IVB Neighboring gene STARR-seq mESC enhancer starr_03963 Neighboring gene ring finger protein 224 Neighboring gene cysteine rich tail 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation. Fujii T, et al. Clin Exp Nephrol, 2019 Jul. PMID 30895530
  2. Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice. Myakala K, et al. Am J Physiol Renal Physiol, 2014 Apr 15. PMID 24553430
  3. Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c. Kuwahara S, et al. J Med Invest, 2012. PMID 22450000
  4. Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter. Bacconi A, et al. Proc Natl Acad Sci U S A, 2005 Aug 30. PMID 16113079, Free PMC Article
  5. Response of Npt2a knockout mice to dietary calcium and phosphorus. Li Y, et al. PLoS One, 2017. PMID 28448530, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages.
    Title: Role of sodium-dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages.
  2. Acute regulation of NaPi-IIc protein by parathyroid hormone is involved in the inactivation of Na(+)-dependent Pi cotransporter activity and that phosphorylation of the transporter is involved in the rapid modification.
    Title: Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.
  3. Nampt/NAD(+) system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels.
    Title: The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of plasma inorganic phosphate concentration.
  4. we have generated a renal-specific and inducible knockout model of NaPi-IIc/Slc34a3. absence of NaPi-IIc does not disturb the homeostasis of Pi in mice. However, ablation of the cotransporter in weaning mice does not alter the homeostasis of Ca2+.
    Title: Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice.
  5. The expression of Npt2c-v1 mRNA was detected in the heart, spleen, testis, uterus, placenta, femur, cerebellum, hippocampus, diencephalon and brain stem and sperm of mouse.
    Title: Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c.
  6. reduced intestinal Pi absorption in VDR (-/-) mice does not seem to be the only factor that causes hypophosphatemia; reduced Npt2a, Npt2c, or PiT-2 protein levels during development might also cause hypophosphatemia and rickets in VDR (-/-) mice.
    Title: Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.
  7. Targeting of NaPi-IIc to the apical surface of renal epithelial cells is regulated by a unique amino acid motif in the cytoplasmic C-terminal domain.
    Title: An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.
  8. Findings suggest that Npt2a, Npt2c, and PiT-2 are necessary for the phosphaturic activity of FGF23.
    Title: Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.
  9. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.
    Title: Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.
  10. FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
    Title: FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC159029

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sodium:phosphate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:phosphate symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sodium:phosphate symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular phosphate ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphate ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphate ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium-dependent phosphate transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-dependent phosphate transport protein 2C
Names
Na(+)-dependent phosphate cotransporter 2C
Na(+)/Pi cotransporter 2C
sodium-phosphate cotransporter IIC
sodium/phosphate cotransporter 2C
type IIc Na+/Pi-cotransporter
type IIc NaPi-cotransporter-v1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362748.1 → NP_001349677.1  sodium-dependent phosphate transport protein 2C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL732309
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19 → 505
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  2. NM_080854.3 → NP_543130.2  sodium-dependent phosphate transport protein 2C isoform 1

    See identical proteins and their annotated locations for NP_543130.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL732309, BC125326
    Consensus CDS
    CCDS15754.1
    UniProtKB/Swiss-Prot
    Q05AC3, Q80SU6
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Related
    ENSMUSP00000006638.8, ENSMUST00000006638.8
    Conserved Domains (1) summary
    TIGR01013
    Location:79 → 565
    2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25118909..25124282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497681.3 → XP_006497744.1  sodium-dependent phosphate transport protein 2C isoform X5

    See identical proteins and their annotated locations for XP_006497744.1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19 → 505
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  2. XM_006497683.3 → XP_006497746.1  sodium-dependent phosphate transport protein 2C isoform X5

    See identical proteins and their annotated locations for XP_006497746.1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19 → 505
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  3. XM_006497679.2 → XP_006497742.1  sodium-dependent phosphate transport protein 2C isoform X3

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:72 → 558
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  4. XM_006497677.2 → XP_006497740.1  sodium-dependent phosphate transport protein 2C isoform X2

    See identical proteins and their annotated locations for XP_006497740.1

    UniProtKB/Swiss-Prot
    Q05AC3, Q80SU6
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:79 → 565
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  5. XM_011239018.2 → XP_011237320.1  sodium-dependent phosphate transport protein 2C isoform X4

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:87 → 543
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  6. XM_011239017.2 → XP_011237319.1  sodium-dependent phosphate transport protein 2C isoform X1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:87 → 573
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  7. XM_006497678.2 → XP_006497741.1  sodium-dependent phosphate transport protein 2C isoform X2

    See identical proteins and their annotated locations for XP_006497741.1

    UniProtKB/Swiss-Prot
    Q05AC3, Q80SU6
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:79 → 565
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  8. XM_017315536.2 → XP_017171025.1  sodium-dependent phosphate transport protein 2C isoform X1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:87 → 573
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  9. XM_017315541.2 → XP_017171030.1  sodium-dependent phosphate transport protein 2C isoform X5

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19 → 505
    2a58; Phosphate:Na+ Symporter (PNaS) Family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80SU6.2 GenPept UniProtKB/Swiss-Prot:Q80SU6

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