Fmod fibromodulin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fmodprovided by MGI
Official Full Name: fibromodulinprovided by MGI
Primary source: MGI:MGI:1328364
See related: Ensembl:ENSMUSG00000041559 AllianceGenome:MGI:1328364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FM; SLRR2E
Summary: Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; heart and pericardium; intraembryonic coelom; jaw; and skeleton. Orthologous to human FMOD (fibromodulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 35.1), genital fat pad adult (RPKM 32.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.09 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (133964992..133976018)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134037254..134048280)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation.
Title: Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation.
Extracellular matrix components and elasticity regulate mouse vaginal epithelial differentiation induced by mesenchymal cellsdagger.
Title: Extracellular matrix components and elasticity regulate mouse vaginal epithelial differentiation induced by mesenchymal cells†.
Interaction of Fibromodulin and Myostatin to Regulate Skeletal Muscle Aging: An Opposite Regulation in Muscle Aging, Diabetes, and Intracellular Lipid Accumulation.
Title: Interaction of Fibromodulin and Myostatin to Regulate Skeletal Muscle Aging: An Opposite Regulation in Muscle Aging, Diabetes, and Intracellular Lipid Accumulation.
OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
Title: OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
Influence of microcurrent on the modulation of remodelling genes in a wound healing assay.
Title: Influence of microcurrent on the modulation of remodelling genes in a wound healing assay.
this study suggests that downregulation of miR-340-5p plays a role in promoting cell proliferation and suppressing cell apoptosis of chondrocytes in Osteoarthritis (OA) mice through inhibition of the ERK signaling pathway via the FMOD gene.
Title: Downregulated microRNA-340-5p promotes proliferation and inhibits apoptosis of chondrocytes in osteoarthritis mice through inhibiting the extracellular signal-regulated kinase signaling pathway by negatively targeting the FMOD gene.
our data indicates that Bgn and Fmod expressed by the bone forming cells, are novel coupling ECM components that control bone mass through sequestration of TNFalpha and/or RANKL, thereby adjusting their bioavailability in order to regulate osteoclastogenesis.
Title: Small leucine rich proteoglycans, a novel link to osteoclastogenesis.
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.
Title: The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.
FMOD affected the expressions of the Cav1.1 and Cav3.1 genes. FMOD regulates calcium channel activity. The mRNA expressions of Cav1.1 and Cav3.1 increased during muscle regeneration.
Title: Fibromodulin modulates myoblast differentiation by controlling calcium channel.
Studies in knockout, obese, and diabetic mouse models helped characterize the operation of a novel FMOD-based regulatory circuit that controls myoblast switching from a myogenic to a lipid accumulation fate. FMOD regulation of myoblasts is an essential part of the myogenic program, and it offers opportunities for the development of therapeutics for the treatment of different muscle diseases
Title: Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte-like cells.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC133870P1 (e-PCR)
- UniSTS:270674

Fmod (e-PCR), detects polymorphism
- UniSTS:531312

AI131919 (e-PCR)
- UniSTS:158854

RH118245 (e-PCR)
- UniSTS:160918

NoName (e-PCR)
- UniSTS:234211

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibromodulin

Names: KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate proteoglycan fibromodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021355.4 → NP_067330.1 fibromodulin precursor

See identical proteins and their annotated locations for NP_067330.1

Status: VALIDATED

Source sequence(s)

AC154872, AK032302

Consensus CDS

CCDS15301.1

UniProtKB/Swiss-Prot

P50608

UniProtKB/TrEMBL

Q543D2, Q8BNU3

Related

ENSMUSP00000035489.8, ENSMUST00000048183.8

Conserved Domains (4) summary

smart00013
Location:75 → 109

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:136 → 359

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:107 → 130

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:176 → 235

LRR_8; Leucine rich repeat