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Fmo5 flavin containing monooxygenase 5 [ Mus musculus (house mouse) ]

Gene ID: 14263, updated on 21-Apr-2024

Summary

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Official Symbol
Fmo5provided by MGI
Official Full Name
flavin containing monooxygenase 5provided by MGI
Primary source
MGI:MGI:1310004
See related
Ensembl:ENSMUSG00000028088 AllianceGenome:MGI:1310004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5033418D19Rik
Summary
Predicted to enable N,N-dimethylaniline monooxygenase activity and aldehyde oxidase activity. Involved in regulation of cholesterol metabolic process. Predicted to be located in cytosol and endoplasmic reticulum. Is expressed in bladder. Orthologous to human FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 151.5), liver adult (RPKM 23.9) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 42.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97517248..97562603)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97609938..97655287)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 13 subfamily L member 2 Neighboring gene STARR-seq mESC enhancer starr_08465 Neighboring gene STARR-seq mESC enhancer starr_08467 Neighboring gene STARR-seq mESC enhancer starr_08468 Neighboring gene predicted gene, 40102 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene protein kinase, AMP-activated, beta 2 non-catalytic subunit Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism. Phillips IR, et al. PLoS One, 2023. PMID 37267233, Free PMC Article
  2. Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice. Varshavi D, et al. Front Mol Biosci, 2018. PMID 29686991, Free PMC Article
  3. Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis. Veeravalli S, et al. Drug Metab Dispos, 2018 Jan. PMID 29070510, Free PMC Article
  4. Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria. Scott F, et al. Drug Metab Dispos, 2017 Sep. PMID 28646079, Free PMC Article
  5. Drug metabolism by flavin-containing monooxygenases of human and mouse. Phillips IR, et al. Expert Opin Drug Metab Toxicol, 2017 Feb. PMID 27678284

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism.
    Title: Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism.
  2. Hepatic Fmo5 displayed diurnal rhythmicities in expression and activity in mice.
    Title: The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver.
  3. Fmo5(-)(/)(-) mice have metabolic characteristics similar to those of germ-free mice, indicating that FMO5 plays a role in sensing or responding to gut bacteria. In WT mice, FMO5 is present in the mucosal epithelium of the gastrointestinal tract where it is induced in response to a high-fat diet.
    Title: Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.
  4. The phenotype of a knockout mouse identifies FMO5 as a regulator of metabolic aging.
    Title: The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.
  5. The functional activity of Fmo5 was determined.
    Title: Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD(P)H oxidase H2O2-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
flavin-containing monooxygenase 5
Names
NADPH oxidase
NAPDH oxidase
dimethylaniline monooxygenase [N-oxide-forming] 5
dimethylaniline oxidase 5
hepatic flavin-containing monooxygenase 5
NP_001155235.1
NP_001155237.1
NP_001342048.1
NP_034362.2
XP_006501058.1
XP_006501059.1
XP_011238315.1
XP_030108278.1
XP_030108279.1
XP_030108280.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161763.1 → NP_001155235.1  flavin-containing monooxygenase 5 isoform 1

    See identical proteins and their annotated locations for NP_001155235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC130541, AK133675, AK162951
    Consensus CDS
    CCDS17656.1
    UniProtKB/Swiss-Prot
    P97872, Q8R1W6
    Related
    ENSMUSP00000102665.2, ENSMUST00000107050.8
    Conserved Domains (1) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like

  2. NM_001161765.1 → NP_001155237.1  flavin-containing monooxygenase 5 isoform 1

    See identical proteins and their annotated locations for NP_001155237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC130541, AC140839, AK133675
    Consensus CDS
    CCDS17656.1
    UniProtKB/Swiss-Prot
    P97872, Q8R1W6
    Related
    ENSMUSP00000102664.2, ENSMUST00000107049.2
    Conserved Domains (1) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like

  3. NM_001355119.1 → NP_001342048.1  flavin-containing monooxygenase 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130541, AC140839
    Conserved Domains (1) summary
    pfam00743
    Location:1 → 466
    FMO-like; Flavin-binding monooxygenase-like

  4. NM_010232.5 → NP_034362.2  flavin-containing monooxygenase 5 isoform 1

    See identical proteins and their annotated locations for NP_034362.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC130541, AK133675, AK162951, CN664821
    Consensus CDS
    CCDS17656.1
    UniProtKB/Swiss-Prot
    P97872, Q8R1W6
    Related
    ENSMUSP00000029729.9, ENSMUST00000029729.15
    Conserved Domains (1) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    97517248..97562603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500995.5 → XP_006501058.1  flavin-containing monooxygenase 5 isoform X1

    See identical proteins and their annotated locations for XP_006501058.1

    UniProtKB/Swiss-Prot
    P97872, Q8R1W6
    Conserved Domains (1) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like

  2. XM_030252419.1 → XP_030108279.1  flavin-containing monooxygenase 5 isoform X3

    Conserved Domains (1) summary
    pfam00743
    Location:3 → 397
    FMO-like; Flavin-binding monooxygenase-like

  3. XM_030252420.1 → XP_030108280.1  flavin-containing monooxygenase 5 isoform X3

    Conserved Domains (1) summary
    pfam00743
    Location:3 → 397
    FMO-like; Flavin-binding monooxygenase-like

  4. XM_011240013.3 → XP_011238315.1  flavin-containing monooxygenase 5 isoform X3

    Conserved Domains (1) summary
    pfam00743
    Location:3 → 397
    FMO-like; Flavin-binding monooxygenase-like

  5. XM_030252418.1 → XP_030108278.1  flavin-containing monooxygenase 5 isoform X2

    Conserved Domains (1) summary
    pfam00743
    Location:1 → 466
    FMO-like; Flavin-binding monooxygenase-like

  6. XM_006500996.2 → XP_006501059.1  flavin-containing monooxygenase 5 isoform X2

    See identical proteins and their annotated locations for XP_006501059.1

    Conserved Domains (1) summary
    pfam00743
    Location:1 → 466
    FMO-like; Flavin-binding monooxygenase-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97872.4 GenPept UniProtKB/Swiss-Prot:P97872

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