Fmo3 flavin containing monooxygenase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fmo3provided by MGI
Official Full Name: flavin containing monooxygenase 3provided by MGI
Primary source: MGI:MGI:1100496
See related: Ensembl:ENSMUSG00000026691 AllianceGenome:MGI:1100496
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 25.6) and lung adult (RPKM 4.5) See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 70.34 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (162781368..162812097, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (162953799..162984528, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver.
Title: Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver.
Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.
Title: Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.
In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice.
Title: In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice.
TMAO could be associated with increased hepatic Abcg5/g8 expression, biliary cholesterol hypersecretion and gallstone formation.
Title: FMO3 and its metabolite TMAO contribute to the formation of gallstones.
Suppression of fmo3 by antisense oligonucleotides reduces TMAO levels, and platelet adhesion to matrix in whole blood under physiological sheer stress, but does not impact tail bleeding time. Host hepatic FMO3, the terminal step in the metaorganismal TMAO pathway, participates in diet-dependent and gut microbiota-dependent changes in both platelet responsiveness and thrombosis potential in vivo.
Title: Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.
our findings indicated that acrolein-enhanced atherogenesis by increasing FMO3 which increased inflammatory responses and decreased ABCA1 in vitro can be alleviated by Hydroxytyrosol (HT), which may have a therapeutic potential for the treatment of atherosclerosis.
Title: Acrolein-induced atherogenesis by stimulation of hepatic flavin containing monooxygenase 3 and a protection from hydroxytyrosol.
Diabetes induced the expression of both Fmo3 and ICAM expression and possible vascular impairment through enteric dysbiosis. Diabetes-induced Fmo3 and ICAM expression could be reversed by pJNK inhibition or by correcting enteric dysbiosis.
Title: Lactobacillus plantarum reverse diabetes-induced Fmo3 and ICAM expression in mice through enteric dysbiosis-related c-Jun NH2-terminal kinase pathways.
The suppression of FMO3 metabolism related to reversible S-nitrosyl modifications of iNOS-derived NO in type 1 allergic mice.
Title: Hepatic Flavin-Containing Monooxygenase 3 Enzyme Suppressed by Type 1 Allergy-Produced Nitric Oxide.
knockdown or genetic deletion of the TMAO-producing enzyme flavin-containing monooxygenase 3 (FMO3) confers protection against obesity in mice.
Title: The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.
FMO3 can contribute to the regulation of glucose metabolism in the liver by reducing lipid-induced endoplasmic reticulum stress and the expression of PEPCK, independently of insulin signal transduction.
Title: Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N,N-dimethylaniline monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables albendazole monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables hypotaurine dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables trimethylamine monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in taurine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: flavin-containing monooxygenase 3

Names: dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; hepatic flavin-containing monooxygenase 3; trimethylamine monooxygenase

NP_032056.1

EC 1.14.13.148

EC 1.14.13.32

EC 1.14.13.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008030.2 → NP_032056.1 flavin-containing monooxygenase 3

See identical proteins and their annotated locations for NP_032056.1

Status: VALIDATED

Source sequence(s)

AK050123, AK149440, D18023

Consensus CDS

CCDS15426.1

UniProtKB/Swiss-Prot

P97501

UniProtKB/TrEMBL

Q3UEN4

Related

ENSMUSP00000028010.8, ENSMUST00000028010.9

Conserved Domains (2) summary

pfam00743
Location:2 → 533

FMO-like; Flavin-binding monooxygenase-like

cl21454
Location:6 → 220

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins