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Flot2 flotillin 2 [ Mus musculus (house mouse) ]

Gene ID: 14252, updated on 21-Apr-2024

Summary

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Official Symbol
Flot2provided by MGI
Official Full Name
flotillin 2provided by MGI
Primary source
MGI:MGI:103309
See related
Ensembl:ENSMUSG00000061981 AllianceGenome:MGI:103309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Esa; reggie-2
Summary
Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in anterograde dendritic transport and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within regulation of myoblast differentiation. Located in acrosomal membrane and caveola. Part of flotillin complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human FLOT2 (flotillin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 67.2), mammary gland adult (RPKM 55.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.74 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77928757..77951260)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78037931..78060434)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 12 Neighboring gene predicted gene, 51908 Neighboring gene STARR-positive B cell enhancer ABC_E10693 Neighboring gene dehydrogenase/reductase 13, opposite strand Neighboring gene dehydrogenase/reductase 13 Neighboring gene predicted gene, 57805 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene microRNA 144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Flot2 component of the lipid raft changes localization during neural differentiation of P19C6 cells. Hanafusa K, et al. BMC Mol Cell Biol, 2019 Aug 27. PMID 31455216, Free PMC Article
  2. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Compeer EB, et al. Nat Commun, 2018 Apr 23. PMID 29686427, Free PMC Article
  3. Expression of Flotilin-2 and Acrosome Biogenesis Are Regulated by MiR-124 during Spermatogenesis. Wu Y, et al. PLoS One, 2015. PMID 26313572, Free PMC Article
  4. Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons. Lu Z, et al. Neurosci Lett, 2014 Jan 24. PMID 24287376
  5. Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model. Banning A, et al. Cell Signal, 2014 Feb. PMID 24216609

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock.
    Title: Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock.
  2. Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.
    Title: Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.
  3. Flot2 lipid rafts are associated with Fyn, and that Fyn phosphorylates Flot2 during neural differentiation of P19C6 cells.
    Title: The Flot2 component of the lipid raft changes localization during neural differentiation of P19C6 cells.
  4. the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported.
    Title: Flotillins in the intercalated disc are potential modulators of cardiac excitability.
  5. This study suggests that reggie-1 and reggie-2 function at Rab11a recycling containers in the transport of PSD-95, N-cadherin, GluA1 and GluN1, and promote (together with significant signaling molecules) spine-directed trafficking, spine synapse formation and the in vitro correlate of LTP.
    Title: Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons.
  6. These results indicated that miR-124 could potentially play a role in caveolin-independent vesicle trafficking and modulation of flotillin-2 expression in mouse acrosome biogenesis.
    Title: Expression of Flotilin-2 and Acrosome Biogenesis Are Regulated by MiR-124 during Spermatogenesis.
  7. The role of flotillin 1 and flotillin 2 in regulating amyloid beta production in a mouse model of cerebral amyloidosis, remains unlear.
    Title: The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice.
  8. Curcumin mediates neurite outgrowth through activation of the reggie-1 pathway.
    Title: Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons.
  9. The genetic ablation of flotillin-2 in a mouse model or its knockdown in cultured cells increases extracellular signal regulated kinase (ERK) activation.
    Title: Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.
  10. upregulation of reggie-1 in mammalian neurons provides nerve cells with neuron-intrinsic properties required for axon growth and successful regeneration
    Title: Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde dendritic transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anterograde dendritic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of establishment of T cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of myoblast differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in caveola IDA
Inferred from Direct Assay
more info
 PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
part_of flotillin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of flotillin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of flotillin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in uropod ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
flotillin-2
Names
epidermal surface antigen
membrane component chromosome 17 surface marker 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040403.2 → NP_001035493.1  flotillin-2 isoform 1

    See identical proteins and their annotated locations for NP_001035493.1

    Status: VALIDATED

    Source sequence(s)
    AL669840, BC070423, BY204171, CD774654
    Consensus CDS
    CCDS36237.1
    UniProtKB/Swiss-Prot
    Q5SS82, Q60634, Q6NS75
    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Related
    ENSMUSP00000072136.6, ENSMUST00000072289.12
    Conserved Domains (2) summary
    COG2268
    Location:6 → 417
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:34 → 178
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_001284227.2 → NP_001271156.1  flotillin-2 isoform 3

    See identical proteins and their annotated locations for NP_001271156.1

    Status: VALIDATED

    Source sequence(s)
    AK149530, AL669840, BC070423, BY195482, CD774654
    UniProtKB/TrEMBL
    Q3UEG9, Q8CDE0, Q9DC36
    Conserved Domains (3) summary
    smart00244
    Location:115 → 297
    PHB; prohibitin homologues
    cd03399
    Location:72 → 206
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam15975
    Location:341 → 415
    Flot; Flotillin

  3. NM_001284228.3 → NP_001271157.1  flotillin-2 isoform 2

    See identical proteins and their annotated locations for NP_001271157.1

    Status: VALIDATED

    Source sequence(s)
    AL669840, BC070423, CD774654, U07890
    Consensus CDS
    CCDS25088.1
    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Related
    ENSMUST00000136353.2
    Conserved Domains (2) summary
    COG2268
    Location:1 → 368
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  4. NM_001362625.1 → NP_001349554.1  flotillin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL669840, CD774654
    Consensus CDS
    CCDS88200.1
    UniProtKB/TrEMBL
    Q5SS83, Q8CDE0, Q9DC36
    Related
    ENSMUSP00000073342.7, ENSMUST00000073660.7
    Conserved Domains (2) summary
    COG2268
    Location:6 → 417
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:34 → 178
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  5. NM_001362626.1 → NP_001349555.1  flotillin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669840, CD774654
    Consensus CDS
    CCDS25088.1
    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Conserved Domains (2) summary
    COG2268
    Location:1 → 368
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  6. NM_001362627.1 → NP_001349556.1  flotillin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669840, CD774654
    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Conserved Domains (2) summary
    COG2268
    Location:8 → 340
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 101
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  7. NM_008028.4 → NP_032054.1  flotillin-2 isoform 2

    See identical proteins and their annotated locations for NP_032054.1

    Status: VALIDATED

    Source sequence(s)
    AK149530, AL669840, BC070423, BY195482, CD774654
    Consensus CDS
    CCDS25088.1
    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Related
    ENSMUSP00000098347.3, ENSMUST00000100784.9
    Conserved Domains (2) summary
    COG2268
    Location:1 → 368
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77928757..77951260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245558.1 → XP_030101418.1  flotillin-2 isoform X3

    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Conserved Domains (2) summary
    COG2268
    Location:8 → 340
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 101
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_030245557.2 → XP_030101417.1  flotillin-2 isoform X1

    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Conserved Domains (2) summary
    COG2268
    Location:7 → 380
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:7 → 141
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. XM_036156327.1 → XP_036012220.1  flotillin-2 isoform X2

    UniProtKB/TrEMBL
    Q8CDE0, Q9DC36
    Conserved Domains (2) summary
    COG2268
    Location:1 → 368
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:1 → 129
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60634.2 GenPept UniProtKB/Swiss-Prot:Q60634

Gene LinkOut

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