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Foxn2 forkhead box N2 [ Mus musculus (house mouse) ]

Gene ID: 14236, updated on 5-Mar-2024

Summary

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Official Symbol
Foxn2provided by MGI
Official Full Name
forkhead box N2provided by MGI
Primary source
MGI:MGI:1347478
See related
Ensembl:ENSMUSG00000034998 AllianceGenome:MGI:1347478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HTLF; Fkh19; Foxn1; 3230402J05Rik; 6030465J18Rik
Summary
Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; limb bud; and nervous system. Orthologous to human FOXN2 (forkhead box N2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.0), cerebellum adult (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E4; 17 57.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88746430..88797961)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (88440704..88490533)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31615 Neighboring gene STARR-seq mESC enhancer starr_43551 Neighboring gene predicted gene, 22542 Neighboring gene STARR-seq mESC enhancer starr_43553 Neighboring gene predicted gene, 23947 Neighboring gene STARR-positive B cell enhancer ABC_E5644 Neighboring gene STARR-seq mESC enhancer starr_43555 Neighboring gene STARR-seq mESC enhancer starr_43556 Neighboring gene predicted gene, 57646 Neighboring gene STARR-seq mESC enhancer starr_43557 Neighboring gene STARR-seq mESC enhancer starr_43559 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88929251-88929552 Neighboring gene protein phosphatase 1, regulatory subunit 21 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88980789-88981089 Neighboring gene stonin 1 Neighboring gene predicted gene, 31704

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of mouse and human nude genes. Schorpp M, et al. Immunogenetics, 1997. PMID 9321431
  2. The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis. Tribioli C, et al. Mech Dev, 2002 Oct. PMID 12351180
  3. Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Wu J, et al. Proc Natl Acad Sci U S A, 2014 Jul 15. PMID 24982181, Free PMC Article
  4. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
  5. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The dynamic and specific expression of Foxn2 during embryonic development suggest multiple independent roles for Foxn2 function during gestation
    Title: The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
forkhead box protein N2
Names
forkhead box N1
forkhead homolog 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355742.1 → NP_001342671.1  forkhead box protein N2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165091, AW495021
    Consensus CDS
    CCDS29022.2
    UniProtKB/TrEMBL
    E9Q7L6
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  2. NM_001355743.1 → NP_001342672.1  forkhead box protein N2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165091, AW495021
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  3. NM_180974.5 → NP_851305.2  forkhead box protein N2 isoform 1

    See identical proteins and their annotated locations for NP_851305.2

    Status: VALIDATED

    Source sequence(s)
    AK086861, AK162076, AW495021, BB042729, BU152350, CB524750, CJ145725, CJ173433, CN698353, CO431378
    Consensus CDS
    CCDS29022.2
    UniProtKB/TrEMBL
    E9Q7L6
    Related
    ENSMUSP00000107857.3, ENSMUST00000112238.9
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    88746430..88797961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160317.1 → XP_036016210.1  forkhead box protein N2 isoform X1

    UniProtKB/TrEMBL
    E9Q7L6
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  2. XM_036160319.1 → XP_036016212.1  forkhead box protein N2 isoform X2

    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  3. XM_036160320.1 → XP_036016213.1  forkhead box protein N2 isoform X3

    UniProtKB/TrEMBL
    O08673, Q8BSS2
    Conserved Domains (1) summary
    cl00061
    Location:111 → 192
    FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins

  4. XM_036160318.1 → XP_036016211.1  forkhead box protein N2 isoform X2

    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  5. XM_006523653.5 → XP_006523716.1  forkhead box protein N2 isoform X1

    See identical proteins and their annotated locations for XP_006523716.1

    UniProtKB/TrEMBL
    E9Q7L6
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  6. XM_036160316.1 → XP_036016209.1  forkhead box protein N2 isoform X1

    UniProtKB/TrEMBL
    E9Q7L6
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  7. XM_030249498.2 → XP_030105358.1  forkhead box protein N2 isoform X2

    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  8. XM_006523654.4 → XP_006523717.1  forkhead box protein N2 isoform X1

    See identical proteins and their annotated locations for XP_006523717.1

    UniProtKB/TrEMBL
    E9Q7L6
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  9. XM_006523652.3 → XP_006523715.1  forkhead box protein N2 isoform X1

    See identical proteins and their annotated locations for XP_006523715.1

    UniProtKB/TrEMBL
    E9Q7L6
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

  10. XM_030249497.2 → XP_030105357.1  forkhead box protein N2 isoform X1

    UniProtKB/TrEMBL
    E9Q7L6
    Conserved Domains (1) summary
    cd20058
    Location:111 → 192
    FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

RNA

  1. XR_004939467.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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