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Fkbp8 FK506 binding protein 8 [ Mus musculus (house mouse) ]

Gene ID: 14232, updated on 21-Apr-2024

Summary

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Official Symbol
Fkbp8provided by MGI
Official Full Name
FK506 binding protein 8provided by MGI
Primary source
MGI:MGI:1341070
See related
Ensembl:ENSMUSG00000019428 AllianceGenome:MGI:1341070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
38kDa; FKBP-8; Fkbp38; FKBP-38; FKBPR38; mFKBP38
Summary
Enables protein folding chaperone. Acts upstream of or within several processes, including dorsal/ventral neural tube patterning; positive regulation of BMP signaling pathway; and smoothened signaling pathway. Located in mitochondrial envelope. Is integral component of endoplasmic reticulum membrane. Is expressed in embryo. Used to study clubfoot. Orthologous to human FKBP8 (FKBP prolyl isomerase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 130.6), colon adult (RPKM 114.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70980371..70987978)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70527721..70535328)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930522P08 gene Neighboring gene STARR-positive B cell enhancer ABC_E5013 Neighboring gene STARR-seq mESC enhancer starr_21774 Neighboring gene KxDL motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9315 Neighboring gene predicted gene, 51534 Neighboring gene STARR-positive B cell enhancer ABC_E2264 Neighboring gene elongation factor RNA polymerase II Neighboring gene STARR-positive B cell enhancer ABC_E1369 Neighboring gene myo-inositol 1-phosphate synthase A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice. Misaka T, et al. J Mol Cell Cardiol, 2018 Jan. PMID 29129702, Free PMC Article
  2. Temporal expression pattern of Fkbp8 in rodent cochlea. Zak M, et al. Cell Physiol Biochem, 2011. PMID 22178952
  3. Fkbp8: novel isoforms, genomic organization, and characterization of a forebrain promoter in transgenic mice. Nielsen JV, et al. Genomics, 2004 Jan. PMID 14667822
  4. [Fkbp38 deletion induces premature ovarian insufficiency in mice by activating mTOR signaling and inducing granulosa cell apoptosis]. Zhou Y, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Nov 20. PMID 36504053, Free PMC Article
  5. FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions. Yoo SM, et al. FASEB J, 2020 Feb. PMID 31908024

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
    Title: Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease.
  2. [Fkbp38 deletion induces premature ovarian insufficiency in mice by activating mTOR signaling and inducing granulosa cell apoptosis].
    Title: [Fkbp38 deletion induces premature ovarian insufficiency in mice by activating mTOR signaling and inducing granulosa cell apoptosis].
  3. FKBP8 variants are risk factors for spina bifida.
    Title: FKBP8 variants are risk factors for spina bifida.
  4. FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
    Title: FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
  5. FKBP8 plays a protective role against hemodynamic stress in the heart mediated via inhibition of the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis.
    Title: FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice.
  6. ZMYND10 is a novel co-chaperone that confers specificity for the FKBP8-HSP90 chaperone complex towards axonemal dynein clients required for cilia motility.
    Title: ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
  7. Our findings thus indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo.
    Title: Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway.
  8. A total of 54 genes were determined to be differentially expressed (25 downregulated, 29 upregulated) in the FKBP8Gt((neo)) mouse embryos.
    Title: Transcriptional analyses of two mouse models of spina bifida.
  9. In pre-hearing time Fkbp8-specific signal was also observed in the tectorial membrane, whose alpha- and beta-Tectorin components show similar time-dependent expression of mRNA as Fkbp8.
    Title: Temporal expression pattern of Fkbp8 in rodent cochlea.
  10. Data indicate that PHD2 protein stability is regulated by a ubiquitin-independent proteasomal pathway involving FKBP38 as adaptor protein that mediates proteasomal interaction.
    Title: Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein folding ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP8
Names
38 kDa FK506-binding protein
38 kDa FKBP
FK506-binding protein 38
PPIase FKBP8
rotamase
NP_001104536.1
NP_001186560.1
NP_034353.2
XP_006509619.1
XP_017168056.1
XP_017168057.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111066.1 → NP_001104536.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform a

    See identical proteins and their annotated locations for NP_001104536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform a). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AK165281, BB842097, DV644627
    Consensus CDS
    CCDS52575.1
    UniProtKB/TrEMBL
    C9K0Z7
    Related
    ENSMUSP00000074935.8, ENSMUST00000075491.14
    Conserved Domains (3) summary
    COG0457
    Location:206 → 329
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 292
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. NM_001199631.1 → NP_001186560.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform a

    See identical proteins and their annotated locations for NP_001186560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AC157774, AK165281, DV644627
    Consensus CDS
    CCDS52575.1
    UniProtKB/TrEMBL
    C9K0Z7
    Related
    ENSMUSP00000114069.2, ENSMUST00000119698.8
    Conserved Domains (3) summary
    COG0457
    Location:206 → 329
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 292
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  3. NM_010223.2 → NP_034353.2  peptidyl-prolyl cis-trans isomerase FKBP8 isoform b

    See identical proteins and their annotated locations for NP_034353.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, compared to variant 1. The resulting protein (isoform b) is one amino acid shorter than isoform a.
    Source sequence(s)
    AK165281, BB842097, DV644627
    Consensus CDS
    CCDS52576.1
    UniProtKB/Swiss-Prot
    O35465, Q3UK86, Q6GTX9, Q811M7, Q811R4, Q8C2F0, Q99L93
    UniProtKB/TrEMBL
    C9K0Z7
    Related
    ENSMUSP00000112527.3, ENSMUST00000119353.9
    Conserved Domains (3) summary
    COG0457
    Location:205 → 328
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:244 → 291
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 191
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70980371..70987978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312567.3 → XP_017168056.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X2

    UniProtKB/Swiss-Prot
    O35465, Q3UK86, Q6GTX9, Q811M7, Q811R4, Q8C2F0, Q99L93
    UniProtKB/TrEMBL
    C9K0Z7
    Conserved Domains (3) summary
    COG0457
    Location:205 → 328
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:244 → 291
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 191
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. XM_006509556.4 → XP_006509619.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

    See identical proteins and their annotated locations for XP_006509619.1

    UniProtKB/TrEMBL
    C9K0Z7
    Conserved Domains (3) summary
    COG0457
    Location:206 → 329
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 292
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  3. XM_017312568.2 → XP_017168057.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X2

    UniProtKB/Swiss-Prot
    O35465, Q3UK86, Q6GTX9, Q811M7, Q811R4, Q8C2F0, Q99L93
    UniProtKB/TrEMBL
    C9K0Z7
    Conserved Domains (3) summary
    COG0457
    Location:205 → 328
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:244 → 291
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 191
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RNA

  1. XR_379034.4 RNA Sequence

  2. XR_001778406.2 RNA Sequence

  3. XR_003947234.2 RNA Sequence

  4. XR_004934771.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35465.2 GenPept UniProtKB/Swiss-Prot:O35465

Gene LinkOut

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