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Fjx1 four jointed box 1 [ Mus musculus (house mouse) ]

Gene ID: 14221, updated on 8-May-2024

Summary

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Official Symbol
Fjx1provided by MGI
Official Full Name
four jointed box 1provided by MGI
Primary source
MGI:MGI:1341907
See related
Ensembl:ENSMUSG00000075012 AllianceGenome:MGI:1341907
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Acts upstream of or within retina layer formation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and genitourinary system. Orthologous to human FJX1 (four-jointed box kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
2 E2; 2 54.13 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102279711..102282137, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102449366..102451792, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 44 Neighboring gene predicted gene, 52521 Neighboring gene STARR-positive B cell enhancer ABC_E3386 Neighboring gene STARR-seq mESC enhancer starr_05251 Neighboring gene STARR-seq mESC enhancer starr_05252 Neighboring gene predicted gene, 39890 Neighboring gene STARR-seq mESC enhancer starr_05255 Neighboring gene STARR-seq mESC enhancer starr_05256 Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene STARR-seq mESC enhancer starr_05257 Neighboring gene STARR-seq mESC enhancer starr_05258 Neighboring gene predicted gene, 57687 Neighboring gene solute carrier family 1 (glial high affinity glutamate transporter), member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. Al-Greene NT, et al. PLoS One, 2013. PMID 23922772, Free PMC Article
  2. The rodent Four-jointed ortholog Fjx1 regulates dendrite extension. Probst B, et al. Dev Biol, 2007 Dec 1. PMID 18028897
  3. [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway]. Zhang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2023 Jun 20. PMID 37439170, Free PMC Article
  4. Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury. Formica C, et al. J Pathol, 2019 Sep. PMID 31038742, Free PMC Article
  5. Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain. Ashery-Padan R, et al. Mech Dev, 1999 Feb. PMID 10072791

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
    Title: [FJX1 overexpression is associated with poor prognosis and promotes gastric cancer proliferation via the PI3K/AKT signaling pathway].
  2. Fjx1 disruption protects the cystic kidneys against kidney failure by reducing inflammation and fibrosis.
    Title: Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.
  3. These results identify Fjx1 as a new inhibitory factor that regulates dendrite extension.
    Title: The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.
  4. fjx1 is expressed in the peripheral nervous system, epithelial cells of multiple organs, and during limb development
    Title: Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.
  5. data are compatible with conservation and sub-functionalization of dachsous 1, Fj, and Fat signaling in higher vertebrates
    Title: Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina layer formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
four-jointed box protein 1
Names
four-jointed protein homolog
four-jointed protein x1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010218.2 → NP_034348.2  four-jointed box protein 1 precursor

    See identical proteins and their annotated locations for NP_034348.2

    Status: PROVISIONAL

    Source sequence(s)
    BC051990
    Consensus CDS
    CCDS16467.1
    UniProtKB/Swiss-Prot
    Q8BQB4, Q9Z1M1
    Related
    ENSMUSP00000097270.4, ENSMUST00000099678.5
    Conserved Domains (1) summary
    cd10468
    Location:146 → 430
    Four-jointed-like_C; C-terminal kinase domain of Drosophila Four-jointed (Fj), mouse Fjx1, and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    102279711..102282137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQB4.1 GenPept UniProtKB/Swiss-Prot:Q8BQB4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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