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Smc2 structural maintenance of chromosomes 2 [ Mus musculus (house mouse) ]

Gene ID: 14211, updated on 5-Mar-2024

Summary

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Official Symbol
Smc2provided by MGI
Official Full Name
structural maintenance of chromosomes 2provided by MGI
Primary source
MGI:MGI:106067
See related
Ensembl:ENSMUSG00000028312 AllianceGenome:MGI:106067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAPE; CAP-E; Fin16; SMC-2; Smc2l1; 5730502P04Rik
Summary
The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Biased expression in liver E14 (RPKM 13.6), CNS E11.5 (RPKM 12.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Smc2 in Genome Data Viewer
Location:
4 B2; 4 28.31 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (52438966..52488365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (52439221..52488365)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA-directed), delta 3, accessory subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_10208 Neighboring gene STARR-seq mESC enhancer starr_10209 Neighboring gene STARR-positive B cell enhancer ABC_E3492 Neighboring gene structural maintenance of chromosomes 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_10210 Neighboring gene Tmc4 retrotransposed pseudogene Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene Neighboring gene STARR-seq mESC enhancer starr_10212 Neighboring gene topoisomerase I binding, arginine/serine-rich like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. Fazzio TG, et al. J Cell Biol, 2010 Feb 22. PMID 20176923, Free PMC Article
  2. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Griese JJ, et al. Nucleic Acids Res, 2010 Jun. PMID 20139420, Free PMC Article
  3. Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. Nishide K, et al. PLoS Genet, 2014 Dec. PMID 25474630, Free PMC Article
  4. YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus. Pan X, et al. EMBO J, 2013 Apr 17. PMID 23531880, Free PMC Article
  5. Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. Kawakami Y, et al. Neurosci Res, 2009 Mar. PMID 19114063

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice.
    Title: Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kinetochore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single strand break repair TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of condensin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
structural maintenance of chromosomes protein 2
Names
FGF-inducible protein 16
SMC protein 2
SMC2 structural maintenance of chromosomes 2-like 1
XCAP-E homolog
chromosome-associated protein E
fibroblast growth factor inducible 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301412.1 → NP_001288341.1  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_001288341.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK145341, BC094380, CJ049961
    Consensus CDS
    CCDS18180.1
    UniProtKB/Swiss-Prot
    Q52KE9, Q61076, Q8CG48, Q9CS17, Q9CSD8
    UniProtKB/TrEMBL
    Q3ULS2
    Related
    ENSMUSP00000099979.4, ENSMUST00000102915.10
    Conserved Domains (1) summary
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_008017.4 → NP_032043.3  structural maintenance of chromosomes protein 2

    See identical proteins and their annotated locations for NP_032043.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK145341, BC094380, CJ049961
    Consensus CDS
    CCDS18180.1
    UniProtKB/Swiss-Prot
    Q52KE9, Q61076, Q8CG48, Q9CS17, Q9CSD8
    UniProtKB/TrEMBL
    Q3ULS2
    Related
    ENSMUSP00000113940.2, ENSMUST00000117280.8
    Conserved Domains (1) summary
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    52438966..52488365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163679.1 → XP_036019572.1  structural maintenance of chromosomes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q52KE9, Q61076, Q8CG48, Q9CS17, Q9CSD8
    UniProtKB/TrEMBL
    Q3ULS2
    Conserved Domains (1) summary
    COG1196
    Location:1 → 1168
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CG48.2 GenPept UniProtKB/Swiss-Prot:Q8CG48

Gene LinkOut

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