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Fhl4 four and a half LIM domains 4 [ Mus musculus (house mouse) ]

Gene ID: 14202, updated on 8-Feb-2024

Summary

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Official Symbol
Fhl4provided by MGI
Official Full Name
four and a half LIM domains 4provided by MGI
Primary source
MGI:MGI:1338765
See related
Ensembl:ENSMUSG00000050035 AllianceGenome:MGI:1338765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of mitotic cell cycle phase transition; regulation of membrane depolarization; and regulation of potassium ion transport. Predicted to be located in cytosol; nucleus; and plasma membrane. Is expressed in bladder; testis; and ureter. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 654.1) See more
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Genomic context

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See Fhl4 in Genome Data Viewer
Location:
10 C1; 10 41.63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84932883..84938359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (85097019..85102495, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIC8 guanine nucleotide exchange factor B Neighboring gene predicted gene, 34633 Neighboring gene STARR-seq mESC enhancer starr_27436 Neighboring gene STARR-seq mESC enhancer starr_27437 Neighboring gene STARR-seq mESC enhancer starr_27438 Neighboring gene predicted gene, 51826 Neighboring gene transmembrane protein 263 Neighboring gene STARR-positive B cell enhancer ABC_E722 Neighboring gene mitochondrial transcription termination factor 2 Neighboring gene cryptochrome circadian regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The fourth member of the FHL family of LIM proteins is expressed exclusively in the testis. Morgan MJ, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049694
  2. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Morgan MJ, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049693
  3. A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM. Fimia GM, et al. Mol Cell Biol, 2000 Nov. PMID 11046156, Free PMC Article
  4. The complexity of antisense transcription revealed by the study of developing male germ cells. Chan WY, et al. Genomics, 2006 Jun. PMID 16458478
  5. Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Chung YC, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20932939

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
four and a half LIM domains 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010214.4 → NP_034344.2  four and a half LIM domains 4

    See identical proteins and their annotated locations for NP_034344.2

    Status: VALIDATED

    Source sequence(s)
    AC122238, AK029585
    Consensus CDS
    CCDS24086.1
    UniProtKB/TrEMBL
    Q6P8P1, Q8CDC8, Q9DAH0
    Related
    ENSMUSP00000050054.7, ENSMUST00000059383.8
    Conserved Domains (4) summary
    cd09348
    Location:216 → 279
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:100 → 157
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:161 → 213
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:39 → 92
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    84932883..84938359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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