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Fhl3 four and a half LIM domains 3 [ Mus musculus (house mouse) ]

Gene ID: 14201, updated on 3-Apr-2024

Summary

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Official Symbol
Fhl3provided by MGI
Official Full Name
four and a half LIM domains 3provided by MGI
Primary source
MGI:MGI:1341092
See related
Ensembl:ENSMUSG00000032643 AllianceGenome:MGI:1341092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SLIM2
Summary
Enables actin binding activity. Acts upstream of or within actin cytoskeleton organization. Located in Z disc; nucleus; and stress fiber. Is expressed in several structures, including genitourinary system; heart; lung; skeletal muscle; and thymus. Orthologous to human FHL3 (four and a half LIM domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 16.6), stomach adult (RPKM 11.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.88 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124589750..124602404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124695964..124708611)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38545 Neighboring gene UTP11 small subunit processome component Neighboring gene STARR-positive B cell enhancer ABC_E6213 Neighboring gene STARR-seq mESC enhancer starr_11340 Neighboring gene STARR-positive B cell enhancer ABC_E6214 Neighboring gene splicing factor 3a, subunit 3 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene microRNA 697

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of the human LIM protein ACT gene and its expression in tumor cell lines. Morgan MJ, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873680
  2. FHL3 binds MyoD and negatively regulates myotube formation. Cottle DL, et al. J Cell Sci, 2007 Apr 15. PMID 17389685
  3. FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB. Zhang Y, et al. Cell Signal, 2016 Jan. PMID 26499038
  4. Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system. Chu PH, et al. Mech Dev, 2000 Jul. PMID 10906474
  5. FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly. Coghill ID, et al. J Biol Chem, 2003 Jun 27. PMID 12704194

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Four and a half LIM domain protein 3 could interact with MyoD, cyclic AMP-responsive elements and phosphorylated cAMP response element binding protein in vivo
    Title: FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB.
  2. These studies demonstrate that Sox15, Fhl3 and Foxk1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration.
    Title: Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells.
  3. FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells
    Title: The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.
  4. Actin was identified as a FHL3 binding partner; FHL3 is a significant regulator of actin cytoskeletal dynamics in skeletal myoblasts.
    Title: FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
four and a half LIM domains protein 3
Names
skeletal muscle LIM-protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418979.1 → NP_001405908.1  four and a half LIM domains protein 3

    Status: VALIDATED

    Source sequence(s)
    AL606907
    UniProtKB/Swiss-Prot
    A6H6N4, Q9JLP5, Q9R059, Q9WUH3

  2. NM_001418980.1 → NP_001405909.1  four and a half LIM domains protein 3

    Status: VALIDATED

    Source sequence(s)
    AL606907
    UniProtKB/Swiss-Prot
    A6H6N4, Q9JLP5, Q9R059, Q9WUH3

  3. NM_001418981.1 → NP_001405910.1  four and a half LIM domains protein 3

    Status: VALIDATED

    Source sequence(s)
    AL606907
    UniProtKB/Swiss-Prot
    A6H6N4, Q9JLP5, Q9R059, Q9WUH3

  4. NM_001418982.1 → NP_001405911.1  four and a half LIM domains protein 3

    Status: VALIDATED

    Source sequence(s)
    AL606907
    UniProtKB/Swiss-Prot
    A6H6N4, Q9JLP5, Q9R059, Q9WUH3

  5. NM_010213.4 → NP_034343.2  four and a half LIM domains protein 3

    See identical proteins and their annotated locations for NP_034343.2

    Status: VALIDATED

    Source sequence(s)
    AL606907
    Consensus CDS
    CCDS38874.1
    UniProtKB/Swiss-Prot
    A6H6N4, Q9JLP5, Q9R059, Q9WUH3
    UniProtKB/TrEMBL
    F2Z455
    Related
    ENSMUSP00000040150.6, ENSMUST00000038684.6
    Conserved Domains (4) summary
    cd09346
    Location:162 → 213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:36 → 94
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98 → 155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:221 → 285
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RNA

  1. NR_184996.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606907

  2. NR_184997.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606907

  3. NR_184998.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606907

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124589750..124602404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163678.1 → XP_036019571.1  four and a half LIM domains protein 3 isoform X2

    UniProtKB/TrEMBL
    F2Z455
    Conserved Domains (4) summary
    cd09346
    Location:170 → 221
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:44 → 102
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:106 → 163
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:229 → 293
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R059.2 GenPept UniProtKB/Swiss-Prot:Q9R059

Gene LinkOut

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