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Fgf14 fibroblast growth factor 14 [ Mus musculus (house mouse) ]

Gene ID: 14169, updated on 16-Apr-2024

Summary

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Official Symbol
Fgf14provided by MGI
Official Full Name
fibroblast growth factor 14provided by MGI
Primary source
MGI:MGI:109189
See related
Ensembl:ENSMUSG00000025551 AllianceGenome:MGI:109189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fhf4; FHF-4; Fgf1b; FGF-14; mFHF-4(1B); Tg(tetO-MAPT*P301L)4510Kha
Summary
Predicted to enable growth factor activity; heparin binding activity; and sodium channel regulator activity. Acts upstream of or within several processes, including adult locomotory behavior; neuromuscular process; and positive regulation of ion transport. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; respiratory system; and sensory organ. Used to study spinocerebellar ataxia type 27. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 27. Orthologous to human FGF14 (fibroblast growth factor 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 4.3), cortex adult (RPKM 2.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 E5; 14 66.18 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (124211257..124915098, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (123974441..124677686, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37795 Neighboring gene STARR-seq mESC enhancer starr_37796 Neighboring gene integrin, beta-like 1 Neighboring gene basic transcription factor 3, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_37797 Neighboring gene RIKEN cDNA 1700024B18 gene Neighboring gene predicted gene, 25272 Neighboring gene STARR-seq mESC enhancer starr_37799 Neighboring gene STARR-seq mESC enhancer starr_37800 Neighboring gene predicted gene 15422 Neighboring gene STARR-seq mESC enhancer starr_37801 Neighboring gene predicted gene, 53849 Neighboring gene STARR-seq mESC enhancer starr_37802 Neighboring gene STARR-seq mESC enhancer starr_37804 Neighboring gene STARR-seq mESC enhancer starr_37805 Neighboring gene olfactory receptor family 6 subfamily C member 220, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_37806 Neighboring gene STARR-seq mESC enhancer starr_37807

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered low-frequency brain rhythms precede changes in gamma power during tauopathy. Rodrigues FR, et al. iScience, 2022 Oct 21. PMID 36274955, Free PMC Article
  2. Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice. de Oliveira P, et al. J Neurosci, 2022 Apr 20. PMID 35273086, Free PMC Article
  3. PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain. Schaler AW, et al. Sci Transl Med, 2021 May 26. PMID 34039738, Free PMC Article
  4. Differential accumulation of tau pathology between reciprocal F1 hybrids of rTg4510 mice. Yanagisawa D, et al. Sci Rep, 2021 May 5. PMID 33953293, Free PMC Article
  5. Age-dependent impairment of memory and neurofibrillary tangle formation and clearance in a mouse model of tauopathy. Kubota T, et al. Brain Res, 2021 Aug 15. PMID 33894222

See all (187) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria.
    Title: TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria.
  2. Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
    Title: Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
  3. JAK2 regulates Nav1.6 channel function via FGF14(Y158) phosphorylation.
    Title: JAK2 regulates Nav1.6 channel function via FGF14(Y158) phosphorylation.
  4. Effects of FGF14 and NaVbeta4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons.
    Title: Effects of FGF14 and Na(V)β4 deletion on transient and resurgent Na current in cerebellar Purkinje neurons.
  5. These new insights into the biology of FGF14 in neurogenesis shed light into the signaling pathways associated with disrupted functions in complex brain diseases.
    Title: Fibroblast Growth Factor 14 Modulates the Neurogenesis of Granule Neurons in the Adult Dentate Gyrus.
  6. These results indicate that Fgf14(-/-) mice recapitulate salient molecular, cellular, functional and behavioral features associated with human cognitive impairment, and FGF14 loss of function might be associated with the biology of complex brain disorders such as schizophrenia.
    Title: Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia.
  7. TWEAK/Fn14 pathway instrumental in the pathogenesis of spontaneous lupus nephritis
    Title: Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis.
  8. The results of this study demonstrated that iFGF14 is required for spontaneous and evoked action potential firing in adult Purkinje neurons, thereby controlling the output of these cells and the regulation of motor coordination and balance.
    Title: Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance.
  9. These data suggest that the FGF14b N-terminus is a potent regulator of resurgent NaV current in cerebellar Purkinje neurons.
    Title: FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons.
  10. FGF14 is localized in a decreasing proximal to distal gradient along the axon initial segment of Purkinje neurons.
    Title: FGF14 localization and organization of the axon initial segment.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC129318, MGC129319

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor 14
Names
fibroblast growth factor 1b
fibroblast growth factor homologous factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010201.5 → NP_034331.2  fibroblast growth factor 14 isoform a

    See identical proteins and their annotated locations for NP_034331.2

    Status: VALIDATED

    Source sequence(s)
    AC154195, AC161001
    Consensus CDS
    CCDS27356.1
    UniProtKB/Swiss-Prot
    P70379, Q3KNZ6, Q8BST0, Q9JHL9
    UniProtKB/TrEMBL
    A0A0R4J063
    Related
    ENSMUSP00000026631.6, ENSMUST00000026631.6
    Conserved Domains (1) summary
    pfam00167
    Location:72 → 197
    FGF; Fibroblast growth factor

  2. NM_207667.4 → NP_997550.1  fibroblast growth factor 14 isoform b

    See identical proteins and their annotated locations for NP_997550.1

    Status: VALIDATED

    Source sequence(s)
    AC154195, AC161001, AC164978
    Consensus CDS
    CCDS27355.1
    UniProtKB/TrEMBL
    O89096
    Related
    ENSMUSP00000093185.4, ENSMUST00000095529.10
    Conserved Domains (1) summary
    pfam00167
    Location:77 → 202
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    124211257..124915098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315845.2 → XP_017171334.1  fibroblast growth factor 14 isoform X1

    Conserved Domains (1) summary
    smart00442
    Location:22 → 152
    FGF; Acidic and basic fibroblast growth factor family

  2. XM_011244952.4 → XP_011243254.1  fibroblast growth factor 14 isoform X2

    See identical proteins and their annotated locations for XP_011243254.1

    UniProtKB/Swiss-Prot
    P70379
    Conserved Domains (1) summary
    pfam00167
    Location:1 → 113
    FGF; Fibroblast growth factor

  3. XM_006518549.5 → XP_006518612.1  fibroblast growth factor 14 isoform X3

    Conserved Domains (1) summary
    cl00060
    Location:74 → 141
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70379.1 GenPept UniProtKB/Swiss-Prot:P70379

Gene LinkOut

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