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Fgf13 fibroblast growth factor 13 [ Mus musculus (house mouse) ]

Gene ID: 14168, updated on 21-Apr-2024

Summary

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Official Symbol
Fgf13provided by MGI
Official Full Name
fibroblast growth factor 13provided by MGI
Primary source
MGI:MGI:109178
See related
Ensembl:ENSMUSG00000031137 AllianceGenome:MGI:109178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fhf2; Fgf1c
Summary
Enables sodium channel regulator activity; transmembrane transporter binding activity; and tubulin binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of cardiac muscle cell action potential involved in regulation of contraction. Located in several cellular components, including growth cone; intercalated disc; and lateral plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Used to study intellectual disability. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 22.7), frontal lobe adult (RPKM 16.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A6; X 33.31 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (58107499..58630932, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (59062139..59585572, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene MAGE family member A13 Neighboring gene microRNA 504 Neighboring gene predicted gene, 26487 Neighboring gene histidyl-tRNA synthetase 2, mitochondrial (putative) pseudogene Neighboring gene predicted gene, 39518 Neighboring gene STARR-seq mESC enhancer starr_47232 Neighboring gene STARR-seq mESC enhancer starr_47233 Neighboring gene STARR-seq mESC enhancer starr_47234 Neighboring gene STARR-seq mESC enhancer starr_47235 Neighboring gene predicted gene, 36631 Neighboring gene STARR-seq mESC enhancer starr_47236 Neighboring gene synaptophysin-like protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy. Shen KF, et al. Cereb Cortex, 2022 Nov 21. PMID 35195262
  2. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Yu Y, et al. Front Cell Neurosci, 2021. PMID 34220452, Free PMC Article
  3. Fibroblast growth factor 13 stabilizes microtubules to promote Na(+) channel function in nociceptive DRG neurons and modulates inflammatory pain. Wang Q, et al. J Adv Res, 2021 Jul. PMID 34194835, Free PMC Article
  4. FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with Na(V)1.7. Dong F, et al. J Neurosci, 2020 Dec 9. PMID 33172979, Free PMC Article
  5. Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart. Park DS, et al. Circ Res, 2020 Dec 4. PMID 32962518, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhanced sodium channel inactivation by temperature and FHF2 deficiency blocks heat nociception.
    Title: Enhanced sodium channel inactivation by temperature and FHF2 deficiency blocks heat nociception.
  2. Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy.
    Title: Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy.
  3. 5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
    Title: 5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
  4. Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.
    Title: Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.
  5. FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with NaV1.7.
    Title: FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with Na(V)1.7.
  6. E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.
    Title: E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.
  7. Heterozygous Fgf13 knockouts fed normal chow.
    Title: Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
  8. High FGF13 expression is associated with glioma cell invasion.
    Title: Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.
  9. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors
    Title: Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors.
  10. FHF2 has an essential role in dictating myocardial excitability and conduction that safeguards against temperature-sensitive conduction failure
    Title: Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in establishment of neuroblast polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of neuroblast polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippocampus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inhibitory synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor 13
Names
fibroblast growth factor 1c
fibroblast growth factor homologous factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290414.1 → NP_001277343.1  fibroblast growth factor 13 isoform 2

    See identical proteins and their annotated locations for NP_001277343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1. Variants 2 and 5-8 all encode the same isoform (2).
    Source sequence(s)
    AL669891, AL670091, AL672247, AL713968
    Conserved Domains (1) summary
    smart00442
    Location:77 → 207
    FGF; Acidic and basic fibroblast growth factor family

  2. NM_001290415.1 → NP_001277344.1  fibroblast growth factor 13 isoform 3

    See identical proteins and their annotated locations for NP_001277344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK141848, BC018238, CD776909, CJ064772
    Consensus CDS
    CCDS72383.1
    UniProtKB/TrEMBL
    B1AU20
    Related
    ENSMUSP00000113206.2, ENSMUST00000119306.2
    Conserved Domains (1) summary
    smart00442
    Location:14 → 144
    FGF; Acidic and basic fibroblast growth factor family

  3. NM_001356335.1 → NP_001343264.1  fibroblast growth factor 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL713968
    UniProtKB/TrEMBL
    B1AU20
    Conserved Domains (1) summary
    smart00442
    Location:21 → 151
    FGF; Acidic and basic fibroblast growth factor family

  4. NM_001411971.1 → NP_001398900.1  fibroblast growth factor 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL672247, AL713968

  5. NM_001411972.1 → NP_001398901.1  fibroblast growth factor 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL672247, AL713968

  6. NM_001411973.1 → NP_001398902.1  fibroblast growth factor 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL672247, AL713968

  7. NM_001425598.1 → NP_001412527.1  fibroblast growth factor 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL672247, AL713968

  8. NM_001425599.1 → NP_001412528.1  fibroblast growth factor 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL713968

  9. NM_001425600.1 → NP_001412529.1  fibroblast growth factor 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL713968

  10. NM_001425601.1 → NP_001412530.1  fibroblast growth factor 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL713968

  11. NM_010200.3 → NP_034330.2  fibroblast growth factor 13 isoform 1

    See identical proteins and their annotated locations for NP_034330.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC018238, CD776909
    Consensus CDS
    CCDS30157.1
    UniProtKB/Swiss-Prot
    B1AU21, O35338, P70377, Q3UR31, Q8VCY9, Q9JLA5
    UniProtKB/TrEMBL
    A0A7U3JW69
    Related
    ENSMUSP00000033473.6, ENSMUST00000033473.12
    Conserved Domains (1) summary
    smart00442
    Location:67 → 197
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    58107499..58630932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527799.3 → XP_006527862.1  fibroblast growth factor 13 isoform X3

    UniProtKB/TrEMBL
    B1AU20
    Conserved Domains (1) summary
    smart00442
    Location:11 → 141
    FGF; Acidic and basic fibroblast growth factor family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70377.2 GenPept UniProtKB/Swiss-Prot:P70377

Gene LinkOut

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